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李 瀛

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李瀛

博士、教授

电话:+86-931-8912788  

邮箱: liying@lzu.edu.cn

·教育背景、工作经历

1997-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

1985-1997           兰州大学化学系、应用有机化学国家重点实验室,副教授

1985-1992           兰州大学化学系,讲师

1977-1985           兰州大学化学系,助教

1990-1993           兰州大学,理学博士

1985-1989           兰州大学,理学硕士

1974-1977           兰州大学,理学学士

·荣誉奖励

2009                    国家科技进步二等奖(第二完成人)

2008                    教育部科技进步一等奖(第二完成人)

2005                    享受国务院政府特殊津贴

2001                    国家教委科技进步二等奖(第三完成人)

1997                    宝钢教育奖学金优秀教师奖

1994                    国家教委科技进步二等奖(第二完成人)

·研究兴趣

具有重要生物活性天然产物的全合成;以新药开发为导向的应用研究

·代表成果

1.“Organohalogenite-Catalyzed Spiroketalization: Enantioselective Synthesis of Bisbenzannulated Spiroketal Cores.” Xue, J.*; Zhang, H.; Tian, T.; Yin, K.; Liu, D.; Jiang, X.*; Li, Y.*; Jin, X.; Yao, X. Adv. Synth. Catal. 2016, 358, 370-374.

2.“Alkynylation/Dearomatizative Cyclization to Construct Spiro 5.5 Undecanes.”Shao, J.; Li, L.*; Zhang, J.; Hu, J.; Xue, J.; Li, Y.* RSC Adv. 2016, 6, 31363-31366.

3.“Mg(ClO4)2-Promoted [4 + 3] Cycloaddition of Oxindole Derivatives with Conjugated Dienes: Concise Synthesis of Spirocycloheptane Oxindole Derivatives.”Liu, Y.; Sun, Z.; Li, S.; Xiang, K.; Zhang, Y.*; Li, Y.* RSC Adv. 2016, 6, 26954-26958.

4.“TMSI-Promoted Vinylogous Michael Addition of Siloxyfuran to 2-Substituted Chromones: A General Approach for the Total Synthesis of Chromanone Lactone Natural Products.”Liu, J.; Li, Z.; Tong, P.; Xie, Z.; Zhang, Y.*; Li, Y.* J. Org. Chem. 2015, 80, 1632-1643.

5.“Enantioselective Syntheses of Spiroketals via a Tandem Reaction of Cu(I)-Catalyzed Cycloetherification and Hydrogen-Bond-Induced [4+2] Cyclization.”Tian, T.; Li, L.; Xue, J.; Zhang, J.; Li, Y. J. Org. Chem. 2015, 80, 4189–4200.

6.“One Pot Hydroamination/ 4+3 Cycloaddition: Synthesis towards the Cyclohepta b Indole Core of Silicine and Ervatamine.”Zhang, J.; Shao, J.; Xue, J.*; Wang, Y.; Li, Y.* RSC Adv. 2014, 4, 63850-63854.

7.“Total Synthesis of Aphadilactones A–D.”Yin, J.-P.; Gu, M.; Li, Y.*; Nan, F.-J.* J. Org. Chem. 2014, 79, 6294-6301.

8.“Ivorenolide B, An Immunosuppressive 17-Membered Macrolide from Khaya ivorensis: Structural Determination and Total Synthesis.”Wang, Y.; Liu, Q.-F.; Xue, J.-J.; Zhou, Y.; Yu, H.-C.; Yang, S.-P.; Zhang, B.; Zuo, J.-P.; Li, Y.*; Yue, J.-M.* Org. Lett. 2014, 16, 2062-2065.

9.“Total Synthesis of (+/-)-delta-Rubromycin.”Wang, W.; Xue, J.*; Tian, T.; Zhang, J.; Wei, L.; Shao, J.; Xie, Z.; Li, Y.* Org. Lett. 2013, 15, 2402-2405.

10.“The First Asymmetric Total Synthesis of (+)-Coriandrone A and B.”Wang, W.; Xue, J.*; Tian, T.; Jiao, Y.; Li, Y.* Org. Biomol. Chem. 2013,11, 6686-6690.

11.“Regio- and Stereoselective 4+3 Cycloaddition Towards Fused 5,7,6-Tricyclic Skeletons.”Gong, W.; Liu, Y.; Zhang, J.; Jiao, Y.; Xue, J.*; Li, Y.* Chem. Asian J. 2013, 8, 546-551.

12.“A Novel, Facile Approach to Frondosin B and 5-epi-Liphagal via a New 4+3 -Cycloaddition.”Zhang, J.; Li, L.; Wang, Y.; Wang, W.; Xue, J.*; Li, Y.* Org. Lett. 2012, 14, 4528-4530.

13.“Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis: Structural Elucidation and Bioinspired Total Synthesis.”Zhang, B.; Wang, Y.; Yang, S.-P.; Zhou, Y.; Wu, W.-B.; Tang, W.; Zuo, J.-P.; Li, Y.*; Yue, J.-M.* J. Am. Chem. Soc. 2012, 134, 20605-20608.

14.“Construction of Aromatic 5, 5 Spiroketals via Hypoiodite-Catalyzed Etherification Combined in Relay Cascades.”Wei, W.; Wang, Y.; Yin, J.; Xue, J.*; Li, Y.* Org. Lett. 2012, 14, 1158-1161.

15.“New Fluoride-Promoted Hypoiodite-Catalytic Oxidative Cycloetherification to Aromatic Spiroketals.”Wei, W.; Li, L.; Lin, X.; Li, H.; Xue, J.*; Li, Y.* Org. Biomol. Chem. 2012, 10, 3494-3499.

16.“Synthesis of (+/-)-gamma-Rubromycin via a New Hypoiodite-Catalytic Oxidative Cycloetherification.”Wei, L.; Xue, J.*; Liu, H.; Wang, W.; Li, Y.* Org. Lett. 2012, 14, 5302-5305.

17.“Copper(I)-Catalyzed Hydroalkoxylation/Hydrogen-Bonding-Induced Asymmetric Hetero-Diels-Alder Cycloaddition Cascade: An Approach to Aromatic Spiroketals.” Li, X.; Xue, J.*; Huang, C.; Li, Y. Chem. Asian J. 2012, 7, 903-906.

18.“Construction of Two Vicinal Quaternary Carbons by Asymmetric Allylic Alkylation: Total Synthesis of Hyperolactone C and (-)-Biyouyanagin A.”Du, C.; Li, L.; Li, Y.; Xie, Z.* Angew. Chem., Int. Edit. 2009, 48 , 7853-7856.

19. ”An Efficient Synthesis of Highly Functionalized 5,6 Aromatic Spiroketals by Hetero-Diels-Alder Reaction.”Zhou, G.; Zhu, J.; Xie, Z.*; Li, Y.* Org. Lett. 2008, 10, 721-724.

20. “Total Synthesis of (+/-)-Quadrangularin A.”Li, W.; Li, H.; Li, Y.; Hou, Z.* Angew. Chem., Int. Edit. 2006, 45, 7609-7611.


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