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戴 芳

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戴芳

博士、副教授

电话:+86-13679423578

邮箱:daifang@lzu.edu.cn

·教育背景、工作经历

2008-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,副教授

2007-2008           兰州大学化学化工学院、功能有机分子化学国家重点实验室,讲师

2004-2006           兰州大学化学化工学院、功能有机分子化学国家重点实验室,博士后

2004                    天津医科大学,博士学位

·研究兴趣

长期从事分子和细胞生物学相关研究工作,目前的研究兴趣集中于:(1)线粒体靶向的促氧化抗癌分子设计及其机制研究;(2)检测细胞氧化还原状态的荧光探针设计。

·代表成果

1. “Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores", Dai, F.;Yan, W.-J.;Du, Y.-T.;Bao, X.-Z.; Li, X.-Z.; Zhou, B.* Free Radic. Biol. Med. 2017, 108, 554-563.

2. “Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death", Tu, Z.-S.; Wang, Q.; Sun, D.-D.; Dai, F.*; Zhou, B.* Eur. J. Med. Chem. 2017, 134, 72-85.

3. “Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids", Dai, F.; Liu, G.-Y.; Li. Y.; Yan, W.-J.; Wang, Q.; Yang, J.; Lu, D.-L.; Ding, D.-J.; Lin, D.; Zhou, B.* Free Radic. Biol. Med. 2015, 85, 127-137. 

4. “Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog", Lin, D.; Dai, F.*; Sun, L.-D.; Zhou, B.* Mol. Nutr. Food Res. 2015, 59, 2395-2406.

5. “3, 4-dimethoxystilbene, a resveratrol derivative with anti-angiogenic effect, induces both macroautophagy and apoptosis in endothelial cells", Zhang, L.*; Jing, H.; Cui, L.; Li, H.; Zhou, B.; Zhou, G.; Dai, F.* J.Cell Biochem. 2013, 114, 697-707.

6. “Antioxidative Effects of Curcumin and its Analogues against the Free-radical-induced Peroxidation of Linoleic Acid in Micelles", Dai F.; Chen W.-F.; Zhou B.*; Yang L.; Liu Z.-L. Phytother. Res. 2009, 23, 1220-1228.

7. “Antioxidant synergism of green tea polyphenols with-tocopherol and L-ascorbic acid in SDS micelles", Dai F.; Chen W.-F.; Zhou B.* Biochimie 2008, 90, 1499-1505.


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