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王锐

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:

王锐,1963年生,博士,教授,博士生导师,中国工程院院士,教育部“长江学者”特聘教授,国家杰出青年科学基金获得者,兰州大学二级教授,甘肃省特聘科技专家。1982年毕业于兰州大学化学系,1988年获兰州大学与日本Kyoto University联合培养博士学位,1990年至1993年先后在兰州大学和美国University of Kansas从事博士后研究。1997年Hong Kong Polytechnic University高级访问学者。1997年至2006年任兰州大学生命科学学院院长,2006年至2008年任兰州大学研究生院副院长,2008年起任基础医学院院长,担任兰州大学新药临床前研究甘肃省重点实验室主任,功能有机分子化学国家重点实验室学术委员会副主任,兰州大学“985工程”医学子平台学术管理委员会主任兼首席专家。
      近三十年从事多肽药物化学和手性药物的不对称合成反应研究。在Chem. Soc. Rev.,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Med. Res. Rev.等刊物上作为通讯作者发表SCI论文228篇,总影响因子大于700分,平均影响因子大于3,其中一区和二区论文70余篇,发表论文被SCI引用2200余次。申请国家发明专利22项(第一发明人),已授权12项,其中1项专利已成功转让并实施于多肽制药生产。作为负责人主持“十一五”和“十二五”“重大新药创制”国家重大科技专项2项、国家自然科学基金重点项目、国家自然科学基金重大研究计划培育项目和集成项目、973前期专项、863课题和7项国家自然科学基金面上项目等多项基金项目。入选国家“百千万人才工程”、教育部“跨世纪优秀人才计划”和中国科学院“百人计划”。兼任国际神经肽学会/生物活性多肽学会中华区主席,教育部科学技术委员会化学学部(第六届)和生命学部(第三届)委员,国家自然科学基金委员会学部专家评审组成员,中国化学会化学生物学专业委员会副主任,甘肃省医学会副会长,中科院兰州化物所羰基合成与选择氧化国家重点实验室学术委员会副主任,香港理工大学手性科学国家重点实验室学术委员会委员及访问教授,国际多肽著名杂志Peptides等四种SCI刊物编委,作为大会主席成功主办第5届(1998年)和第11届(2010年)中国国际多肽学术会议。获中国青年科技奖、高校青年教师奖、国际多肽会议Cathay Award、美国多肽Olson Prize、首届美国Thomson Reuters中国卓越研究奖、甘肃省自然科学一等奖和国家自然科学二等奖(第一完成人)。

Tel: 86-931-8912567, Fax: 86-931-8912567
      Email:
wangrui@lzu.edu.cn

发表论文目录
1.  Zhao DP, Wang Rui* Recent developments in metal catalyzed asymmetric addition of phosphorus nucleophiles. Chem. Soc. Rev., 2011, DOI:10.1039/C1CS15247E (SCI, IF 26.585)
2.  Cao YM, Jiang XX, Liu LP, Shen FF, Zhang FT, Wang Rui*. Enantioselective michael/cyclization reaction sequence: scaffold-inspired synthesis of spirooxindoles with multiple stereocenters. Angew. Chem. Int. Ed., 2011, 50(39): 9124-9127 (SCI, IF 12.730)
3.  Zhang G, Zhang YH, Wang Rui*. Catalytic asymmetric activation of a Csp3-H bond adjacent to a nitrogen atom: a versatile approach to optically active α-alkyl α-amino acids and C1-alkylated tetrahydroisoquinoline derivatives. Angew. Chem. Int. Ed., 2011, 123, 10613-10616 (SCI, IF 12.730)
4.  Liu WX, Wang Rui*. Endomorphins: potential roles and therapeutic indications in the development of opioid peptide analgesic drugs. Med. Res. Rev., 2011, DOI: 10.1002/med.20222 (SCI, IF 10.228)
5.  Zhao DP, Yang DX, Wang YJ, Wang Y, Wang LQ, Mao LJ, Wang Rui* Enantioselective Mannich reaction of a highly reactive Horner–Wadsworth–Emmons reagent with imines catalyzed by a bifunctional thiourea. Chem. Sci., 2011, 2(10): 1918–1921
6.  Jiang XX, Wu LP, Xing YH, Wang L, Wang SL, Chen ZY, Wang Rui* Highly enantioselective Friedel-Crafts alkylation reaction catalyzed by rosin derived tertiary amine-thiourea: synthesis of modified chromanes with anticancer potency. Chem. Commun., 2011, DOI:10.1039/C1CC14379D (SCI, IF 5.787)
