赵宪鹤 博士、讲师、硕士生导师 邮箱： zhaoxh@lzu.edu.cn

·教育背景、工作经历

2017-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室，讲师

2010-2017           兰州大学 (导师: 樊春安)，理学博士

2006-2010           聊城大学，理学学士

·研究兴趣

生物活性显著、化学结构新颖的天然产物的全合成研究

·代表成果

1. Palladium-Catalyzed Asymmetric (4 + 2) Annulation of gamma-Methylidene-delta-valerolactones with Alkenes: Enantioselective Synthesis of Functionalized Chiral Cyclohexyl Spirooxindoles. Zhi-Long Jia, Xian-Tao An, Yu-Hua Deng, Lin-Han Pang, Chun-Fang Liu, Le-Le Meng, Jia-Kun Xue, Xian-He Zhao*, and Chun-An Fan*, Org. Lett. 2021, 23, 745-750.

2. Tandem (2 + 2) Annulation/Retro-4 pi Electrocyclization/Imino-Nazarov Cyclization Reaction of p-Quinone Methides with Ynamides: Expeditious Construction of Functionalized Aminoindenes. Ke-Yin Yu, Yu-Hua Deng, Xiao-Min Ge, Xian-Tao An, Peng-Fei Shu, Ye-Xing Cao, Xian-He Zhao*, and Chun-An Fan*, Org. Lett. 2021, 23, 5885-5890.

3. Asymmetric Catalytic [4+5] Annulation of Ortho-Quinone Methides with Vinylethylene Carbonates and Its Extension to Stereoselective Tandem Rearrangement. Xiantao An, Jiyuan Du, Zhilong Jia, Qing Zhang, Keyin Yu, Yizhou Zhang, Xianhe Zhao, Ran Fang, and Chunan Fan*. Chem.-Eur. J.  2020, 26, 3803-3809.

4. Palladium-Catalyzed Asymmetric (2+3) Annulation of p-Quinone Methides with Trimethylenemethanes: Enantioselective Synthesis of Functionalized Chiral Spirocyclopentyl p-Dienones. Zhilong Jia, Xiantao An,Yuhua Deng,Huibin Wang, Kangji Gan, Jing Zhang, Xianhe Zhao*, and Chunan Fan*.  Org. Lett. 2020, 22, 4171-4175.

5. Total Synthesis of (±)-Lycojaponicumin D and Lycodoline-Type Lycopodium Alkaloids. Xianhe Zhao, Qing Zhang, Jiyuan Du, Xinyun Lu, Yexing Cao, Yuhua Deng, and Chun-An Fan*. J. Am. Chem. Soc. 2017, 139, 7095-7103.

6. Asymmetric Total Synthesis of Apocynaceae Hydrocarbazole Alkaloids (+)-Deethylibophyllidine and (+)-Limaspermidine. Du Jiyuan, Zeng Chao, Han Xiaojie, Qu Hu, Zhao Xianhe, An Xiantao, and Fan Chunan*. J. Am. Chem. Soc. 2015, 137, 4267-4273.

7. Bioinspired Total Synthesis of Montanine-Type Amaryllidaceae Alkaloids. Bao Xu, Cao Yexing, Chu Wendao, Qu Hu, Du Jiyuan, Zhao Xianhe, Ma Xiaoyan, Wang Chengtao, and Fan Chunan*.  Angew. Chem. Int. Ed. 2013, 52, 14167-14172.

8. Asymmetric Catalytic 1,6-Conjugate Addition/Aromatization of para-Quinone Methides: Enantioselective Introduction of Functionalized Diarylmethine Stereogenic Centers. Chu Wendao, Zhang Lefen, Bao Xu, Zhao Xianhe, Zeng Chao, Du Jiyua, Zhang Guobiao, Wang Fangxin, Ma Xiaoyan, and Fan Chunan*.  Angew. Chem. Int. Ed. 2013, 52, 9229-9233.