兰州大学功能有机分子化学国家重点实验室页头logo

搜索
研究队伍
首页 > 研究队伍 > 院士

涂永强

201901181547794186557907.jpg

涂永强

中国科学院院士、博士、教授

电话:+86-931-8912293

传真:+86-931-8912582

邮箱:tuyq@lzu.edu.cn

·教育背景、工作经历

1996-至今       兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2004-2005      德国比勒费尔德大学,访问教授

1992-1995      澳大利亚昆士兰大学(合作导师: W. Kitching),博士后

1989-1992      兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师,副教授

1986-1989      兰州大学,理学博士

1985-1986      四川大学华西药学院,助教

1982-1985      兰州大学,理学硕士

1978-1982      兰州大学,学士

·荣誉奖励

2016               国家自然科学二等奖(第一完成人)

2015               教育部自然科学一等奖(第一完成人)

2015               中国化学会 “维善合成成就奖”

2012              “全国优秀科技工作者”

2006               甘肃省 “自然科学一等奖”

2005               美国Lilly公司 “杰出科研成就奖”

2004               教育部 “长江学者特聘教授”

2002               甘肃省 “科技进步一等奖”

2001               国家自然科学基金委 “创新群体” (学术带头人,连续三期资助)

2000               香港求是科技基金会 “杰出青年学者奖”

2000               国家自然科学基金委 “杰出青年基金”资助

1996               国家 “百千万人才工程”

1993               中国化学会 “优秀青年化学奖”

·研究兴趣

具有重要生物活性的天然产物全合成

手性氮杂螺环配体(催化剂)的设计、合成及催化不对称反应研究

·代表成果

1. Development of bifunctional organocatalysts and application to asymmetric total synthesis of naucleofficine I and II. Yong-Hai  Yuan, Xue Han, Fu-Ping Zhu, Jin-Miao Tian, Fu-Min Zhang, Xiao-Min Zhang, Yong-Qiang Tu*; Shao-Hua Wang, and Xiang Guo, Nat. Commun., 2019, 10, 3394.

2. Copper‐Complex‐Catalyzed Asymmetric Aerobic Oxidative Cross‐Coupling of 2‐Naphthols: Enantioselective Synthesis of 3,3′‐Substituted C1‐Symmetric BINOLs. Jin-Miao Tian, Ai-Fang Wang, Ju-Song Yang, Xiao-Jin Zhao, Yong-Qiang Tu*, Shu-Yu Zhang, and Zhi-Min Chen. Angew. Chem. Int. Ed., 2019, 58, 11023.

3. Enantioselective synthesis of cis-hydrobenzofurans bearing all-carbon quaternary stereocenters and application to total synthesis of (‒)-morphine. Qing Zhang, Fu-Min Zhang,* Chang-Sheng Zhang, Si-Zhan Liu, Jin-Miao Tian, Shao-Hua  Wang Xiao-Min Zhang, and Yong-Qiang Tu*, Nat. Commun., 2019, 10, 2507.

4. A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1'-cyclopentane] skeleton. Lin Liu, Lin-Sheng Lei, Zong-Song Zhan, Si-Zhan Liu, Yu-Xiao Wang, Yong-QiangTu,* Fu-Min Zhang, Xiao-Ming Zhang, Ai-Jun Ma, Shao-Hua Wang*. Chem. Commun., 2019, 55, 3789.

5. Copper-catalyzed highly diastereoselective cross-dehydrogenative coupling between 8-hydroxyisochromanes and 1,3-dicarbonyl compounds. Zhen Zhang, Yong-Qiang Tu,* Xiao-Ming Zhang, Fu-Min Zhang, Shao-Hua Wang. Org. Chem. Front. 2019, 6, 2275.

6. Organo-Cation Catalyzed Asymmetric Homo/Heterodialkylation of Bisoxindoles: Construction of Vicinal All-Carbon Quaternary Stereocenters and Total Synthesis of (−)-Chimonanthidine. Si-Kai Chen, Wen-Qiang Ma, Zhi-Bo Yan, Fu-Min Zhang, Shao-Hua Wang, Yong-Qiang Tu*, Xiao-Ming Zhang, and Jin-Miao Tian; J. Am. Chem. Soc. 2018, 140, 10099.

