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周 波

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周波

博士、教授

电话:+86-13639330926

邮箱: bozhou@lzu.edu.cn

•教育背景、工作经历

2004-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2000-2004           兰州大学生命科学院、功能有机分子化学国家重点实验室,博士后

1997-2000           兰州大学,理学博士

1994-1997           兰州大学,理学硕士

1989-1993           赣南师范大学,学士

•荣誉奖励

2014                    中国环境诱变剂学会活性氧生物学效应专业委员会常务委员

2013                    中国生物物理学会自由基生物学与自由基医学分会理事

2006                    入选教育部“新世纪优秀人才支持计划”

•研究兴趣

主要研究领域为:自由基化学和自由基生物学、化学生物学、生物有机和药物化学。主要研究兴趣集中于:基于癌细胞的氧化还原特征设计天然产物导向的促氧化抗癌分子。

•代表成果

1. A promising redox cycle-based strategy for designing a catechol-type diphenylbutadiene as a potent prooxidative anti-melanoma agent, Fang Dai#, Yu-Ting Du#, Ya-Long Zheng, and Bo Zhou*, Free Radic. Biol. Med. 2019, 130, 489-498.

2. Identification of catechol-type ddiphenylbutadiene as a tyrosinase-activated pro-oxidative chemosensitizer against melanoma A375 Cells via glutathione S-transferase inhibition, Yuan Ji, Fang Dai, Shuai Yan, Jing-Yang Shi, and Bo Zhou*, J. Agric. Food Chem. 2019, 67, 9060-9069.

3. Developing glutathione-activated catechol-type diphenylpolyenes as small molecule-based and mitochondria-targeted prooxidative anticancer theranostic prodrugs, Xia-Zhen Bao, Fang Dai, Qi Wang, Xiao-Ling Jin, and Bo Zhou*, Free Radic. Biol. Med. 2019, 134, 406-418.

4. Developing a julolidine-fluorescein-based hybrid as a highly sensitive fluorescent probe for sensing and bioimaging cysteine in living cells, Yuan Ji, Fang Dai, and Bo Zhou*, Talanta 2019, 197, 631-637.

5. Keto-enol-based modification on piperlongumine to generate a potent Cu(II) ionophore that triggers redox imbalance and death of HepG2 cells, Fang Dai, Cui-Hong Yuan, Yuan Ji, Yu-Ting Du, Xia-Zhen Bao, Ling-Xi Wu, Xiao-Ling Jin, and Bo Zhou*, Free Radic. Biol. Med. 2018, 120, 124-132.

6. A 1,8-naphthalimide-based turn-on fluorescent probe for imaging mitochondrial hydrogen peroxide in living cells, Fang Dai, Fang Jin, Ying Long, Xiao-Ling Jin, and Bo Zhou*, Free Radic. Res. 2018, 52, 1288-1295.

7. ROS-driven and preferential killing of HepG2 over L-02 cells by a short-term cooperation of Cu(II) and a catechol-type resveratrol analog, Fang Dai, Qi Wang, Gui-Juan Fan, Yu-Ting Du, and Bo Zhou*, Food Chem. 2018, 250, 213-220.

8. Targeting redox vulnerability of cancer cells by prooxidative intervention of a glutathione-activated Cu(II) pro-ionophore: Hitting three birds with one stone, Xia-Zhen Bao, Fang Dai, Xin-Rong Li, and Bo Zhou*, Free Radic. Biol. Med. 2018, 124, 342-352.

9. A Catechol-Type Resveratrol Analog Manifests Antiangiogenic Action by Constructing an Efficient Catalytic Redox Cycle with Intracellular Copper Ions and NQO1, Yi-Hua Wang, Fang Dai, and Bo Zhou*, Mol. Nutr. Food Res. 2018, 62, 1700969.

10. Applying an Electrophilicity-Based Strategy to Develop a Novel Nrf2 Activator Inspired from Dietary [6]-Shogaol, Yu-Ting Du, Ya-Long Zheng, Yuan Ji, Fang Dai*, Yong-Jing Hu, and Bo Zhou*, J. Agric. Food Chem. 2018, 66, 7983-7994.

