王少华 博士、教授 电话：+86-931-8915686 邮箱：wangshh@lzu.edu.cn

· 教育背景、工作经历

2017-至今            兰州大学药学院、功能有机分子化学国家重点实验室，教授

2011-2017           兰州大学药学院，副教授

2006-2011           美国梅奥诊所 (导师: Yuan-Ping Pang)，博士后

2001-2006           兰州大学 (导师: 涂永强教授)，理学博士

1997-2001           兰州大学 (导师: 涂永强教授)，理学学士 

· 荣誉奖励

2018                  “长江学者奖励计划”青年学者

2017                    甘肃省普通高等学校青年教师成才奖；兰州大学青年五四奖章

2016                    国家自然科学二等奖（第四完成人）

2015                    教育部自然科学一等奖（第四完成人） 

· 研究兴趣

具有生物（药物）活性的小分子的设计与合成，以及天然药物分子全合成和相关合成方法学研究。

· 代表成果

1.Au(I)-Catalyzed Cyclization/Semipinacol Rearrangement Reaction of Allenes to Construct Quaternary Carbon-Containing Scaffolds. Tianlu Zheng, Ye Zhang, Along Gou, Fu Cheng, Sizhan Liu, Lan Yu*, Mingyue Cui, Xuetao Xu, Kun Zhang, and Shaohua Wang*. Org. Lett. 2020, 22, 7073-7077.

2.Direct Synthesis of 2-Substituted Benzonitriles via Alkylcyanation of Arynes with N,N-Disubstituted Aminomalononitriles. Wen Bao, Zhupeng Gao, Daping Jin, Caogen Xue, Huan Liang, Lingsheng Lei, Xuetao Xu, Kun Zhang, and Shaohua Wang*. Chem. Commun.  2020, 56, 7641-7644.

3.Al(OTf)₃-Catalyzed Tandem Coupling Reaction between N,N-Disubstituted Aminomalonitriles and Substituted Arenes: a Synthesis of 1-Cyano-bisindolylmethane Analogues. Linsheng Lei, Bowen Wang, Daping Jin, Zhupeng Gao, Huanliang, Shaohua Wang*, Xuetao Xu, Kun Zhang, and Xiaoyun Zhang*. Adv. Synth. Catal.  2020, 362, 2870-2875.

4.Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence. Ye Zhang, Tianlu Zheng, Fu Cheng, Kunlong Dai, Kun Zhang, Aijun Ma, Fumin Zhang, Xiaoming Zhang, Shaohua Wang*, and Yongqiang Tu*. Chem. Sci. 2020, 11, 3878-3884.

5.A catalytic asymmetric one-pot [3+2] cyclization/semipinacol rearrangement sequence: an efficient construction of a multi-substituted 3H-spiro[benzofuran-2,1′-cyclopentane] skeleton. Lin Liu, Linsheng Lei, Zongsong Zhan, Sizhan Liu, Yuxiao Wang, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang,  Aijun Ma, and Shaohua Wang *. Chem. Commun. 2019, 55, 3789-3792.

6.Improved synthesis of 8-oxabicyclo[3.2.1]octanes via tandem C-H oxidation/oxa-[3,3] Cope rearrangement/aldol cyclization. Lin Liu, Hailong Cheng, Wenqiang Ma, Sihua Hou, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, and  Shaohua Wang*. Chem. Commun. 2018, 54 , 196-199.

7.Copper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines. Wen Bao, Junqi Wang, Xuetao Xu, Banghong Zhang, Weiting Liu, Linsheng Lei,   Huan Liang, Kun Zhang, and Shaohua Wang*. Chem. Commun. 2018, 54, 8194-8197.

8.Construction of the [6,5,7,5] Tetracyclic Core of Calyciphylline A Type Alkaloids via a Tandem Semipinacol Rearrangement/Nicholas Reaction. Lin Liu, Hailong Cheng, Wenqiang Ma, Sihua Hou, Yongqiang Tu*, Fumin Zhang, Xiaoming Zhang, and  Shaohua Wang*.Org. Lett. 2017, 19, 4648-4651.

9.Zinc-promoted cyclization of tosylhydrazones and 2-(dimethylamino)malononitrile: an efficient strategy for the synthesis of substituted 1-tosyl-1H-pyrazoles. Banghong Zhang, Linsheng Lei, Sizhan Liu, Xueqing Mou, Weiting Liu, Shaohua Wang*, Jie Wang*, Wen Bao, and  Kun Zhang.  Chem. Commun. 2017, 53, 8545-8548.

10.Recent applications of the 1,2-carbon atom migration strategy in complex natural product total synthesis. Xiaoming Zhang , Yongqiang Tu*, Fumin Zhang, Zhihua Chen, and Shaohua Wang*. Chem. Soc. Rev. 2017, 46, 2272-2305.

11.Anti-inflammatory activity effect of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole on TPA-induced skin inflammation in mice. Xuetao Xu, Xueqing Mou, Qinmei Xi, Weiting Liu, Wenfeng Liu, Zhaojun Sheng, Xi Zheng, Kun Zhang, Zhiyun Du, Suqing Zhao, ShaohuaWang*. Bioorg. Med. Chem. Lett. 2016, 26, 5334-5339.

12.The Synthesis of Multisubstituted Pyrroles via a Copper-Catalyzed Tandem Three-Component Reaction. Xueqing Mou, Zhengliang Xu, Li Xu, Shaohua Wang*, Banghong Zhang, Di Zhang, Jie Wang, Weiting Liu, and Wen Bao. Org. Lett. 2016, 18, 4032-4035.

13.A Tin(IV) Chloride Promoted Tandem C-O Bond Cleavage/Nazarov Cyclization/Nucleophilic Addition Reaction of 1,1-Disubstituted Allylic Ethers toward the Synthesis of Multisubstituted Indenes. Chao Yang, Zhengliang Xu, Hui Shao, Xueqing Mou, Jie Wang, and Shaohua Wang*. Org. Lett. 2015, 17, 5288-5291.

14.An Au(i)-catalyzed rearrangement/cyclization cascade toward the synthesis of 2-substituted-1,4,5,6-tetrahydrocyclopenta[b]pyrrole. Xueqing Mou, Zhengliang Xu, Shaohua Wang*, Daoyong Zhu, Jie Wang, Wen Bao, Shijiang Zhou, Chao Yang, and Di Zhang. Chem. Commun. 2015, 51, 12064-12067.

15.Catalytic asymmetric semipinacol rearrangements. Shaohua Wang, Baosheng Li, and  Yongqiang Tu*. Chem. Commun. 2014, 50, 2393-2408.

16.Copper-catalyzed intermolecular azidocyanation of aryl alkenes. Li Xu, Xueqing Mou, Zhimin Chen,and Shaohua Wang*. Chem. Commun. 2014, 50, 10676-10679.

17.Divergent and Efficient Syntheses of the Lycopodium Alkaloids (−)-Lycojaponicumin C, (−)-8-Deoxyserratinine, (+)-Fawcettimine, and (+)-Fawcettidine.  Sihua Hou, Yongqiang Tu*, Lin Liu,  Fumin Zhang, Shaohua Wang*, and Xiaoming Zhang. Angew. Chem. Int. Ed. 2013, 52, 11373-11376.