7.  Zhao DP, Mao LJ, Wang LQ, Yang DX, Wang Rui* Catalytic asymmetric construction of tetrasubstituted carbon stereocenters by conjugate addition of dialkyl phosphine oxides to β,β-disubstituted α,β-unsaturated carbonyl compounds. Chem. Commun., 2011, accepted, in press, (SCI, IF 5.787)
8.  Jiang XX, Fu D, Shi XM, Wang SL, Wang Rui*. PPh3-catalyzed synthesis of dicyano-2-methylenebut-3-enoates as efficient dienes in catalytic asymmetric inverse-electron-demand Diels-Alder reaction. Chem. Commun., 2011, 47(29): 8289-8291 (SCI, IF 5.787)
9.  Sun WS, Zhu GM, Hong L, Wang Rui* The marriage of organocatalysis with metalcatalysis: access to multi-substituted chiral 2,5-dihydropyrroles by cascade iminium/enamine-metal cooperative catalysis. Chem. Eur. J., 2011, DOI: 10.1002/chem.201103083 (SCI, IF 5.476)
10.  Yang FZ, Xu ZQ*, Wang Z, Yu ZK, Wang Rui*. Copper catalyzed oxidative arylation of heteroarenes under mild conditions and using dioxygen as sole oxidant. Chem. Eur. J., 2011, 17: 6321-6325 (SCI, IF 5.476)
11.  Sun WS, Hong L, Wang Rui*. Facile creation of 2-substituted indolin-3-ones by using primary-secondary diamine catalysts. Chem. Eur. J., 2011, 17: 6030-6033 (SCI, IF 5.476)
12.  Zhang G, Zhang YH, Jiang XX, Yan WJ, Wang Rui*. Highly enantioslective synthesis of multisubstituted polyfunctional dihydropyrrole via an organocatalytic tandem Michael/cyclization sequence. Org. Lett., 2011, 13(15): 3806-3809 (SCI, IF 5.250)
13.  Liu XD, Deng LJ, Song HJ, Jia HZ, Wang Rui*. Asymmetric aza-Mannich addition: synthesis of modified chiral 2-(ethylthio)-thiazolone derivatives with anticancer potency. Org. Lett., 2011, 13: 1494-1497 (SCI, IF 5.250)
14.  Jiang XX, Wang YQ, Zhang G,  Fu D, Zhang FT, Kai M, Wang Rui*. Enantioselective synthesis of cyclic thioureas via Mannich reaction and concise synthesis of highly optically active methylthioimidazolines: discovery of a more potent antipyretic agent. Adv. Synth. Catal., 2011, 353: 1787-1796 (SCI, IF: 5.250)
15.  Zhang W, Song JJ, Zhang BZ, Liu LW, Wang KR, Wang Rui*. Design of acid-activated cell penetrating peptide for delivery of active molecules into cancer cells. Bioconjugate Chem., 2011, 22: 1410-1415 (SCI, IF: 5.002)
16.  Mou LY, Xing YH, Zhou Y, Kong ZQ, Chen ZY, Wang Rui*. The N-terminal domain of human hemokinin-1 influences functional selectivity property for tachykinin receptor neurokinin-1. Biochem. Pharmacol., 2011, 81: 661-668 (SCI, IF 4.889)
17.  Fang Q, Han ZL, Li N, Wang ZL, Wang Rui* Effects of neuropeptide FF system on CB1 and CB2 receptors mediated antinociception in mice. Neuropharmacology, 2011, DOI: 10.1016/j.neuropharm.2011.09.013 (SCI, IF 4.677)
