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谢新刚

谢新刚
谢新刚
博士、副教授、硕士生导师
电话:
+86-13919353465
邮箱:
xiexg@lzu.edu.cn

•教育背景、工作经历

2012-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授

2010-2012           兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师

2006-2010           香港中文大学 (导师: 黄乃正),博士后

2001-2006           兰州大学,理学博士

1997-2001           兰州大学,理学学士

•荣誉奖励

2018               Thieme Chemistry Journal Award

2015               甘肃省自然科学一等奖(排名第二)

2007               甘肃省自然科学二等奖(排名第三)

2007               Tetrahedron Letters Most cited paper 2004-2007 Award

•研究兴趣

主要从事绿色、高效的合成方法学及具有良好生理活性的天然产物全合成研究

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•代表成果 

1. Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids. Zhimin Xing, Bowen Fang, Shangwen Luo, Xingang Xie*, and Xiaolei Wang*, Org. Lett. 2022, 24, 4034.

2. Rapid Construction of Indole-fused 8-10 Membered Lactones via a Tandem Reaction. Zhen Li†, Shiqiang Ma†, Fuhai Liu, Ruize Ma, Jipeng Zhao, Xingang Xie*, and Xuegong She, Org. Biomol. Chem. 2022, 20, 6314.

3. Concise Total Syntheses of Bioactive Alkaloids Enabled by Development or Application of Cascade Reactions: a Personnel Adventure. Xingang Xie, Xuegong She*, Chinese J. Chem. 202139, 795-801.

4. Thiourea Catalyzed 1,6-Conjugate Addition of Indoles to Para-Quinone Methides. Guangmiao Wu, Tao Li, Fuhai Liu, Yulong Zhao, Shiqiang Ma, Shouchu Tang, Xingang Xie*, Xuegong She, Tetrahedron Lett2021, 81, 153315.

5. Enantioselective αFunctionalization of 1,3-Dithianes by Iridium-Catalyzed Allylic Substitution. Panpan Wang, Qian Jiang, Ruibo Zhao, Xingang Xie*. Shouchu Tang*, and Xiaolei Wang*. J. Org. Chem. 2020, 85,12456-12467.

6. Visible Light Photoredox Catalyzed Deprotection of 1,3-Oxathiolanes. Mingyang Yang, Zhimin Xing, Bowen Fang, Xingang Xie,* and Xuegong She. Org. Biomol. Chem. 2020, 18, 288-291.

7. Total syntheses of (-)-15-oxopuupehenol and (+)-puupehenone and formal syntheses of (-)-puupehenol and (+)-puupehedione, Huayue Song, Lin Liu, Mingyang Yang, Guangmiao Wu, Peng Chen, Xingang Xie * and Xuegong She, Org. Chem. Front. 20201, 35-42.

8. Synthetic studies towards daphniyunnine B: Construction of AC bicyclic skeleton with two vicinal all carbon quaternary stereocenters, Haiyu Sun, Guangmiao Wu and Xingang Xie*. Chinese Chem. Lett. 201930, 1538-1540.

9. Concise formal synthesis of (+)-pyripyropene A. Tao Li, Guangmiao Wu, Shangbiao Feng, Xiaojun Hu, Weiwei Zhang, Shouchu Tang, Xingang Xie*, Xuegong She, Tetrahedron 201975, 3939-3942.

10. Total synthesis of (-)-8-epi-chromazonarol enabled by a unique N2H4•H2O promoted intramolecular oxa-Michael cyclization reaction, Lin Liu, Huayue Song, Peng Chen, Ziyun Yuan, Shangbiao Feng, Weiwei Zhang, Bowen Fang, Xingang Xie*, Xuegong She. Org. Chem. Front. 20185, 3013-3017.

11. Visible-light promoted dithioacetalization of aldehydes with thiols under aerobic and photocatalyst-free conditions, Zhimin Xing, Mingyang Yang, Haiyu Sun, Zemin Wang, Peng Chen, Lin Liu, Xiaolei Wang, Wang*,  Xingang Xie*, Xuegong She. Green Chem. 201820, 5117-5122.

12. A rapid construction of the ABC tricyclic skeleton of malabanone A, Tao Li,  Guangmiao Wu, Shangbiao Feng, Zemin Wang, Xingang Xie*, Xuegong She.  Org. Biomol. Chem. 201816, 8491-8494.

