涂永强 中国科学院院士、博士、教授、博士生导师 电话：+86-931-8912293 传真：+86-931-8912582 邮箱：tuyq@lzu.edu.cn

·教育背景、工作经历

1996-至今       兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授

2004-2005      德国比勒费尔德大学，访问教授

1992-1995      澳大利亚昆士兰大学（合作导师: W. Kitching），博士后

1989-1992      兰州大学化学化工学院、功能有机分子化学国家重点实验室，讲师，副教授

1986-1989      兰州大学，理学博士

1985-1986      四川大学华西药学院，助教

1982-1985      兰州大学，理学硕士

1978-1982      兰州大学，学士

·荣誉奖励

       2022               何梁何利基金“科学与技术进步奖”

       2022               中国化学会手性化学奖             

2016               国家自然科学二等奖（第一完成人）

2015               教育部自然科学一等奖（第一完成人）

2015               中国化学会 “维善合成成就奖”

2012              “全国优秀科技工作者”

2006               甘肃省 “自然科学一等奖”

2005               美国Lilly公司 “杰出科研成就奖”

2004               教育部 “长江学者特聘教授”

2002               甘肃省 “科技进步一等奖”

2001               国家自然科学基金委 “创新群体” （学术带头人，连续三期资助）

2000               香港求是科技基金会 “杰出青年学者奖”

2000               国家自然科学基金委 “杰出青年基金”资助

1996               国家 “百千万人才工程”

1993               中国化学会 “优秀青年化学奖”

·研究兴趣

具有重要生物活性的天然产物全合成

手性氮杂螺环配体（催化剂）的设计、合成及催化不对称反应研究

·代表成果

1. An Effective and Versatile Strategy for the Synthesis of Structurally Diverse Heteroarylsilanes via Ir(III)-Catalyzed C-H Silylation. Zhi-Bo Yan, Meng Peng, Qi-Long Chen, Ka Lu, Yong-Qiang Tu*, Kun-Long Dai, Fu-Min Zhang, Xiao-Ming Zhang, Chem. Sci. 2021, 12, 9748-9753.

2. Enantioselective Construction of 2-Aryl-2,3-dihydrobenzofuran Scaffolds Using Cu/SPDO-Catalyzed [3 + 2] Cycloaddition. Ze-Ran Jing, Dong-Dong Liang, Jin-Miao Tian*, Fu-Min Zhang*, Yong-Qiang Tu*, Org. Lett. 2021, 23, 1258-1262.

3. Remote Asymmetric Conjugate Addition Catalyzed by a Bifunctional Spiro-Pyrrolidine-Derived Thiourea Catalyst. Ming-Hui Xu, Yong-Hai Yuan, Dong-Dong Liang, Xiao-Ming Zhang*, Fu-Min Zhang, Yong-Qiang Tu*, Ai-Jun Ma, Kun Zhang, Jin-Bao Peng, Org. Chem. Front. 2021, 8, 3292-3297.

4. Collective Total Synthesis of Aspidofractinine Alkaloids through the Development of a Bischler-Napieralski/Semipinacol Rearrangement Reaction. Shuanghu Wang, Ruiqi Si, Qingbo Zhuang, Xiang Guo, Tian Ke, Xiaoming Zhang*, Fumin Zhang*, and Yongqiang Tu*. Angew. Chem. Int. Ed. 2020, 59, 21954-21958.

5. Enantioselective Catalytic Aldehyde α-Alkylation/Semipinacol Rearrangement: Construction of α-Quaternary-δ-Carbonyl Cycloketones and Total Synthesis of (+)-Cerapicol. Jie Yang, Xiaoming Zhang*, Fumin Zhang, Shaohua Wang, Yongqiang Tu*, Zhen Li, Xichao Wang, and Hong Wang. Angew. Chem. Int. Ed. 2020, 59, 8471-8475.

6. Facile Access to Diverse All-Carbon Quaternary Center Containing Spirobicycles by Exploring a Tandem Castro-Stephens Coupling/Acyloxy Shift/ Cyclization/Semipinacol Rearrangement Sequence. Ye Zhang, Tianlu Zheng, Fu Cheng, Kunlong Dai, Kun Zhang, Aijun Ma, Fumin Zhang, Xiaoming Zhang, Shaohua Wang*, and Yongqiang Tu*. Chem. Sci. 2020, 11, 3878-3884.

7. Development of Unique Dianionic Ir(III) CCC Pincer Complexes with a Favourable Spirocyclic NHC Framework. Zhibo Yan, Kunlong Dai, Binmiao Yang, Zihao Li, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, Meng Peng, Qilong Chen and Zeran Jing. Sci. China Chem. 2020, 63, 1761-1766.

8. Atroposelective Synthesis of Axially Chiral 3‑Arylindoles by Copper-Catalyzed Asymmetric Cross-Coupling of Indoles with Quinones and Naphthoquinones. Chaochao Xi, Xiaojing Zhao, Jinmiao Tian*, Zhimin Chen*, Kun Zhang, Fumin Zhang, Yongqiang Tu*, and Jiawei Dong. Org. Lett. 2020, 22, 4995-5000.