7. Electrophilic Trifluoromethylthiolation/Semipinacol Rearrangement: Preparation of β‑SCF3 Carbonyl Compounds with α‑Quaternary Carbon Center. Chao-Chao Xi, Zhi-Min Chen, Shu-Yu Zhang, and Yong-Qiang Tu* Org. Lett. 2018, 20, 4227.

8. A catalytic allylic cation-induced intermolecular allylation-semipinacol rearrangement Ming-Hui Xu,a Kun-Long Dai,a Yong-Qiang Tu*, Xiao-Ming Zhang, Fu-Min Zhanga and Shao-Hua Wang. Chem. Commun., 2018, 54, 7685.

9. Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C–H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Lin Liu, Hai-Long Cheng, Wen-Qiang Ma, Si-Hua Hou, Yong-Qiang Tu, * Fu-Min Zhang, Xiao-Ming Zhang, and Shao-Hua Wang. Chem. Commun. 201854, 196.

10. Recent Progress in the Isolation, Bioactivity, Biosynthesis, and Total Syntheses of Natural Spiroketals. Zhang, F.-M.; Zhang, S.-Y.; Tu, Y.-Q.* Nat. Prod. Rep. 2018, 35, 75-104.

11. Recent Applications of the 1,2-Carbon Atom Migration Strategy in Complex Natural Product Total Synthesis. Zhang, X.-M.; Tu, Y.-Q.*; Zhang, F.-M.; Chen, Z.-H.; Wang, S.-H. Chem. Soc. Rev., 2017, 46, 2272-2305.

12. Total Syntheses of the Tetracyclic Cyclopiane Diterpenes Conidiogenone, Conidiogenol, and Conidiogenone B. Hou, S.-H.; Tu, Y.-Q.*; Wang, S.-H.; Xi, C.-C.; Zhang, F.-M.; Wang, S.-H.; Li, Y.-T.; Liu, L. Angew. Chem. Int. Ed. 2016, 55, 4456-4460.

13.  Radical Aryl Migration Reactions and Synthetic Applications. Chen, Z.-M.; Zhang, X.-M.; Tu, Y.-Q.* Chem. Soc. Rev. 2015, 44, 5220-5245.

14. Tandem C-H oxidation/cyclization/rearrangement and its application to asymmetric syntheses of (-)-brussonol and (-)-przewalskine E. Jiao, Z.-W.; Tu, Y.-Q.*; Zhang, Q.; Liu, W.-X.; Zhang, S.-Y.; Wang, S.-H.; Zhang, F.-M.; Jiang, S. Nat. Commun. 2015, 6, 7332.

15. Organocatalytic Asymmetric Tandem Nazarov Cyclization/Semipinacol Rearrangement: Rapid Construction of Chiral Spiro[4.4] nonane-1, 6-diones. Yang, B.-M.; Cai, P.-J.; Tu, Y.-Q.*; Yu, Z.-X.; Chen, Z.-M.; Wang, S.-H.; Wang, S.-H.; Zhang, F.-M. J. Am. Chem. Soc. 2015, 137, 8344-8347.

16. Divergent and Efficient Syntheses of the Lycopodium Alkaloids (-)-Lycojaponicumin C, (-)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine. Hou, S. H.; Tu, Y.-Q.*; Liu, L.; Zhang, F. M.; Wang, S. H.; Zhang, X. M. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.

17. Copper-Catalyzed Tandem Trifluoromethylation/Semipinacol Rearrangement of Allylic Alcohols. Chen, Z. M.; Bai, W.; Wang, S. H.; Yang, B. M.; Tu, Y.-Q.*; Zhang, F. M. Angew. Chem. Int. Ed. 2013, 52, 9781-9785.

18. Total Synthesis of the Nominal Didemnaketal A. Zhang, F. M.; Peng, L.; Li, H.; Ma, A. J.; Peng, J. B.; Guo, J. J.; Yang, D.; Hou, S. H.; Tu, Y.-Q.*; Kitching, W. Angew. Chem. Int. Ed. 2012, 51, 10846-10850. 

19. Organocatalytic Asymmetric Direct Csp3-H Functionalization of Ethers: A Highly Efficient Approach to Chiral Spiroethers. Jiao, Z. W.; Zhang, S. Y.; He, C.; Tu, Y.-Q.*; Wang, S. H.; Zhang, F. M.; Zhang, Y. Q.; Li, H. Angew. Chem. Int. Ed. 2012, 51, 8811-8815.

