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李 瀛

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:
李  瀛
博士、教授
电话:+86-931-8912788
邮箱:liying@lzu.edu.cn
 
教育背景、工作经历
1997-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授
1985-1997           兰州大学化学系、应用有机化学国家重点实验室,副教授
1985-1992           兰州大学化学系,讲师
1977-1985           兰州大学化学系,助教
1990-1993           兰州大学,理学博士
1985-1989           兰州大学,理学硕士
1974-1977           兰州大学,理学学士
 
荣誉奖励
2009                    国家科技进步二等奖(第二完成人)
2008                    教育部科技进步一等奖(第二完成人)
2005                    享受国务院政府特殊津贴
2001                    国家教委科技进步二等奖(第三完成人)
1997                    宝钢教育奖学金优秀教师奖
1994                    国家教委科技进步二等奖(第二完成人)
 
研究兴趣
具有重要生物活性天然产物的全合成;以新药开发为导向的应用研究
 
代表成果
1.“Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores.” Xue, J.*; Zhang, H.; Tian, T.; Yin, K.; Liu, D.; Jiang, X.*; Li, Y.*; Jin, X.; Yao, X. Adv. Synth. Catal. 2016, 358, 370-374.
2.“Alkynylation/Dearomatizative Cyclization to Construct Spiro 5.5 Undecanes.”Shao, J.; Li, L.*; Zhang, J.; Hu, J.; Xue, J.; Li, Y.* RSC Adv. 2016, 6, 31363-31366.
3.“Mg(ClO4)2-Promoted [4 + 3] Cycloaddition of Oxindole Derivatives with Conjugated Dienes: Concise Synthesis of Spirocycloheptane Oxindole Derivatives.”Liu, Y.; Sun, Z.; Li, S.; Xiang, K.; Zhang, Y.*; Li, Y.* RSC Adv. 2016, 6, 26954-26958.
4.“TMSI-Promoted Vinylogous Michael Addition of Siloxyfuran to 2-Substituted Chromones: A General Approach for the Total Synthesis of Chromanone Lactone Natural Products.”Liu, J.; Li, Z.; Tong, P.; Xie, Z.; Zhang, Y.*; Li, Y.* J. Org. Chem. 2015, 80, 1632-1643.
5.“Enantioselective Syntheses of Spiroketals via a Tandem Reaction of Cu(I)-Catalyzed Cycloetherification and Hydrogen-Bond-Induced [4 + 2] Cyclization.”Tian, T.; Li, L.; Xue, J.; Zhang, J.; Li, Y. J. Org. Chem. 2015. 80, 4189–4200.
6.“One Pot Hydroamination/ 4+3 Cycloaddition: Synthesis towards the Cyclohepta b Indole Core of Silicine and Ervatamine.”Zhang, J.; Shao, J.; Xue, J.*; Wang, Y.; Li, Y.* RSC Adv. 2014, 4, 63850-63854.
7.“Total Synthesis of Aphadilactones A–D.”Yin, J.-P.; Gu, M.; Li, Y.*; Nan, F.-J.* J. Org. Chem. 2014, 79, 6294-6301.
8.“Ivorenolide B, An Immunosuppressive 17-Membered Macrolide from Khaya ivorensis: Structural Determination and Total Synthesis.”Wang, Y.; Liu, Q.-F.; Xue, J.-J.; Zhou, Y.; Yu, H.-C.; Yang, S.-P.; Zhang, B.; Zuo, J.-P.; Li, Y.*; Yue, J.-M.* Org. Lett. 2014, 16, 2062-2065.
9.“Total Synthesis of (+/-)-delta-Rubromycin.”Wang, W.; Xue, J.*; Tian, T.; Zhang, J.; Wei, L.; Shao, J.; Xie, Z.; Li, Y.* Org. Lett. 2013, 15, 2402-2405.
10.“The First Asymmetric Total Synthesis of (+)-Coriandrone A and B.”Wang, W.; Xue, J.*; Tian, T.; Jiao, Y.; Li, Y.* Org. Biomol. Chem. 2013, 11, 6686-90.
11.“Regio- and Stereoselective 4+3 Cycloaddition Towards Fused 5,7,6-Tricyclic Skeletons.”Gong, W.; Liu, Y.; Zhang, J.; Jiao, Y.; Xue, J.*; Li, Y.* Chem. Asian J. 2013, 8, 546-551.
12.“A Novel, Facile Approach to Frondosin B and 5-epi-Liphagal via a New 4+3 -Cycloaddition.”Zhang, J.; Li, L.; Wang, Y.; Wang, W.; Xue, J.*; Li, Y.* Org. Lett. 2012, 14, 4528-4530.
13.“Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis.”Zhang, B.; Wang, Y.; Yang, S.-P.; Zhou, Y.; Wu, W.-B.; Tang, W.; Zuo, J.-P.; Li, Y.*; Yue, J.-M.* J. Am. Chem. Soc. 2012, 134, 20605-20608.
14.“Construction of Aromatic 5,5 Spiroketals via Hypoiodite-Catalyzed Etherification Combined in Relay Cascades.”Wei, W.; Wang, Y.; Yin, J.; Xue, J.*; Li, Y.* Org. Lett. 2012, 14, 1158-1161.
15.“New Fluoride-Promoted Hypoiodite-Catalytic Oxidative Cycloetherification to Aromatic Spiroketals.”Wei, W.; Li, L.; Lin, X.; Li, H.; Xue, J.*; Li, Y.* Org. Biomol. Chem. 2012, 10, 3494-3499.
16.“Synthesis of (+/-)-gamma-Rubromycin via a New Hypoiodite-Catalytic Oxidative Cycloetherification.”Wei, L.; Xue, J.*; Liu, H.; Wang, W.; Li, Y.* Org. Lett. 2012, 14, 5302-5305.
17.“Copper(I)-Catalyzed Hydroalkoxylation/Hydrogen-Bonding-Induced Asymmetric Hetero-Diels-Alder Cycloaddition Cascade: An Approach to Aromatic Spiroketals.” Li, X.; Xue, J.*; Huang, C.; Li, Y. Chem. Asian J. 2012, 7, 903-906.
18.“Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A.”Du, C.; Li, L.; Li, Y.; Xie, Z.* Angew. Chem., Int. Edit. 2009, 48 , 7853-7856.
19. ”An Efficient Synthesis of Highly Functionalized 5,6 Aromatic Spiroketals by Hetero-Diels-Alder Reaction.”Zhou, G.; Zhu, J.; Xie, Z.*; Li, Y.* Org. Lett. 2008, 10, 721-724.
20. “Total Synthesis of (+/-)-Quadrangularin A.”Li, W.; Li, H.; Li, Y.; Hou, Z.* Angew. Chem., Int. Edit. 2006, 45, 7609-7611.
 

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