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戴 芳

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:
戴  芳
博士、副教授
电话:+86-13679423578
邮箱:daifang@lzu.edu.cn
 
教育背景、工作经历
2008/05-至今                兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授
2007/01-2008/04          兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师
2004/09-2006/11          兰州大学化学化工学院、功能有机分子化学国家重点实验室,博士后
2004/06                        天津医科大学,博士学位
 
研究兴趣
长期从事分子和细胞生物学相关研究工作,目前的研究兴趣集中于:(1)线粒体靶向的促氧化抗癌分子设计及其机制研究;(2)检测细胞氧化还原状态的荧光探针设计。
 
代表成果
1. “Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores”. Dai, F.;Yan, W.-J.;Du, Y.-T.;Bao, X.-Z.; Li, X.-Z.; Zhou, B.* Free Radic. Biol. Med. 2017, 108, 554-563.
2. Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death”. Tu, Z.-S.; Wang, Q.; Sun, D.-D.; Dai, F.*; Zhou, B.* Eur. J. Med. Chem. 2017, 134, 72-85.
3. “Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids”. Dai, F.; Liu, G.-Y.; Li. Y.; Yan, W.-J.; Wang, Q.; Yang, J.; Lu, D.-L.; Ding, D.-J.; Lin, D.; Zhou, B.* Free Radic. Biol. Med. 2015, 85, 127-137.
4. “Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog”. Lin, D.; Dai, F.*; Sun, L.-D.; Zhou, B.* Mol. Nutr. Food Res. 2015, 59, 2395-2406.
5. “3,4-dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells”. Zhang, L.*; Jing, H.; Cui, L.; Li, H.; Zhou, B.; Zhou, G.; Dai, F.* J.Cell Biochem. 2013, 114, 697-707.
6. “Antioxidative Effects of Curcumin and its Analogues against the Free-radical-induced Peroxidation of Linoleic Acid in Micelles”. Dai F.; Chen W.-F.; Zhou B.*; Yang L.; Liu Z.-L. Phytother.Res. 2009, 23, 1220-1228.
7. “Antioxidant synergism of green tea polyphenols with a-tocopherol and L-ascorbic acid in SDS micelles”, Dai F.; Chen W.-F.; Zhou B.* Biochimie 2008, 90, 1499-1505.
 

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