13. Rapid construction of complex tetracyclic frameworks via a gold(I)-catalyzed tandem 1,2-acyloxy migration/[3 + 2] cycloaddition/Friedel–Crafts type cyclization reaction of linear enynyl esters. Haiyu Sun, Shiyan Xu, Zhimin Xing, Lin Liu, Shangbiao Feng, Bowen Fang, Xingang Xie*, and  Xuegong She. Org. Chem. Front20174, 2109-2113.

14. Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A. Hao Zhang, Shiqiang Ma, Zhimin Xing, Lin Liu, Bowen Fang, Xingang Xie*, and Xuegong She*. Org. Chem. Front20174, 2211–2215.

15. Visible-Light-Promoted Dual C−C Bond Formations of Alkynoates via a Domino Radical  Addition/ Cyclization Reaction: A Synthesis of Coumarins. Shangbiao Feng, Xingang Xie*, Weiwei Zhang, Lin Liu, Zhuliang Zhong, Dengyu Xu, and Xuegong She.Org. Lett. 201618, 3846−3849.

16. An Efficient Synthesis of Benzazocines by Gold(I)-Catalyzed Tandem 1,2-Acyloxy Shift/[3+2] Cycloaddition of Terminal 1,9-Enynyl Esters. Shangbiao Feng, Zhengshen Wang, Weiwei Zhang, Xingang Xie*, and Xuegong She. Chem.-Asian J. 201611, 2167–2172.

17. Concise Total Synthesis of Isospongian Diterpenoid (±)-Polyrhaphin D. Zemin Wang, Zhimin Xing, Lin Liu, Hao Zhang, Zhuliang Zhong, Xingang Xie*, and Xuegong She.  ChemistrySelect 20161, 2225–2227.

18. Gold(I)-Catalyzed Tandem Reaction of γ-Amino-Substituted Propargylic Esters to Pyrrolines and its Application in the Formal Synthesis of (±)-Aphanorphine. Zhengshen Wang, Huaiji Zheng, Juan Yang, Xingang Xie*, and Xuegong She*. Adv. Synth. Catal. 2015357, 2082–2088.

19. Scalable, efficient total synthesis of (+)-mupirocin H. Changgui Zhao, Ziyun Yuan, Yuanyuan Zhang, Bin Ma, Huilin Li, Shouchu Tang, Xingang Xie* and  Xuegong She*. Org. Chem. Front. 20141, 105-108.

20. Enantioselective Total Synthesis of ()-Walsucochin B. Shiyan Xu, Jixiang Gu, Huilin Li, Donghui Ma, Xingang Xie*, and Xuegong She. Org. Lett201416, 1996-1999.

21. Concise Formal Syntheses of the Amaryllidaceae Alkaloids (±)-Tazettine and (±)-6a-Epi- pretazettine: Construction of the Core Skeleton via Tandem Intramolecular Oxidative Friedel– Crafts / Aza-Michael Reaction. Donghui Ma, Changgui Zhao, Huilin Li, Jing Qi, Ling Zhang, Shiyan Xu, Xingang Xie*, and  Xuegong She*. Chem.-Asian. J. 20138, 364-368.

22. Concise Enantioselective Synthesis of Cephalosporolide B, (4R)-4-OMe-Cephalo- sporolide C, and (4S)-4-OMe Cephalosporolide C. Bin Ma, Zhuliang Zhong, Haitao Hu, Huilin Li, Changgui Zhao, Xingang Xie*, and Xuegong She*. Chem.-Asian. J20138, 1391-1394.

23. Tandem Oxidative Dearomatization/Intramolecular Diels-Alder Reaction for Construction of the Tricyclic Core of Palhinine A. Changgui Zhao, Huaiji Zheng, Peng Jing, Bowen Fang, Xingang Xie*, and Xuegong She*. Org. Lett201214, 2293-2295.

24. Total Synthesis of (±)-Kopsihainanine A. Masaya Mizutani, Shigeo Yasuda, and  Chisato Mukai*.  Chem.-Eur. J201218, 6729-6732.

25. Rapid Construction of the [6-6-6-5] Tetracyclic Skeleton of the Daphniphyllum Alkaloid Daphenylline. Huilin Li, Jiyue Zheng, Shiyan Xu, Donghui Ma, Changgui Zhao, Bowen Fang, Xingang Xie*and Xuegong She*. Chem.-Asian. J. 20127, 2519-2522.

 


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