18.  Sun WS, Ma XZ, Hong L, Wang Rui* Asymmetric organocatalytic allylic substitution of Morita-Baylis-Hillman carbonates with allylamines for the synthesis of 2,5-dihydropyrroles. J. Org. Chem., 2011, 76 (19): 7826-7833 (SCI, IF 4.002)
19.  Yang DX, Zhao DP, Mao LJ, Wang LQ, Wang Rui*. Copper/DIPEA-catalyzed, aldehyde-induced tandem decarboxylation-coupling of natural α-amino acids and phosphites or secondary phosphine oxides. J. Org. Chem., 2011, 76(15): 6426-6431 (SCI, IF 4.002)
20.  Yan JX, Wang KR, Chen R, Song JJ, Zhang BZ, Dang W, Zhang W, Wang Rui* Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide. Biochimie., 2011, DOI:10.1016/j.biochi.2011.10.005 (SCI, IF 3.787)
21.  Wang KR1, Yan JX1, Liu X, Zhang JD, Chen R, Zhang BZ, Dang W, Zhang W, Kai M, Song JJ, Wang Rui*. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista. Toxicology., 2011, 288: 27-33 (SCI, IF 3.641)
22.  Lin L, Yin W, Fu X, Zhang JL, Ma XJ, Wang Rui* Asymmetric cyanation of nitroalkenes catalyzed by a salen-titanium catalyst. Org. Biomol. Chem., 2011, DOI: 10.1039/C1OB05899A (SCI, IF 3.451)
23.  Wei P, Liu X, Hu MH, Zuo LM, Kai M, Wang Rui*, Luo SZ* The dimerization interface of the glycoprotein Ibβ transmembrane domain corresponds to polar residues within a leucine zipper motif. Protein Sci., 2011, 20(11): 1814-1823 (SCI, IF 2.741)
24.  Zhang W, Song JJ, Mu LY, Zhang BZ, Liu LW, Xing YH, Wang KR, Li ZY, , Wang Rui*. Improving anticancer activity and selectivity of camptothecin through conjugation with releasable substance P. Bioorg. Med. Chem. Lett., 2011, 21: 1452-1455 (SCI, IF 2.661)
25.  Wang YQ, Wang SB, Ma JL, Guo J, Fang Q, Sun T, Zhuang Y, Wang Rui*. Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice. Peptides, 2011, 32: 702-706 (SCI, IF: 2.654)
26.  Song JJ, Kai M, Zhang W, Zhang JD, Liu LW, Zhang BZ, Liu X, Wang Rui*. Cellular uptake of transportan 10 and its analogs in live cells: Selectivity and structure–activity relationship studies. Peptides, 2011, 32(9): 1934-1941 (SCI, IF: 2.654)
27.  Yao J, Xue Y, Ji F, Wang C, Zhang Y, Ni Jing-man*, Wang Rui*. Protective effects of MLIF analogs on cerebral ischemia-reperfusion injury in rats. Peptides, 2011, 32: 1047-1054 (SCI, IF: 2.654)
28.  Wang CL, Guo C, Wang YQ, Zhou Y, Li Q, Ni Jing-man*, Wang Rui*. Synthesis and antinociceptive effects of endomorphin-1 analogs with C-terminal linked by oligoarginine. Peptides, 2011, 32: 293-299 (SCI, IF: 2.654)
29.  Fang Q, Jiang TN, Li N, Han ZL, Wang Rui*. Central Administration of Neuropeptide FF and Related Peptides Attenuate Systemic Morphine Analgesia in Mice. Protein Pept. Lett., 2011, 18: 403-409 (SCI, IF: 1.849)2010
30.  Jiang XX, Cao YM, Wang YQ, Liu LP, Shen FF, Wang Rui*. A Unique Approach to the Concise Synthesis of Highly Optically Active Spirooxazolines and the Discovery of a More Potent Oxindole-Type Phytoalexin Analogue. J. Am. Chem. Soc., (Article), 2010, 132: 15328-15333 (SCI, IF 9.019)