20. Total Synthesis of (+/-)-Alopecuridine and Its Biomimetic Transformation into (+/-)-Sieboldine A. Zhang, X. M.; Tu, Y.-Q.*; Zhang, F. M.; Shao, H.; Meng, X. Angew. 21. Direct Sp3 alpha-C-H Activation and Functionalization of Alcohol and Ether. Zhang, S. Y.; Zhang, F. M.; Tu, Y.-Q.*Chem. Soc. Rev. 2011, 40, 1937-1949.

22. Stereoselective Construction of Quaternary Carbon Stereocenters via a Semipinacol Rearrangement Strategy. Wang, B. M.; Tu, Y.-Q.* Acc. Chem. Res. 2011, 44, 1207-1222.

23. Semipinacol Rearrangement in Natural Product Synthesis. Song, Z. L.; Fan, C. A.; Tu, Y.-Q.* Chem. Rev. 2011, 111, 7523-7556. 

24. Organocatalytic Asymmetric Halogenation/Semipinacol Rearrangement: Highly Efficient Synthesis of Chiral alpha-Oxa-Quaternary beta-Haloketones. Chen, Z. M.; Zhang, Q. W.; Chen, Z. H.; Li, H.; Tu, Y.-Q.*; Zhang, F. M.; Tian, J. M. J. Am. Chem. Soc. 2011, 133, 8818-8821.

25. Iron-Catalyzed C(sp(3))-C(sp(3)) Bond Formation through C(sp(3))-H Functionalization: A Cross-Coupling Reaction of Alcohols with Alkenes. Zhang, S. Y.; Tu, Y.-Q.*; Fan, C. A.; Zhang, F. M.; Shi, L. Angew. Chem. Int. Ed. 2009, 48, 8761-8764. 

26. Bronsted Acid Catalyzed Enantioselective Semipinacol Rearrangement for the Synthesis of Chiral Spiroethers. Zhang, Q. W.; Fan, C. A.; Zhang, H. J.; Tu, Y.-Q.*; Zhao, Y. M.; Gu, P.; Chen, Z. M. Angew. Chem. Int. Ed. 2009, 48, 8572-8575. 

27. Organocatalytic Asymmetric Vinylogous alpha-Ketol Rearrangement: Enantioselective Construction of Chiral All-Carbon Quaternary Stereocenters in Spirocyclic Diketones via Semipinacol-Type 1, 2-Carbon Migration. Zhang, E.; Fan, C. A.; Tu, Y.-Q.*; Zhang, F. M.; Song, Y. L. J. Am. Chem. Soc. 2009, 131, 14626-14627.

28. A Reaction for sp(3)-sp(3) C-C Bond Formation via Cooperation of Lewis Acid-Promoted/Rh-Catalyzed C-H Bond Activation. Shi, L.; Tu, Y.-Q.*; Wang, M.; Zhang, F. M.; Fan, C. A.; Zhao, Y. M.; Xia, W. J. J. Am. Chem. Soc. 2005, 127, 10836-10837. 

29. A Tandem Semipinacol Rearrangement/Alkylation of alpha-Epoxy Alcohols: An Efficient and Stereoselective Approach to Multifunctional 1, 3-Diols. Hu, X. D.; Fan, C. A.; Zhang, F. M.; Tu, Y.-Q.* Angew. Chem. Int. Ed. 2004, 43, 1702-1705.

30. Samarium-Catalyzed Tandem Semipinacol Rearrangement/Tishchenko Reaction of alpha-Hydroxy Epoxides: A Novel Approach to Highly Stereoselective Construction of 2-Quaternary 1, 3-Diol Units. Fan, C. A.; Wang, B. M.; Tu, Y.-Q.*; Song, Z. L. Angew. Chem. Int. Ed. 2001, 40, 3877-3880.

31. Stereoselective Reductive Rearrangement of alpha-Hydroxy Epoxides: A New Method for Synthesis of 1, 3-Diols. Tu, Y.-Q.*; Sun, L. D.; Wang, P. Z. J. Org. Chem. 1999, 64, 629-633.

免责声明 | 隐私保护 | 联系我们

Copyrights © All Rights Reserved 版权所有 兰州大学功能有机分子化学国家重点实验室 陇ICP备10000336号

事业单位