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李辉林

李辉林
李辉林
博士、教授、硕士生导师
电话:
+86-17361653313
邮箱:
lihuilin@lzu.edu.cn

·教育背景、工作经历

2023.06-至今                  兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2018.06-2023.06            兰州大学化学化工学院、功能有机分子化学国家重点实验室,青年研究员

2016.11-2018.06            新加坡国立大学化学系 (导师:卢一新教授),博士后

2015.06-2016.10            香港科技大学化学系 (导师:孙建伟教授),博士后

2010.09-2015.06            兰州大学 (导师: 厍学功),理学博士

2006.09-2010.06            兰州大学,理学学士

·研究兴趣

天然产物全合成,天然产物结构导向的方法学研究,不对称催化等

·代表成果

1. Total Synthesis of the Euphorbia Diterpenoid Pepluacetal. Meng Liu, Chuanhua Wu, Xingang Xie,Huilin Li*, and Xuegong She*, Angew. Chem. Int. Ed.2024, e202400943.

2. Rearrangement of the Tetra- and Tricyclic Skeletons of Pepluanol B to Access the Core Structures of Tigliane- and Myrsinane-Type Euphorbia Diterpenes. Chuanhua Wu, Jing Zhang, Meng Liu, Xingang Xie, Huilin Li*, and Xuegong She*, Org. Lett.2023, 25, 7995.

3. Catalyst-Free 1,2-Dibromination of Alkenes Using 1,3-Dibromo-5,5-dimethylhydantoin (DBDMH) as a Bromine Source. Lei Wang, Lele Zhai, Jinyan Chen, Yulin Gong, Peng Wang, Huilin Li*, and Xuegong She, J. Org. Chem. 2022, 87, 3177.

4. Solvent-free, B(C6F5)3-Catalyzed S-H Insertion of Thiophenols and Thiols with α-Diazoesters. Peng Wang, Yulin Gong, Xiaoyu Wang, Yangqing Ren, Lei Wang, Lele Zhai, Huilin Li* and Xuegong She, Chem - Asian J. 2022, 17, e202200465.

5. Organoborane-Catalyzed Selective 1,2-Reduction of Alkynones with Hydride Transfer: Synthesis of Benzyl Alkynes. Lele Zhai, Zhigang Yang, Qinghong Man, Mingyu Yang, Yangqing Ren, Lei Wang, Huilin Li*, and Xuegong She, Tetrahedron Lett. 2022, 91, 153645.

6. The Total Synthesis of Diquinane-Containing Natural Products. Huilin Li*, Jing Zhang, and Xuegong She*, Chem-Eur. J. 2021, 27, 4839-4858.

6. Recent Advances in Total Synthesis of Diquinane-Containing Natural Products, Huilin Li*, Jing Zhang, Xuegong She*. Chem.-Eur. J2021, 27, 1-21.

8. Total Synthesis of (-)-Pepluanol B: Conformational Control of the Eight-Membered Ring System, Jing Zhang, Meng Liu, Chuanhua Wu, Gaoyuan Zhao, Peiqi Chen, Lin Zhou, Xingang Xie, Ran Fang, Huilin Li*, and Xuegong She*. Angew. Chem. Int. Ed202059, 3966-3970.

9. Total Synthesis of (−)-Gardmultimine APeiqi Chen, Hesi Yang, Hao Zhang, Wei Chen, Zheng Zhang, Jing Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Lett202022, 2022–2025.

10. A Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation, Hao Zhang, Peiqi Chen, Hesi Yang, Shiqiang Ma, Zemin Wang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem2020, 85, 3954–3962.

11. Synthesis of 2,3-disubstituted indoles via a tandem reaction, Shiqiang Ma, Dan Long, Peiqi Chen, Hongliang Shi, Huilin Li, Ran Fang, Xiaolei Wang, Xingang Xie , and Xuegong She*. Org. Chem. Front20207, 2689-2695.

12. A copper-catalyzed radical coupling/fragmentation reaction: efficient access to β-oxophosphine oxidesShangbiao Feng, Jinlai Li, Feifei He, Tao Li, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front. 2019, 6, 946-951.

13. A concise approach to the tricyclic framework of longipinane- and ent-longipinane-type sesquiterpenoids, Min He, Jiuzhou Yi, Gaoyuan Zhao, Peiqi Chen, Dan Long, Xiaojun Hu, Huilin Li,Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Chem. Front. 20196, 383-387.

14. Total Synthesis of Aspidofractinine Alkaloid Paucidirinine, Weiwei Zhang, Shanhao Lin, Chenglong Du, Shangbiao Feng, Zaimin Liu, Jing Zhang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem. 201984, 1111-1116.

15. Asymmetric Total Synthesis of (+)-Winchinine B, Zaimin Liu, Xiaolin Ju, Shiqiang Ma, Chenglong Du, Weiwei Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. J. Org. Chem. 201984, 14994-15000.

16. Construction of the Tetracyclic Core of Calyciphylline B‑Type Daphniphyllum Alkaloids, Chenglong Du, Jing Fang, Jinyan Chen, Zaimin Liu, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Lett. 2019, 21, 8718−8721. 

17. Bioinspired total synthesis of (−)-gymnothelignan L. Peng Chen, Liang Huo, Huilin Li, Lin Liu, Ziyun Yuan, Hao Zhang, Shangbiao Feng, Xingang Xie, Xiaolei Wang,  and Xuegong She*. Org. Chem. Front. 20185, 1124-1128.

18. Enantioselective Construction of AllCarbon Quaternary Stereogenic Centers by Using Phosphine Catalysis. Huilin Li, and Yixin Lu*. Asian. J. Org. Chem. 20176, 1130-1145.

19. Catalytic Enantioselective AzaPiancatelli Rearrangement. Huilin LiRongbiao Tongand Jianwei Sun*. Angew. Chem. Int. Ed. 201655, 15125-15128.

20. Bioinspired Total Synthesis of Gymnothelignan N. Huilin Li, Yuanyuan Zhang, Xingang Xie, Haichen Ma, Changgui Zhao, Gaoyuan Zhao, and Xuegong She*. Org. Lett. 201416, 4440-4443.

21. Diels–Alder/Oxidative Aromatization Approach towards the AllCarbon DEF Tricyclic Skeleton of Daphenylline. Huilin Li, Yangcheng Qiu, Changgui Zhao, Ziyun Yuan, Xingang Xie, and Xuegong She*. Chem.-Asian J. 20149, 1274-1277.

22. Rapid Construction of the [6665] Tetracyclic Skeleton of the Daphniphyllum Alkaloid Daphenylline. Huilin Li, Jiyue Zheng, Shiyan Xu, Donghui Ma, Changgui Zhao, Bowen Fang, Xingang Xie*, and Xuegong She*. Chem.-Asian J. 20127, 2519-2522.

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