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房建国

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房建国

博士、教授

电话:+86-15005282101

邮箱:fangjg@lzu.edu.cn

· 教育背景、工作经历

2009-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2007-2009           美国西北大学 (合作导师:Prof. Richard B. Silverman),博士后

2006-2007           美国Burnham Institute for Medical Research (合作导师:Prof. Stuart A. Lipton),博士后

2003-2005           瑞典Karolinska Institute (合作导师:Prof. Arne Holmgren),博士后

1998-2003           兰州大学 (导师: 刘中立教授),理学博士

1994-1998           兰州大学,理学学士

· 荣誉奖励

2017                    ACP Lectureship award (to Korea)

2016                   飞天学者特聘计划青年学者项目

2016                   'Rising Stars’in Research: Career advancement initiative for young investigators. By BBA – Molecular Basis of Disease

· 研究兴趣

展靶向生物氧化还原调控体系的小分子探针和药物

· 代表成果

1. Liangwei Zhang,* Shoujiao Peng, Jinyu Sun, Ruijuan Liu, Shudi Liu, and Jianguo Fang* A ratiometric fluorescent probe of methionine sulfoxide reductase with an improved response rate and emission wavelength. Chem Commun 2019, 55, 1502-1505.

2. Junmin Zhang, Baoxin Zhang, Xinming Li, Xiao Han, Ruijuan Liu, and Jianguo Fang* Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update. Med Res Rev 2019, 39, 5-39.

3. Juan Yao, Shoujiao Peng, Jianqiang Xu, and Jianguo Fang* Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway. BioFactors 2019, 45, 616-626.

4. Guodong Hu, Huiyi Jia, Lanning Zhao, Dong-Hyung Cho, and Jianguo Fang* Small molecule fluorescent probes of protein vicinal dithiols. Chin Chem Lett 2019, 30, 1704-1716.

5. Shoujiao Peng, Yanan Hou, Juan Yao, and Jianguo Fang* Activation of Nrf2 by costunolide provides neuroprotective effect in PC12 cells. Food Funct 2019, 10, 4143-4152.

6. Shoujiao Peng, Yanan Hou, Juan Yao, and Jianguo Fang* Neuroprotection of mangiferin against oxidative damage via arousing Nrf2 signaling pathway in PC12 cells. BioFactors 2019, 45, 381-392.

7. Yuxin Liu, Pengcheng Zhou, Honghong Da, Huiyi Jia, Feifei Bai, Guodong Hu, Baoxin Zhang,* Jianguo Fang* An Azo Coupling Strategy for Protein 3-Nitrotyrosine Derivatization. Chem Eur J 2019. 25, 11228-11232.

8. Tianyu Liu, Junmin Zhang,* Xiao Han, Jianqiang Xu, Yueting Wu, and Jianguo Fang* Promotion of HeLa cells apoptosis by cynaropicrin involving inhibition of thioredoxin reductase and induction of oxidative stress. Free Radic Biol Med 2019, 135, 216-226.

9. Ruijuan Liu, Danfeng Shi, Junmin Zhang, Xinming Li, Xiao Han, Xiaojun Yao,* and Jianguo Fang* Virtual screening-guided discovery of thioredoxin reductase inhibitors. Toxicol Appl Pharmacol 2019, 370, 106-116.

10. Xinming Li, Baoxin Zhang, Chaoxian Yan, Jin Li, Song Wang, Xiangxu Wei, Xiaoyan Jiang, Panpan Zhou, and Jianguo Fang* A fast and specific fluorescent probe for thioredoxin reductase that works via disulphide bond cleavage. Nat Commun 2019, 10, 2745.

11. Huiyi Jia, Guodong Hu, Danfeng Shi, Lu Gan, Hong Zhang, Xiaojun Yao, and Jianguo Fang* Fluorophore-Dependent Cleavage of Disulfide Bond Leading to a Highly Selective Fluorescent Probe of Thioredoxin. Anal Chem 2019, 91, 8524-8531.

12. Guodong Hu, Baoxin Zhang, Pengcheng Zhou, Yanan Hou, Huiyi Jia, Yuxin Liu, Lu Gan, Hong Zhang, Yiheng Mao, and Jianguo Fang* Depletion of protein thiols and the accumulation of oxidized thioredoxin in Parkinsonism disclosed by a red-emitting and environment-sensitive probe. J Mater Chem B 2019, 7, 2696-2702.

13. Yanan Hou, Xinming Li, Shoujiao Peng, Juan Yao, Feifei Bai, and Jianguo Fang* Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem 2019, 67, 8227-8234.

14. Xiao Han, Junmin Zhang,* Danfeng Shi, Yueting Wu, Ruijuan Liu, Tianyu Liu, Jianqiang Xu, Xiaojun Yao, and Jianguo Fang* Targeting Thioredoxin Reductase by Ibrutinib Promotes Apoptosis of SMMC-7721 Cells. J Pharmacol Exp Ther 2019, 369, 212-222.

15. Feifei Bai, Baoxin Zhang,* Yanan Hou, Juan Yao, Qianhe Xu, Jianqiang Xu, and Jianguo Fang* Xanthohumol Analogues as Potent Nrf2 Activators against Oxidative Stress Mediated Damages of PC12 Cells. ACS Chem Neurosci 2019, 10, 2956-2966.

16. Bao-Jun Wang, Rui-Juan Liu, Jianguo Fang, Ya-Wen Wang,* and Yu Peng* A water-soluble dual-site fluorescent probe for the rapid detection of cysteine with high sensitivity and specificity. Chem Commun 2019, 55, 11762-11765.

