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厍学功

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厍学功

博士、教授、博士生导师

电话:+86-931-8912276

邮箱: shexg@lzu.edu.cn

•教育背景、工作经历

2002-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2001-2002           美国俄勒冈大学,博士后

1999-2001           美国科罗拉多州立大学,博士后

1996-1999           兰州大学,理学博士

1993-1996           西北大学,理学硕士

•荣誉奖励

2017                    国华杰出学者奖领军人才奖

2016                    ACP Lectureship Award

2015                   甘肃省自然科学一等奖

2012                   甘肃省优秀专家

2011                   国家杰出青年基金

2010                   药明康德生命化学研究奖

•研究兴趣

1. 具有良好生物活性复杂天然产物的不对称全合成研究

2. 高效、环境友好的有机合成方法学研究

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•代表成果

1. Recent Advances in Total Synthesis of Diquinane-Containing Natural Products. Huilin Li*, Jing Zhang, and Xuegong She*. Chem.-Eur. J2021, https://doi.org/10.1002/cjoc.202000522

2. Total Synthesis of (-)-Pepluanol B: Conformational Control of the Eight-Membered Ring System. Jing Zhang, Meng Liu, Chuanhua Wu, Gaoyuan Zhao, Peiqi Chen, Lin Zhou, Xingang Xie, Ran Fang, Huilin Li*, and Xuegong She*. Angew. Chem. Int. Ed2020, 59, 3966-3970.

3. Total Synthesis of (−)-Gardmultimine A. Peiqi Chen, Hesi Yang, Hao Zhang, Wei Chen, Zheng Zhang, Jing Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Lett2020, 22, 2022–2025.

4. A Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation. Hao Zhang, Peiqi Chen, Hesi Yang, Shiqiang Ma, Zemin Wang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem2020, 85, 3954–3962.

5. Synthesis of 2,3-disubstituted indoles via a tandem reaction. Shiqiang Ma, Dan Long, Peiqi Chen, Hongliang Shi, Huilin Li, Ran Fang, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front2020, 7, 2689-2695.

6. A copper-catalyzed radical coupling/fragmentation reaction: efficient access to β-oxophosphine oxides. Shangbiao Feng, Jinlai Li, Feifei He, Tao Li, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front. 2019, 6, 946-951.

7. A concise approach to the tricyclic framework of longipinane- and ent-longipinane-type sesquiterpenoids. Min He, Jiuzhou Yi, Gaoyuan Zhao, Peiqi Chen, Dan Long, Xiaojun Hu, Huilin Li,Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Chem. Front. 2019, 6, 383-387.

8. Total Synthesis of Aspidofractinine Alkaloid Paucidirinine. Weiwei Zhang, Shanhao Lin, Chenglong Du, Shangbiao Feng, Zaimin Liu, Jing Zhang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem. 2019, 84, 1111-1116.

9. Asymmetric Total Synthesis of (+)-Winchinine B. Zaimin Liu, Xiaolin Ju, Shiqiang Ma, Chenglong Du, Weiwei Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. J. Org. Chem. 2019, 84, 14994-15000.

10. Construction of the Tetracyclic Core of Calyciphylline B‑Type Daphniphyllum Alkaloids. Chenglong Du, Jing Fang, Jinyan Chen, Zaimin Liu, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Lett. 2019, 21, 8718−8721. 

11. Bioinspired total synthesis of (−)-gymnothelignan L. Peng Chen, Liang Huo, Huilin Li, Lin Liu, Ziyun Yuan, Hao Zhang, Shangbiao Feng, Xingang Xie, Xiaolei Wang,  and Xuegong She*. Org. Chem. Front. 2018, 5, 1124.

12.Total synthesis of conosilane A via a site-selective C–H functionalization strategy. Ziyun Yuan, Xiaojun Hu, Hao Zhang, Lin Liu, Peng Chen, Min He, Xingang Xie, Xiaolei Wang, and Xuegong She*. Chem. Commun. 2018, 54, 912-915.

13.Palladium-Promoted Neutral 1,4-Brook Rearrangement/Intra- molecular Allylic Cyclization Cascade Reaction: A Strategy for the Construction of Vinyl Cyclobutanols. Hao Zhang, Shiqiang Ma, Ziyun Yuan, Peng Chen, Xingang Xie, Xiaolei Wang, and Xuegong She*, Org. Lett. 2017, 19, 3478-3481.

14.(3+2)-Annulation of p‑Quinamine and Aryne: A Strategy To Construct the Multisubstituted Hydrocarbazoles. Dengyu Xu, Yulong Zhao, Dengpeng Song, Zhuliang Zhong, Shangbiao Feng, Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Lett. 2017, 19, 3600−3603.

15.Visible-light-mediated radical insertion/cyclization cascade reaction: synthesis of phenanthridines and isoquinolines from isocyanides. Shangbiao Feng, Tao Li, Chenglong Du, Peng Chen, Dengpeng Song, Jinlai Li, Xingang Xie, and Xuegong She*. Chem. Commun. 2017, 53, 4585-4588.

16.Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids. Gaoyuan Zhao, Xingang Xie, Haiyu Sun, Ziyun Yuan, Zhuliang Zhong, Shouchu Tang, and Xuegong She*. Org. Lett. 2016, 18, 2447-2450.

17.Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B. Dengpeng Song, Zhengshen Wang, Ruoming Mei, Weiwei Zhang, Donghui Ma, Dengyu Xu, Xingang Xie, and Xuegong She*. Org. Lett. 2016, 18, 669-671.

18. Protecting-Group-Free Total Synthesis of (−)-Lycopodine via Phosphoric Acid Promoted Alkyne Aza-Prins Cyclization. Donghui Ma, Zhuliang Zhong, Zaimin Liu, Mingjie Zhang, Shiyan Xu, Dengyu Xu, Dengpeng Song, Xingang Xie, and Xuegong She*. Org. Lett. 2016, 18, 4328−4331.

19. Gold-Catalyzed 1, 2-Acyloxy Migration/Intramolecular [3+2] 1, 3-Dipolar Cycloaddtion Cascade Reaction: An Efficient Strategy for Syntheses of Medium-Sized-Ring Ethers and Amines. Changgui Zhao, Xingang Xie, Shuangshuang Duan, Huilin Li, Ran Fang, and Xuegong She*. Angew. Chem. Int. Ed. 2014, 53, 10789-10793.

20. N‑Heterocyclic Carbene-Catalyzed Formal [3+2] Annulation of Alkynyl Aldehydes with Nitrosobenzenes: A Highly Regioselective Umpolung Strategy. Runfeng Han, Jing Qi, Jixiang Gu, Donghui Ma, Xingang Xie, and Xuegong She*. ACS Catal. 2013, 3, 2705-2709.

21.Pt-Catalyzed Tandem 1, 2-Acyloxy Migration/Intramolecular [3+2] Cycloaddition of Enynyl Esters. Huaiji Zheng, Jiyue Zheng, Binxun Yu, Qiang Chen, Xiaolei Wang, Yongping He, Zhen Yang, and Xuegong She*. J. Am. Chem. Soc. 2010, 132, 1788–1789.

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