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张辅民

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张辅民

博士、教授

电话:+86-931-8912293

传真:+86-931-8912582

邮箱: zhangfm@lzu.edu.cn

•教育背景、工作经历

2014-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2009-2014           兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授

2004-2009           兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师

2001-2004           兰州大学化学化工学院、功能有机分子化学国家重点实验室,助教

2007-2008           美国梅奥医学院 (合作导师: Yuan-Ping Pang),博士后

2003-2006           兰州大学,理学博士

1998-2001           兰州大学,理学硕士

1992-1994           甘肃教育学院

•荣誉奖励

2016                    国家自然科学二等奖(第三完成人)

2015                    教育部自然科学一等奖(第三完成人)

2015                    兰州大学大学生创新创业行动计划“优秀指导教师”

•研究兴趣

活性天然产物和药物的合成及其导向的新合成方法研究

•代表成果 

1. Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine. Qing Zhang, Fu-Min Zhang,* Chang-Sheng Zhang, Si-Zhan Liu, Jin-Miao Tian, Shao-Hua Wang, Xiao-Ming Zhang, Yong-Qiang Tu*, Nat. Commun. 2019, 10, 2507.

2. Transition-Metal-Free α-Arylation of Nitroketones with Diaryliodonium Salts for the Synthesis of Tertiary α-Aryl, α-Nitro Ketones. Yang An, Xiao-Ming Zhang, Ze-Yu Li, Wen-Hui Xiong, Run-Dong Yu, Fu-Min Zhang * Chem. Commun., 2019, 55, 119.

3. Catalytic asymmetric total syntheses of (−)-galanthamine and (−)-lycoramine. Qing Zhang, Fu-Min Zhang,* Chang-Sheng Zhang, Si-Zhan Liu, Jin-Miao Tian, Shao-Hua Wang, Xiao-Ming Zhang, Yong-Qiang Tu*. J. Org. Chem. 2019, 84, 12664.

4. Comprehension of the α-arylation of nitroalkanes. Peng-Fei Zheng, Yang An, Zuo-Yi Jiao*, Zhou-Bao Shi, Fu-Min Zhang*.  Curr. Org. Chem., 2019, 23, 1560.

5. p-Toluenesulfonic Acid Catalysed Fluorination of α-Branched Ketones for the Construction of Fluorinated Quaternary Carbon Centres. Tang, Shi-Zhong; Bian, Hong-Li; Zhan, Zong-Song; Chen, Meng-En; Lv, Jian-Wei; Xie, Shaolei; Zhang, Fu-Min* Chem. Commun., 2018, 54, 12377.

6. Recent Progress in the Isolation, Bioactivity, Biosynthesis, and Total Syntheses of Natural Spiroketals. Zhang, Fu-Min; Zhang, Shu-Yu; Tu, Yong-Qiang* Nat. Prod. Rep. 2018, 35, 75-104.

7. Applications of Ammonium Bifluoride in Organic Synthesis. Li, Jia-Sheng; Dong, Wei-Zhe; Lu, Hui; Zhang, Fu-Min* Curr. Org. Chem. 2018, 22, 581.

8. Copper-Assisted Direct Nitration of Cyclic Ketones with Ceric Ammonium Nitrate for the Synthesis of Tertiary α-Nitro-α-Substituted Scaffolds. Zhang, Z.-Q.; Chen, T.; Zhang, F.-M.* Org. Lett. 2017, 19, 1124-1127.

9. A Simple and Efficient Method for the Preparation of α-Halogenated Ketones Using Iron(III) Chloride and Iron(III) Bromide as Halogen Sources with Phenyliodonium Diacetate as Oxidant. Tang, S.-Z.; Zhao, W.; Chen, T.; Liu, Y.; Zhang, X.-M.; Zhang, F.-M.* Adv. Synth. Cat. 2017, 359, 4177-4183.

10. Iron-Catalyzed α‑Arylation of Deoxybenzoins with Arenes through An Oxidative Dehydrogenative Approach. Chen, T.; Li, Y.-F.; An, Y.; Zhang, F. M.* Org. Lett. 2016, 18, 4754−4757.

11. A Cu-Mediated One-Pot Michael Addition/a-Arylation Strategy Using A Diaryliodonium Salt: A Direct and Efficient Approach to α-Aryl-β-Substituted Cyclic Ketone Scaffolds. Pan, J.-L.; Chen, T.; Zhang, Z.-Q.; Li, Y.-F.; Zhang, X.-M.; Zhang, F.-M.* Chem. Commun. 2016, 52, 2382-2385.

12. NH4HF2 as A Selective TBS-Removal Reagent for the Synthesis of Highly Functionalized Spiroketal via Tandem Deprotection/Spiroketalization Procedure. Lu, H.; Zhang, F.-M.*; Pan, J.-L.; Chen, T.; Li, Y.-F., J. Org. Chem. 2014, 79, 546-558.

13. Towards the Real Didemnaketal A: Total Syntheses of Two C-21 Stereoisomers of the Proposed Didemnaketal A. Zhang, F. M.*; Tu, Y. Q. Tetrahedron Lett. 2014, 55, 3784-3787. 

14. Total Synthesis of the Nominal Didemnaketal A. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D.; Hou, S. H.; Tu, Y. Q.*; Kitching, W. Angew. Chem. Int. Ed. 2012, 51, 10846-10850.

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