9. Construction of Polyfunctionalized 6-5-5 Fused Tricyclic Carbocycles via One-Pot Sequential Semipinacol Rearrangement/Michael Addition/Henry Reaction. Fuping Zhu, Xiang Guo, Fumin Zhang*, Xiaoming Zhang, Hongwang and Yongqiang Tu*. Org. Lett. 2020, 22, 2076-2080.

10. Exploration of a KI-Catalyzed Oxidation System for Direct Construction of Bispyrrolidino[2,3-b]indolines and the Total Synthesis of (+)-WIN 64821. Sikai Chen, Jusong Yang, Kunlong Dai, Fumin Zhang*, Xiaoming Zhang*, and Yongqiang Tu*. Chem. Commun. 2020, 56, 121-124.

11. Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II. Yonghai  Yuan, Xue Han, Fuping Zhu, Jinmiao Tian, Fumin Zhang, Xiaomin Zhang, Yongqiang Tu*, Shaohua Wang, and Xiang Guo, Nat. Commun., 2019, 10, 3394.

12. Copper‐Complex‐Catalyzed Asymmetric Aerobic Oxidative Cross‐Coupling of 2‐Naphthols: Enantioselective Synthesis of 3,3′‐Substituted C1‐Symmetric BINOLs. Jinmiao Tian, Aifang Wang, Jusong Yang, Xiaojin Zhao, Yongqiang Tu*, Shuyu Zhang, and Zhimin Chen. Angew. Chem. Int. Ed., 2019, 58, 11023.

13. Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine. Qing Zhang, Fumin Zhang,* Changsheng Zhang, Sizhan Liu, Jinmiao Tian, Shaohua  Wang Xiaomin Zhang, and Yongqiang Tu*, Nat. Commun., 2019, 10, 2507.

14. A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton. Lin Liu, Linsheng Lei, Zongsong Zhan, Sizhan Liu, Yuxiao Wang, YongqiangTu*, Fumin Zhang, Xiaoming Zhang, Aijun Ma, and Shaohua Wang*. Chem. Commun. 2019, 55, 3789.

15. Copper-catalyzed highly diastereoselective cross-dehydrogenative coupling between 8-hydroxyisochromanes and 1,3-dicarbonyl compounds. Zhen Zhang, Yongqiang Tu*, Xiaoming Zhang, Fumin Zhang, and Shaohua Wang. Org. Chem. Front. 2019, 6, 2275.

16. Organo-Cation Catalyzed Asymmetric Homo/Heterodialkylation of Bisoxindoles: Construction of Vicinal All-Carbon Quaternary Stereocenters and Total Synthesis of (−)-Chimonanthidine. Sikai Chen, Wenqiang Ma, Zhibo Yan, Fumin Zhang, Shaohua Wang, Yongqiang Tu*, Xiaoming Zhang, and Jinmiao Tian; J. Am. Chem. Soc. 2018, 140, 10099.

17. Electrophilic Trifluoromethylthiolation/Semipinacol Rearrangement: Preparation of β‑SCF3 Carbonyl Compounds with α‑Quaternary Carbon Center. Chaochao Xi, Zhimin Chen, Shuyu Zhang, and Yongqiang Tu*. Org. Lett. 2018, 20, 4227.

18. A catalytic allylic cation-induced intermolecular allylation-semipinacol rearrangement. Minghui Xu, Kunlong Dai, Yongqiang Tu*, Xiaoming Zhang, Fumin Zhang, and Shaohua Wang. Chem. Commun., 2018, 54, 7685.

19. Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Lin Liu, Hailong Cheng, Wenqiang Ma, Sihua Hou, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, and Shaohua Wang. Chem. Commun. 2018,  54, 196.

20. Recent Progress in the Isolation, Bioactivity, Biosynthesis, and Total Syntheses of Natural Spiroketals. Zhang F.-M., Zhang S.-Y.; Tu, Y.-Q.* Nat. Prod. Rep. 2018, 35, 75-104.

21. Recent Applications of the 1,2-Carbon Atom Migration Strategy in Complex Natural Product Total Synthesis. Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H. Chem. Soc. Rev., 2017, 46, 2272-2305.

22. Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B. Hou, S.-H.; Tu, Y.-Q.*; Wang, S.-H.; Xi, C.-C.; Zhang, F.-M.; Wang, S.-H.; Li, Y.-T.; Liu, L. Angew. Chem. Int. Ed. 2016, 55, 4456-4460.

23. Radical Aryl Migration Reactions and Synthetic Applications. Chen, Z.-M.; Zhang, X.-M.; Tu, Y.-Q.* Chem. Soc. Rev. 2015, 44, 5220-5245.