31.  Hong L, Sun W, Liu CX, Zhao DP, Wang Rui* Enantioselective construction of allylic phosphine oxides through substitution of Morita–Baylis–Hillman carbonates with phosphine oxides. Chem. Commun., 2010, 46: 2856-2858 (SCI, IF 5.787)
32.  Jiang XX, Fu D, Zhang G, Cao Y, Liu L, Song J, Wang Rui*. Highly diastereo- and enantioselective Mannich reaction of lactones with N-Boc-aldimines catalyzed by bifunctional rosin-derived amine thiourea catalysts. Chem. Commun., 2010, 46: 4294-4296 (SCI, IF 5.787)
33.  Hong L, Sun W, Liu CX, Wang L, Wang Rui* Asymmetric Organocatalytic N-Alkylation of Indole-2-carbaldehydes with alpha,beta-Unsaturated Aldehydes: One-Pot Synthesis of Chiral Pyrrolo[1,2-a]indole-2-carbaldehydes. Chem. Eur. J., 2010, 16: 440-444 (SCI, IF 5.476)
34.  Liu CL, Zhang XS, Wang Rui*, Wang Wei*. Figure 1 “One-Pot” Access to 4H-Chromenes with Formation of a Chiral Quaternary Stereogenic Center by a Highly Enantioselective Iminium-allenamine Involved Oxa-Michael?Aldol Cascade. Org. Lett., 2010, 12: 4948-4951 (SCI, IF 5.250)
35.  Sun WS, Hong L, Liu C, Wang Rui*. Base-accelerated enantioselective substitution of Morita-Baylis-Hillman carbonates with dialkyl phosphine oxides. Org. Lett., 2010, 12: 3914-3917 (SCI, IF 5.250)
36.  Jiang XX, Zhang G, Fu D, Cao YM, Shen FF, Wang Rui* Direct organocatalytic asymmetric aldol reaction of r-isothiocyanato imides to r-ketoesters under low ligand loading: a doubly stereocontrolled approach to cyclic thiocarbamates bearing chiral quaternary stereocenters. Org. Lett., 2010, 12: 1544-1547 (SCI, IF 5.250)
37.  Liu XD, Deng LJ, Jiang XX, Yan WJ, Liu CL, Wang Rui* Asymmetric aza-mannich addition of oxazolones to N-tosyl aldimines: synthesis of chiral α-disubstituted α,β-diamino acids. Org. Lett., 2010, 12: 876-879 (SCI, IF 5.250)
38.  Zhao DP, Mao LJ, Wang Y, Yang DX, Zhang QL, Wang Rui* Catalytic asymmetric hydrophosphinylation of a,β-unsaturated N-acylpyrroles: application of dialkyl phosphine qxides in enantioselective synthesis of chiral phosphine qxides or phosphines. Org. Lett., 2010, 12: 1880-1882 (SCI, IF 5.250)
39.  Mao ZF, Jia YM, Li WY, Wang Rui*. Water-Compatible Iminium Activation: Highly Enantioselective Organocatalytic Michael Addition of Malonates to α,β-Unsaturated Enones. J. Org. Chem., 2010, 75: 7428-7230 (SCI, IF 4.002)
40.  Liu Y, Da CS*, Yu SL, Yin XG, Wang JR, Fan XY, Li WP, Wang Rui*. Catalytic Highly Enantioselective Alkylation of Aldehydes with Deactivated Grignard Reagents and Synthesis of Bioactive Intermediate Secondary Arylpropanols. J. Org. Chem., 2010, 75: 6869-6878 (SCI, IF 4.002)
