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涂永强

【来源:功能有机分子化学国家重点实验室 | 发布日期: | 作者: 】     【选择字号:
涂永强
中国科学院院士、博士、教授
电话:+86-931-8912293
传真:+86-931-8912582
邮箱:tuyq@lzu.edu.cn
 
教育背景、工作经历
1996-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授
2004-2005           德国比勒费尔德大学,访问教授
1992-1995           澳大利亚昆士兰大学(合作导师: W. Kitching),博士后
1989-1992           兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师,副教授
1986-1989           兰州大学,理学博士
1985-1986           四川大学华西药学院,助教
1982-1985           兰州大学,理学硕士
1978-1982           兰州大学,学士
         
荣誉奖励
2016                    国家自然科学二等奖(第一完成人)
2015                    教育部自然科学一等奖(第一完成人)
2015                    中国化学会 “维善合成成就奖”
2012                    “全国优秀科技工作者”
2006                    甘肃省 “自然科学一等奖”
2005                    美国Lilly公司 “杰出科研成就奖”
2004                    教育部 “长江学者特聘教授”
2002                    甘肃省 “科技进步一等奖”
2001                    国家自然科学基金委 “创新群体” (学术带头人,连续三期资助)
2000                    香港求是科技基金会 “杰出青年学者奖”
2000                    国家自然科学基金委 “杰出青年基金”资助
1996                    国家 “百千万人才工程”
1993                    中国化学会 “优秀青年化学奖”
 
研究兴趣
具有重要生物活性的天然产物全合成
手性氮杂螺环配体(催化剂)的设计、合成及催化不对称反应研究
 
代表成果
1.     Recent Progress in the Isolation, Bioactivity, Biosynthesis, and Total Syntheses of Natural Spiroketals. Zhang, F.-M.; Zhang, S.-Y.; Tu, Y.-Q.* Nat. Prod. Rep. 2018, Accepted.
2.     Recent Applications of the 1,2-Carbon Atom Migration Strategy in Complex Natural Product Total Synthesis. Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H. Chem. Soc. Rev., 2017, 46, 2272-2305.
3.     Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B.       Hou, S.-H.; Tu, Y.-Q.*; Wang, S.-H.; Xi, C.-C.; Zhang, F.-M.; Wang, S.-H.; Li, Y.-T.; Liu, L. Angew. Chem. Int. Ed. 2016, 55, 4456-4460.
4.     Radical Aryl Migration Reactions and Synthetic Applications. Chen, Z.-M.; Zhang, X.-M.; Tu, Y.-Q.* Chem. Soc. Rev. 2015, 44, 5220.-5245
5.     Tandem C-H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (-)-brussonol and (-)-przewalskine E. Jiao, Z.-W.; Tu, Y.-Q.*; Zhang, Q.; Liu, W.-X.; Zhang, S.-Y.; Wang, S.-H.; Zhang, F.-M.; Jiang, S. Nat. Commun. 2015, 6, 7332.
6.     Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4]nonane-1,6-diones. Yang, B.-M.; Cai, P.-J.; Tu, Y.-Q.*; Yu, Z.-X.; Chen, Z.-M.; Wang, S.-H.; Wang, S.-H.; Zhang, F.-M. J. Am. Chem. Soc. 2015, 137, 8344-8347.
7.     Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Hou, S. H.; Tu, Y.-Q.*; Liu, L.; Zhang, F. M.; Wang, S. H.; Zhang, X. M. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.
8.     Copper-Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols. Chen, Z. M.; Bai, W.; Wang, S. H.; Yang, B. M.; Tu, Y.-Q.*; Zhang, F. M. Angew. Chem. Int. Ed. 2013, 52, 9781-9785.
9.     Total Synthesis of the Nominal Didemnaketal A. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D.; Hou, S. H.; Tu, Y.-Q.*; Kitching, W. Angew. Chem. Int. Ed. 2012, 51, 10846-10850.
10.   Organocatalytic Asymmetric Direct Csp3-H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers. Jiao, Z. W.; Zhang, S. Y.; He, C.; Tu, Y.-Q.*; Wang, S. H.; Zhang, F. M.; Zhang, Y. Q.; Li, H. Angew. Chem. Int. Ed. 2012, 51, 8811-8815.
11.   Total Synthesis of (+/-)-Alopecuridine and Its Biomimetic Transformation into (+/-)-Sieboldine A. Zhang, X. M.; Tu, Y.-Q.*; Zhang, F. M.; Shao, H.; Meng, X. Angew. Chem. Int. Ed. 2011, 50, 3916-3919.
12.   Direct Sp3 alpha-C-H Activation and Functionalization of Alcohol and Ether. Zhang, S. Y.; Zhang, F. M.; Tu, Y.-Q.*Chem. Soc. Rev. 2011, 40, 1937-1949.
13.   Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Wang, B. M.; Tu, Y.-Q.* Acc. Chem. Res. 2011, 44, 1207-1222.
14.   Semipinacol Rearrangement in Natural Product Synthesis. Song, Z. L.; Fan, C. A.; Tu, Y.-Q.* Chem. Rev. 2011, 111, 7523-7556.
15.   Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral alpha-Oxa-Quaternary beta-Haloketones. Chen, Z. M.; Zhang, Q. W.; Chen, Z. H.; Li, H.; Tu, Y.-Q.*; Zhang, F. M.; Tian, J. M. J. Am. Chem. Soc. 2011, 133, 8818-8821.
16.   Iron-Catalyzed C(sp(3))-C(sp(3)) Bond Formation through C(sp(3))-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes. Zhang, S. Y.; Tu, Y.-Q.*; Fan, C. A.; Zhang, F. M.; Shi, L. Angew. Chem. Int. Ed. 2009, 48, 8761-8764.
17.   Bronsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers. Zhang, Q. W.; Fan, C. A.; Zhang, H. J.; Tu, Y.-Q.*; Zhao, Y. M.; Gu, P.; Chen, Z. M. Angew. Chem. Int. Ed. 2009, 48, 8572-8575.
18.   Organocatalytic Asymmetric Vinylogous alpha-Ketol Rearrangement: Enantioselective Construction of Chiral All-Carbon Quaternary Stereocenters in Spirocyclic Diketones via Semipinacol-Type 1,2-Carbon Migration. Zhang, E.; Fan, C. A.; Tu, Y.-Q.*; Zhang, F. M.; Song, Y. L. J. Am. Chem. Soc. 2009, 131, 14626-14627.
19.   A Reaction for sp(3)-sp(3) C-C Bond Formation via Cooperation of Lewis Acid-Promoted/Rh-Catalyzed C-H Bond Activation. Shi, L.; Tu, Y.-Q.*; Wang, M.; Zhang, F. M.; Fan, C. A.; Zhao, Y. M.; Xia, W. J. J. Am. Chem. Soc. 2005, 127, 10836-10837.
20.   A Tandem Semipinacol Rearrangement/Alkylation of alpha-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1,3-Diols. Hu, X. D.; Fan, C. A.; Zhang, F. M.; Tu, Y.-Q.* Angew. Chem. Int. Ed. 2004, 43, 1702-1705.
21.   Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of alpha-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1,3-Diol Units. Fan, C. A.; Wang, B. M.; Tu, Y.-Q.*; Song, Z. L. Angew. Chem. Int. Ed. 2001, 40, 3877-3880.
22.   Stereoselective Reductive Rearrangement of alpha-Hydroxy Epoxides: A New Method for Synthesis of 1,3-Diols. Tu, Y.-Q.*; Sun, L. D.; Wang, P. Z. J. Org. Chem. 1999, 64, 629-633.
 

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