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王珠银

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:
王珠银
博士,教授
电话:+86-931-891 2263
 
教育背景、工作经历
2017-至今           兰州大学,功能有机分子化学国家重点实验室,特聘教授。
2014-2016           河海大学,力材学院特聘教授,博导。
2013-2016           南京基诺美生物科技有限公司,总经理
2010-2013           南京金斯瑞生物科技有限公司,副总裁,兼新技术开发部总监。
2007-2009           美国GenScript 公司,研发部总监。  
2006-2007           美国GenScript 公司,蛋白部总监
2004-2006           美国GenScript 公司,主任研究员
1999-2004           美国PharmaSeq, Inc.,高级科学家
1998-1999           哥伦比亚大学(导师: David J. Volsky),博士后
1993-1998           罗格斯大学(导师: Tariq M. Rana),理学博士
1987-1990           兰州大学化学系,理学硕士
1982-1987           兰州大学化学系,理学学士
 
荣誉奖励
2011           入选江苏省“双创计划”
2009           荣获美国 GenScript公司颁发的“创新奖”
1997           荣获美国罗格斯大学“Stanley Mandeles 研究奖”
 
研究兴趣
高通量药物筛选,合成生物学,蛋白质和多肽,多肽药物
 
代表成果
论文:
1. “Effects of  human immunodeficiency virus type 1 on astrocyte gene expression and function: Potential role in neuropathogenesis”.  Zhuying Wang, Gusta Trillo Pazos,Seon Young Kim,Mario Canki,Susan Morgello,Leroy R. Sharer,Harris A. Gelbard,Zaozhong Su,Dongchul Kang,Andrew I. Brooks,Paul B. Fisher,and David J. Volsky*,J. of NeuroVirology, 2004, 10 (Suppl.1),1-8.
2.   “Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp 120”.  Zhuying Wang, Olga Pekarskaya, Meryem Bencheikh, Wei Chao, Harris A. Gelbard, Anuja Ghorpade, Jeffrey D. Rothstein, and David J. Volsky*, Virology, 2003, 312(1),60-73.
3.  “Probing Tat Peptide-TAR Interactions by Psoralen Photo-Cross-Linking”.  Zhuying Wang, Kavita Shah and Tariq M. Rana*, Biochemistry, 2001, 40, 6458-6464.
4.  “Probing RNA-Protein Interaction by Psoralen photocrosslinking”.  Zhuying Wang and Tariq M. Rana*, Methods Mol. Biol., 1999, 118, 49-62.
5.  “Proximity of a Tat peptide to the HIV-1 TAR RNA loop region determined by Site-Specific Photo-Cross-linking”.  Zhuying Wang and Tariq M. Rana*, Bioconjugate Chemistry, 1999, 10, 512-519.
6. “RNA-Protein Interactions in the Tat-TAR Complex Determined by Site-Specific Photocrosslinking”. Zhuying Wang and Tariq M. Rana*, Biochemistry, 1998, 37, 4235-4243.
7. “DNA Damage-Dependent Transcriptional Arrest and Termination of RNA Polymerase II Elongation Complexes in DNA Template Containing HIV-1 Promoter”. Zhuying Wang and Tariq M. Rana*, Proc. Natl. Acad. Sci. USA, 1997, 9, 6688-6693.
8. “RNA Conformation in Tat-TAR Complex Determined by Site-Specific Photocrosslinking”. Zhuying Wang and Tariq M. Rana*, Biochemistry, 1996, 35, 6491-6499.
9.   “Protein Orientation in Tat-TAR Complex Determined by Psoralen Photocrosslinking”. Zhuying Wang and Tariq M. Rana*, J. Biol. Chem., 1996, 271, 16995-16998.
10. “Chemical Conversion of a TAR RNA-Binding Fragment of HIV-1 Tat Protein into a Site-Specific Crosslinking Agent”.  Zhuying Wang, Kavita Shah and Tariq M. Rana*, J. Amer. Chem. Soc., 1995, 117, 5438-5444.
 
美国专利:
1.    “Gel electrophoresis device for loading large sample”. Patent No.: 9,061,236, Zhuying Wang, Hong Qian, Yuanming Liao and Tao Bai, 2015
2.    “Rapid electrophoresis binding method and related kits and compositions”. Patent No.: 8,968,541, Zhuying Wang, Jinyu Yang, Fanli Meng, Bing Lai, Zhan Dai and Fangliang Zhang, 2015   
3.    “Homologous recombination-based DNA cloning methods and compositions”. Patent No.: 8,815,600, Weiqiang Liu, Ping Yang, Tao Wang, Zhuying Wang, Wenzhu Chen and Fangliang Zhang, 2014
4.    “Metal nanoparticle structures for enhancing fluorescence-based assays”.      Patent No.: 8,785,352, W. Mandecki, Ji li and Zhuying Wang, 2014
5.    Methods and compositions for enhanced expression and secretion of proteins”. Patent No.: 8,603,780, Zhuying Wang and Xiaowu Liu, 2013
6.    Homologous recombination-based DNA cloning compositions”. Patent No.: 8,501,454, Weiqiang Liu, Ping Yang, Tao Wang, Zhuying Wang, Wenzhu Chen and Fangliang Zhang, 2013
7.    “Composition Related to Rapid ELISA Process”. Patent No.: 8,334,103,                 Zhuying Wang, Fangliang Zhang and Tao Bai, 2012
8.    Method of Sequence Optimization for improved recombinant protein expression using a particle swarm optimization algorithm”. Patent No.:    8,326,547, Xiaowu Liu, Yun He and Zhuying Wang, 2012
9.    Rapid ELISA processes and related compositions”. Patent No.: 7,824,867,         Zhuying Wang, Fangliang Zhang and Tao Bai, 2010
10.   “Rapid C-ELISA process and related compositions”. Patent No.: 7,816,092,         Zhuying Wang, Fangliang Zhang and Tao Bai, 2010
11.  “Apparatus and method for detecting genetic mutations”. Patent No.: 7,279,280,    Michael Pappas and Zhuying Wang, 2007
 

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