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杨彦龙

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杨彦龙

博士、副教授

电话:+86-17393106147

邮箱: ylyang@lzu.edu.cn

•教育背景、工作经历

2017-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授

2016-2017           中国科学院微生物研究所,  助理研究员

2013-2016           中国科学院昆明植物研究所,理学博士

2010-2013           中国科学院昆明植物研究所,理学硕士

2006-2010           四川大学,理学学士

•荣誉奖励

2017                    中国科学院优秀博士学位论文

2016                    中国科学院院长优秀奖

2016                    中国科学院优秀毕业生

•研究兴趣

基因组导向的高等真菌中天然产物的发现

高等真菌来源的活性天然产物的生物合成

药用天然产物的合成生物学

•代表成果 

1. Rapid discovery and functional characterization of diterpene synthases from basidiomycete fungi by genome mining. Xinlin Li#, Yuxing Xu#, Yuan Li, RuiZhang, Tianyuan Hu, Ping Su, Man Zhou, Ting Tang, Ying Zeng, Yan-Long Yang*, Wei Gao*. Fungal. Genet. Biol. 2019, 128, 36-42.

2. Clavipines A–C, antiproliferative meroterpenoids with a fused azepine skeleton from the basidiomycete Clitocybe clavipes. Zhaocui Sun, Nailiang Zhu, Man Zhou, Xiaowei Huo, Haifeng Wu, Yu Tian, Junshan Yang, Guoxu Ma*, Yan-Long Yang*, Xudong Xu*. Org. Chem. Front. 2019, 6, 3759-3765.

3. Identification and Characterization of a Membrane-Bound Sesterterpene Cyclase from Streptomyces somaliensis. Yanlong Yang, Yuting Zhang, Shasha Zhang, Qingwen Chen, Ke Ma, Li Bao, Yong Tao, Wenbing Yin, Guodong Wang, and Hongwei Liu, J. Nat. Prod. 2018, 81, 1089-1092.

4. Discovery and Characterization of a New Family of Diterpene Cyclases in Bacteria and Fungi. Yang, Y-L., Zhang, S-S., Ma, K., Xu, Y-X., Tao, Q-Q., Chen, Y-H., Chen, Juan., Guo, S-X., Ren, J-W., Wang, W-Z., Tao, Y., Yin, W-B., Liu, H-W. Angew. Chem. Int. Ed. 2017, 56, 4749-4752.

5. Recent Advance on Bioactive Compounds from the Edible and Medicinal Fungi in China. Yang, Y-L., Tao, Q-Q., Han, J-J., Bao, L., Liu, H-W. Medicinal Plants and Fungi: Recent Advances in Research and Development. 2017, pp 253-312.

6. A monooxygenase from Boreostereum vibrans catalyzes oxidative decarboxylation in a divergent vibralactone biosynthesis pathway. Yang, Y-L., Zhou, H., Du, G., Feng K-N., Feng, T., Fu, X-L., Liu, J-K.*, Zeng, Y.*  Angew. Chem. Int. Ed. 2016, 55, 5463-5466. 

7. Bioactive Sesquiterpenes from the Edible Mushroom Flammulina velutipes and Their Biosynthetic Pathway Confirmed by Genome Analysis and Chemical Evidence. Tao, Q-Q. #, Ma, K. #, Yang, Y-L. #, Wang, K., Chen, B-S., Huang, Y., Han, J-J., Bao, Li., Liu, X-B., Yang, Z-L., Yin, W-B., Liu, H-W. J. Org. Chem. 2016, 81, 9867-9877. (#co-first author) 

8. Elucidating the biosynthetic pathway for vibralactone, a novel pancreatic lipase inhibitor with a fused bicyclic β-lactone. Zhao, P-J.*, Yang, Y-L., Du, L-C., Liu, J-K., Zeng, Y.* Angew. Chem. Int. Ed.  2013, 52, 2298-2302. 

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