11. Designing salicylaldehyde isonicotinoyl hydrazones as Cu(II) ionophores with tunable chelation and release of copper for hitting redox Achilles heel of cancer cells, Yuan Ji, Fang Dai, and Bo Zhou*, Free Radic. Biol. Med. 2018, 129, 215-226.

12. Designing dichlorobinaphthoquinone as a prooxidative anticancer agent based on hydrogen peroxide-responsive in situ production of hydroxyl radicals, Fang Dai, Wen-Jing Yan, Xing Fu, Ya-Long Zheng, Yu-Ting Du, Xia-Zhen Bao, Yan-Fei Kang, Xiao-Ling Jin, and Bo Zhou*, Eur. J. Med. Chem. 2018, 159, 317-323.

13. "Structural basis, chemical driving forces and biological implications of flavones as Cu(II) ionophores". Dai, F.; Yan, W.-J.; Du, Y.-T.; Bao, X.-Z.; Li, X.-Z.; Zhou, B.* Free Radic. Biol. Med. 2017, 108, 554-563.

14. "Design, synthesis, and evaluation of curcumin derivatives as Nrf2 activators and cytoprotectors against oxidative death". Tu, Z.-S.; Wang, Q.; Sun, D.-D.; Dai, F. *; Zhou, B.* Eur. J. Med. Chem. 2017, 134, 72-85.

15. "Developing piperlongumine-directed glutathione S-transferase inhibitors by an electrophilicity-based strategy". Wang, H.-B.; Jin, X.-L.; Zheng, J.-F.; Wang, F.; Dai, F.; Zhou, B.* Eur. J. Med. Chem. 2017, 126, 517-525.

16. "Designing piperlongumine-directed anticancer agents by an electrophilicity-based prooxidant strategy: A mechanistic investigation". Yan, W.-J.; Wang, Q.; Yuan, C.-H.; Wang, F.;  Ji, Y.; Dai, F.; Jin, X.-L.; Zhou, B.* Free Radic. Biol. Med. 2016, 97, 109-123.

17. "Toward an understanding of the role of a catechol moiety in cancer chemoprevention: The case of copper- and o-quinone-dependent Nrf2 activation by a catechol-type resveratrol analog". Lin, D.; Dai, F.*; Sun, L.-D.; Zhou, B.* Mol. Nutr. Food Res. 2015, 59, 2395-2406.

18. "Hexamethoxylated Monocarbonyl Analogues of Curcumin Cause G2/M Cell Cycle Arrest in NCI-H460 Cells via Michael Acceptor-Dependent Redox Intervention". Li, Y.; Zhang, L.-P.; Dai, F.; Yan, W.-J.; Wang, H.-B.; Tu, Z.-S.; Zhou, B.* J. Agric. Food Chem. 2015, 63, 7731-7742.

19. "A Curcumin Derivative That Inhibits Vinyl Carbamate-Induced Lung Carcinogenesis via Activation of the Nrf2 Protective Respons". Shen, T.; Jiang, T.; Long, M.; Chen, J.; Ren, D.-M.; Wong, P. K.; Chapman, E.*; Zhou, B.*; Zhang, D. D.* Antioxid. Redox Signal. 2015, 23, 651-664.

20. "Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids". Dai, F.; Liu, G.-Y.; Li. Y.; Yan, W.-J.; Wang, Q.; Yang, J.; Lu, D.-L.; Ding, D.-J.; Lin, D.; Zhou, B.* Free Radic. Biol. Med. 2015, 85, 127-137. 

21. "Development and mechanism investigation of a new piperlongumine derivative as a potent anti-inflammatory agent". Sun, L.-D.; Wang, F.; Dai, F.; Wang, Y.-H.; Lin, D.; Zhou, B.* Biochem. Pharmacol. 2015, 95, 156-169.

22. "Tailoring 3, 3' -Dihydroxyisorenieratene to Hydroxystilbene: Finding a Resveratrol Analogue with Increased Antiproliferation Activity and Cell Selectivity". Kang, Y. F.; Yan, W.-J.; Zhou, T.-W.; