收藏本站| 设为首页| 联系我们| English Version
您的位置:网站首页 > 学术队伍 > 教授 > 正 文

周 波

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:
周  波
博士、教授
电话:+86-13639330926
邮箱:bozhou@lzu.edu.cn
 
教育背景、工作经历
2004-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授
2000-2004           兰州大学生命科学院、功能有机分子化学国家重点实验室,博士后
1997-2000           兰州大学,理学博士
1994-1997           兰州大学,理学硕士
1989-1993           赣南师范大学,学士
 
荣誉奖励
2014                   中国环境诱变剂学会活性氧生物学效应专业委员会常务委员
2013                   中国生物物理学会自由基生物学与自由基医学分会理事
2006                   2006年入选教育部“新世纪优秀人才支持计划”
 
研究兴趣
主要研究领域为:自由基化学和自由基生物学、化学生物学、生物有机和药物化学。主要研究兴趣集中于:基于癌细胞的氧化还原特征设计天然产物导向的促氧化抗癌分子。
 
代表成果
1. “Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores”. Dai, F.; Yan, W.-J.; Du, Y.-T.; Bao, X.-Z.; Li, X.-Z.; Zhou, B.* Free Radic. Biol. Med. 2017, 108, 554-563.
2. “Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death”. Tu, Z.-S.; Wang, Q.; Sun, D.-D.; Dai, F. *; Zhou, B.* Eur. J. Med. Chem. 2017, 134, 72-85.
3. “Developing piperlongumine-directed glutathione S-transferase inhibitors by an electrophilicity-based strategy”. Wang, H.-B.; Jin, X.-L.; Zheng, J.-F.; Wang, F.; Dai, F.; Zhou, B.* Eur. J. Med. Chem. 2017, 126, 517-525.
4. “Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation”. Yan, W.-J.; Wang, Q.; Yuan, C.-H.; Wang, F.;  Ji, Y.; Dai, F.; Jin, X.-L.; Zhou, B.* Free Radic. Biol. Med. 2016, 97, 109-123.
5. “Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog”. Lin, D.; Dai, F.*; Sun, L.-D.; Zhou, B.* Mol. Nutr. Food Res. 2015, 59, 2395-2406.
6. “Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention”. Li, Y.; Zhang, L.-P.; Dai, F.; Yan, W.-J.; Wang, H.-B.; Tu, Z.-S.; Zhou, B.* J. Agric. Food Chem. 2015, 63, 7731-7742.
7. “A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Respons”. Shen, T.; Jiang, T.; Long, M.; Chen, J.; Ren, D.-M.; Wong, P. K.; Chapman, E.*; Zhou, B.*; Zhang, D. D.* Antioxid. Redox Signal. 2015, 23, 651-664.
8. “Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids”. Dai, F.; Liu, G.-Y.; Li. Y.; Yan, W.-J.; Wang, Q.; Yang, J.; Lu, D.-L.; Ding, D.-J.; Lin, D.; Zhou, B.* Free Radic. Biol. Med. 2015, 85, 127-137.
9. “Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent”. Sun, L.-D.; Wang, F.; Dai, F.; Wang, Y.-H.; Lin, D.; Zhou, B.* Biochem. Pharmacol. 2015, 95, 156-169.
10. “Tailoring 3,3’-Dihydroxyisorenieratene to Hydroxystilbene: Finding a Resveratrol Analogue with Increased Antiproliferation Activity and Cell Selectivity”. Kang, Y. F.; Yan, W.-J.; Zhou, T.-W.; Dai, F.; Li, X.-Z.; Bao, X.-Z.; Du, Y.-T.; Yuan, C.-H.; Wang, H.-B.; Ren, X.-R.; Liu, Q.; Jin, X.-L.; Zhou, B.*; Zhang, J.* Chem. Eur. J. 2014, 20, 8904-8908.
 

教授

版权所有:兰州大学功能有机分子化学国家重点实验室 办公电话:0931-8912500
Copyrights (C) 2010 State Key Laboratory of Applied Organic Chemistry, Lanzhou University All Rights Reserved