41.  Zhao DP, Mao L, Yang D, Wang Rui*. Zinc-Mediated Asymmetric Additions of Dialkylphosphine Oxides to α,β-Unsaturated Ketones and N-Sulfinylimines, J. Org. Chem., 2010, 75: 6756-6763 (SCI, IF 4.002)
42.  Jiang XX, Zhang BZ, Zhang YF, Lin L, Yan WJ, Wang Rui*. Direct asymmetric michael addition of thioether-based aryl sulfanyl-propan-2-one to nitroalkenes catalyzed by a chiral amine-thiourea bifunctional organocatalyst. Chirality, 2010, 22: 625-634 (SCI, IF 2.892)
43.  Dai X, Song HJ, Cui SG, Wang T, Liu Q, Wang Rui*. The stimulative effects of endogenous opioids on endothelial cell proliferation, migration and angiogenesis in vitro. Eur. J. Pharmacol., 2010, 628: 42-50 (SCI, IF 2.737)
44.  Zhang W, Li J, Liu LW, Wang KR, Song JJ, Yan JX, Li ZY, Zhang BZ, Wang Rui*. A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. Peptides, 2010, 31: 1832-1838 (SCI, IF 2.654)
45.  Zhang BZ1, Wang KR1, Yan JX, Zhang W, Song JJ, Ni JM, Wang Rui* In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. Peptides, 2010, 31: 568-573 (SCI, IF 2.654)
46.  Peng YL, Han RW, Chang M, Zhang L, Zhang RS, Li W, Han YF, Wang Rui*. Central Neuropeptide S inhibits food intake in mice through activation of Neuropeptide S receptor. Peptides, 2010, 31: 2259-2263 (SCI, IF 2.654)
47.  Peng YL, Zhang JN, Chang M, Li W, Han RW, Wang Rui*. Effects of central neuropeptide S in the mouse formalin test. Peptides, 2010, 31: 1878-1883 (SCI, IF 2.654)
48.  Fang Q, Li N, Jiang TN, Liu Q, Li YL, Wang Rui*. Pressor and tachycardic responses to intrathecal administration of neuropeptide FF in anesthetized rats. Peptides. 2010, 31: 683-688 (SCI, IF 2.654)
49.  Yan WJ, Li P, Feng JC, Wang D, Zhu SQ, Jiang XX, Wang Rui*. Design and synthesis of a tridentate ligand inspired by the phenomenon of self-assembly catalysis and its application in the asymmetric alkynylation of N-(diphenylphosphinoyl) imines. Tetrahedron: Asymmetry, 2010, 16: 2037-2042. (SCI, IF 2.484)
50.  Sun WS, Hong L, Liu CX, Wang Rui* Asymmetric construction of quaternary stereocenters by direct conjugate addition of oxindoles to enone. Tetrahedron:Asymmetry, 2010, 21: 2493-2497 (SCI, IF 2.484)
51.  Kong ZQ, Yang WL, Tao Y, Shi XM, Fu CY, Zhao RF, Wang Rui* Effects of rat/mouse hemokinin-1, human hemokinin-1 and human hemokinin-1(4-11), mammalian tachykinin peptides, on rate and perfusion pressure in the isolated guinea pig heart. Neuropeptides, 2010, 44: 437-444 (SCI, IF 1.917)
52.  a) Lin L, Li AN, Zhao QY, Yang FZ, Yin W, Wang Rui* Asymmetric synthesis of Anomala Osakana Pheromone isomer using protecting group free strategy. Chin. Sci. Bull., 2010, 55: 2811-2813 (SCI, IF 1.087) b) 林利, 李阿妮, 赵庆阳, 杨帆致, 尹稳, 王 锐*,无保护基策略不对称合成大阪金龟信息素异构体,科学通报,2010, 55: 2453-2455

 

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