24. Tandem C-H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (-)-brussonol and (-)-przewalskine E. Jiao, Z.-W.; Tu, Y.-Q.*; Zhang, Q.; Liu, W.-X.; Zhang, S.-Y.; Wang, S.-H.; Zhang, F.-M.; Jiang, S. Nat. Commun. 2015, 6, 7332.

25. Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4] nonane-1, 6-diones. Yang, B.-M.; Cai, P.-J.; Tu, Y.-Q.*; Yu, Z.-X.; Chen, Z.-M.; Wang, S.-H.; Wang, S.-H.; Zhang, F.-M. J. Am. Chem. Soc. 2015, 137, 8344-8347.

26. Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Hou, S. H.; Tu, Y.-Q.*; Liu, L.; Zhang, F. M.; Wang, S. H.; Zhang, X. M. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.

27. Copper-Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols. Chen, Z. M.; Bai, W.; Wang, S. H.; Yang, B. M.; Tu, Y.-Q.*; Zhang, F. M. Angew. Chem. Int. Ed. 2013, 52, 9781-9785.

28. Total Synthesis of the Nominal Didemnaketal A. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D.; Hou, S. H.; Tu, Y.-Q.*; Kitching, W. Angew. Chem. Int. Ed. 2012, 51, 10846-10850. 

29. Organocatalytic Asymmetric Direct Csp3-H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers. Jiao, Z. W.; Zhang, S. Y.; He, C.; Tu, Y.-Q.*; Wang, S. H.; Zhang, F. M.; Zhang, Y. Q.; Li, H. Angew. Chem. Int. Ed. 2012, 51, 8811-8815.

30. Total Synthesis of (+/-)-Alopecuridine and Its Biomimetic Transformation into (+/-)-Sieboldine A. Zhang, X. M.; Tu, Y.-Q.*; Zhang, F. M.; Shao, H.; Meng, X. Angew. 21. Direct Sp3 alpha-C-H Activation and Functionalization of Alcohol and Ether. Zhang, S. Y.; Zhang, F. M.; Tu, Y.-Q.*Chem. Soc. Rev. 2011, 40, 1937-1949.

31. Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Wang, B. M.; Tu, Y.-Q.* Acc. Chem. Res. 2011, 44, 1207-1222.

32. Semipinacol Rearrangement in Natural Product Synthesis. Song, Z. L.; Fan, C. A.; Tu, Y.-Q.* Chem. Rev. 2011, 111, 7523-7556. 

33. Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral alpha-Oxa-Quaternary beta-Haloketones. Chen, Z. M.; Zhang, Q. W.; Chen, Z. H.; Li, H.; Tu, Y.-Q.*; Zhang, F. M.; Tian, J. M. J. Am. Chem. Soc. 2011, 133, 8818-8821.

34. Iron-Catalyzed C(sp(3))-C(sp(3)) Bond Formation through C(sp(3))-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes. Zhang, S. Y.; Tu, Y.-Q.*; Fan, C. A.; Zhang, F. M.; Shi, L. Angew. Chem. Int. Ed. 2009, 48, 8761-8764. 

35. Bronsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers. Zhang, Q. W.; Fan, C. A.; Zhang, H. J.; Tu, Y.-Q.*; Zhao, Y. M.; Gu, P.; Chen, Z. M. Angew. Chem. Int. Ed. 2009, 48, 8572-8575. 

36. Organocatalytic Asymmetric Vinylogous alpha-Ketol Rearrangement: Enantioselective Construction of Chiral All-Carbon Quaternary Stereocenters in Spirocyclic Diketones via Semipinacol-Type 1, 2-Carbon Migration. Zhang, E.; Fan, C. A.; Tu, Y.-Q.*; Zhang, F. M.; Song, Y. L. J. Am. Chem. Soc. 2009, 131, 14626-14627.

37. A Reaction for sp(3)-sp(3) C-C Bond Formation via Cooperation of Lewis Acid-Promoted/Rh-Catalyzed C-H Bond Activation. Shi, L.; Tu, Y.-Q.*; Wang, M.; Zhang, F. M.; Fan, C. A.; Zhao, Y. M.; Xia, W. J. J. Am. Chem. Soc. 2005, 127, 10836-10837. 

38. A Tandem Semipinacol Rearrangement/Alkylation of alpha-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1, 3-Diols. Hu, X. D.; Fan, C. A.; Zhang, F. M.; Tu, Y.-Q.* Angew. Chem. Int. Ed. 2004, 43, 1702-1705.

39. Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of alpha-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1, 3-Diol Units. Fan, C. A.; Wang, B. M.; Tu, Y.-Q.*; Song, Z. L. Angew. Chem. Int. Ed. 2001, 40, 3877-3880.

40. Stereoselective Reductive Rearrangement of alpha-Hydroxy Epoxides: A New Method for Synthesis of 1, 3-Diols. Tu, Y.-Q.*; Sun, L. D.; Wang, P. Z. J. Org. Chem. 1999, 64, 629-633.