17. Wei Du, Run-Juan Liu, Jian-Guo Fang, Hong Gao, Ya-Wen Wang,* and Yu Peng* Two chemodosimeters for fluorescence recognition of biothiols in aqueous solution and their bioimaging application. Tetrahedron 2019, 75, 130477-130481

18. Chun-Xiao Jiang, Jie Li, Jun-Min Zhang, Xiao-Jie Jin, Bo Yu, Jian-Guo Fang, and Quan-Xiang Wu* Isolation, Identification, and Activity Evaluation of Chemical Constituents from Soil Fungus Fusarium avenaceum SF-1502 and Endophytic Fungus Fusarium proliferatum AF-04. J Agric Food Chem 2019, 67, 1839-1846.

19. Jun-Chen Wu, Yanan Hou, Qianhe Xu, Xiao-Jie Jin, Yaxiong Chen, Jianguo Fang, Burong Hu, and Quan-Xiang Wu* (+/-)-Alternamgin, a Pair of Enantiomeric Polyketides, from the Endophytic Fungi Alternaria sp. MG1. Org Lett 2019, 21, 1551-1554.

20. Redox-Dependent Copper Carrier Promotes Cellular Copper Uptake and Oxidative Stress-Mediated Apoptosis of Cancer Cells. Junmin Zhang, Dongzhu Duan, Jianqiang Xu, and Jianguo Fang*, ACS Appl Mater Inter 2018, 10, 33010-33021.

21. Small Molecules to Target the Selenoprotein Thioredoxin Reductase. Baoxin Zhang, Yuxin Liu, Xinming Li, Jianqiang Xu, and Jianguo Fang*, Chem Asian J 2018, 13, 3593-3600.

22. Highly selective fluorometric probes for detection of HClO in living cells. Jinyu Sun, Liangwei Zhang, Yuesong Hu, Jianguo Fang*, Sensor Actuat B-Chem 2018, 266, 447-454.

23. Xanthatin Promotes Apoptosis via Inhibiting Thioredoxin Reductase and Eliciting Oxidative Stress. Ruijuan Liu, Danfeng Shi, Junmin Zhang, Xinming Li, Xiao Han, Xiaojun Yao, and Jianguo Fang*, Mol Pharmaceut 2018, 15, 3285-3296.

24. Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells. Xinming Li, Yanan Hou, Xianke Meng, Chunpo Ge, Huilong Ma, Jin Li, and Jianguo Fang*, Angew Chem Int Ed Engl 2018, 57, 6141-6145.

25. A selective colorimetric and red-emitting fluorometric probe for sequential detection of Cu2+ and H2S. Yuesong Hu, Jie Kang, Panpan Zhou, Xiao Han, Jinyu Sun, Shudi Liu, Liangwei Zhang*, and Jianguo Fang*, Sensor Actuat B-Chem 2018, 255, 3155-3162.

26. Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2. Yanan Hou, SHoujiao Peng, Xinming Li, Juan Yao, Jianqiang Xu, and Jianguo Fang*, ACS Chem Neurosci 2018, 9, 3108-3116.

27.  Selective Activation of a Prodrug by Thioredoxin Reductase Providing a Strategy to Target Cancer Cells. Li, X.; Hou, Y.; Meng, X.; Ge, C.; Ma, H.; Li, J.; Fang, J.*Angew. Chem. Int. Ed.  2018, 57, 6141-6145.

28. A specific fluorescent probe reveals compromised activity of methionine sulfoxide reductases in Parkinson's disease. Zhang, L.; Peng, S.; Sun, J.; Yao, J.; Kang, J.; Hu, Y.; Fang, J.* Chem. Sci. 2017, 8, 2966-2972.

29. Targeting the Thioredoxin System for Cancer Therapy. Zhang, J.; Li, X.; Han, X.; Liu, R.; Fang, J.* Trends Pharmacol. Sci. 2017, 38, 794-808.

30. Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells. Duan, D.; Zhang, J.; Yao, J.; Liu, Y.; Fang, J.* J. Biol. Chem. 2016, 291, 10021-10031.

31. Naphthalimide Scaffold Provides Versatile Platform for Selective Thiol Sensing and Protein Labeling. Zhou, P.; Yao, J.; Hu, G.; Fang, J.* ACS Chem. Biol. 2016, 11, 1098-1105.

32.  Selective selenol fluorescent probes: design, synthesis, structural determinants, and biological applications. Zhang, B.; Ge, C.; Yao, J.; Liu, Y.; Xie, H.; Fang, J.* J. Am. Chem. Soc. 2015, 137, 757-769.

33. Synthesis of piperlongumine analogues and discovery of nuclear factor erythroid 2-related factor 2 (Nrf2) activators as potential neuroprotective agents. Peng, S.; Zhang, B.; Meng, X.; Yao, J.; Fang, J.*J. Med. Chem2015, 58, 5242-5255.

34. Synthesis of xanthohumol analogues and discovery of potent thioredoxin reductase inhibitor as potential anticancer agent. Zhang, B.; Duan, D.; Ge, C.; Yao, J.; Liu, Y.; Li, X.; Fang, J.* J. Med. Chem. 2015, 58, 1795-1805.

35. Highly selective off-on fluorescent probe for imaging thioredoxin reductase in living cells. Zhang, L.; Duan, D.; Liu, Y.; Ge, C.; Cui, X.; Sun, J.; Fang, J.* J. Am. Chem. Soc. 2014, 136, 226-233.

36. Dithiaarsanes induce oxidative stress-mediated apoptosis in HL-60 cells by selectively targeting thioredoxin reductase. Liu, Y.; Duan, D.; Yao, J.; Zhang, B.; Peng, S.; Ma, H.; Song, Y.; Fang, J.* J. Med. Chem. 2014, 57, 5203-5211.

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