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李 亚

李 亚
李 亚
博士、副教授、硕士生导师
电话:
+86-931-8912592
邮箱:
liea@lzu.edu.cn

•教育背景、工作经历

2009-至今            兰州大学功能有机分子化学国家重点实验室,副教授

2005-2009           兰州大学功能有机分子化学国家重点实验室,讲师

2016-2017           美国德州理工大学,访问学者

2009-2010           美国密苏里大学,访问学者

2002-2005           中国科学院兰州化学物理研究所,博士

1999-2002           兰州大学化学化工学院,硕士

1995-1999           兰州大学化学化工学院,学士

•研究兴趣

(1)天然化合物分子结构多样性的研究;

(2)中草药中具有生物活性分子的发现;

(3)天然化合物分子中酶抑制剂的发现及其作用机理的研究。

•代表成果

1. Structurally Diverse Diterpenoids from the Roots of Euphorbia Fischeriana Steud. Ya Li, Xingzhi Jiao, Tinghong Lv, Meili Yang, and Kun Gao*, Fitoterapia 2022, 162, 105296.

2. New Acylglycosides from the Roots of Rheum palmatum L. Wei-Jiao Feng, Hong-Ying Yang, Yi-Lin He, Ya Li*, and Kun Gao*, Phytochem. Lett. 2022, 49, 83.

3. Isolation, Identification, and Activity Evaluation of Diterpenoid Alkaloids from Aconitum Sinomontanum. Ya Li*, Jun Zeng, Yu-hua Tian, Yanan Hou, Honghong Da, Jianguo Fang,  Kun Gao*, Phytochemistry 2021190, 112880.     

4. Chemical Structures of Lignans and Neolignans Isolated from Lauraceae. Ya Li*, Shuhan Xie, Jinchuan Ying, Wenjun Wei, and Kun Gao*. Molecules  201823, 3164.

5.Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma. Wenjun Wei, Qiuyan Song, Zaiqin Zheng, Xiaojun Yao, Ya Li*, and Kun Gao*. J. Nat. Prod201881, 2381-2391.

6. Antifungal Activities of Isoflavonoids from Uromyces striatus Infected Alfalfa. Ya Li, Guangda Li, Hitao Yu, Xingzhi Jiao, and Kun Gao*.Chem. Biodivers. 201815, e1800407.

7. Diterpenoids from Salvia miltiorrhiza and their immune-modulating activity. Wenjun Wei, Panpan Zhou, Changjun Lin, Weifeng Wang, Ya Li*, and  Kun Gao*. J. Agr. Food Chem. 201765, 59855993.

8. Aphapolins A and B: Two Nemoralisin Diterpenoids Isolated from Aphanamixis polystachya (Wall.)  Fuhu Fang, Wenjun Huang, Shuangyan Zhou, Zhengzhi Han, Manyu Li, Lifang Liu, Xiaozhen Wu, Xiaojun Yao, Ya Li*, and Chengshan Yuan*. Eur. J. Org. Chem. 2017, 4429-4433.

9. Spirochensilides A and B, two new rearranged triterpenoids from Abies chensiensis. Qianqian Zhao, Qiuyan Song, Kan Jiang, Guangda Li, Wenjun Wei, Ya Li*, and Kun Gao*. Org. Lett. 201517, 2760-2763. 

10. New lignans from the roots of Schisandra sphenanthera. Kan Jiang, Qiuyan Song, Shoujiao Peng, Qianqian Zhao, Guangda Li, Ya Li*, and Kun Gao*. Fitoterapia 2015103, 63-70. 

11. Inactivation of Protein Tyrosine Phosphatases by Dietary Isothiocyanates.  Sarah M.Lewis, Ya Li, Michael J. Catalano, Adrian R.Laciak, HarkewalSingh, Derrick R.Seiner, Thomas J.Reilly, John J.Tanner, and Kent S.Gates*. Bioorg. Med. Chem. Lett. 201525, 4549–4552.

12. Thiophene acetylenes and furanosesquiterpenes from Xanthopappus subacaulis and their antibacterial activities. Li Zhang, Chaojun Chen, Jia Chen, Qianqian Zhao, Ya Li*, and Kun Gao*. Phytochemistry 2014106, 134-140.

13. An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Li Zhang, Chunjiang Zhang, Dongbo Zhang, Juan Wen, Xiaowei Zhao, Ya Li*, and Kun Gao*. Tetrahedron Lett201455, 1815-1817.

14. Trinorsesquiterpenoids from Inula racemose. Yanyan Ma, Denggao Zhao, Ying Zhai, Ya Li*, and Kun Gao*. Phytochemistry Lett20136, 645-648.

 

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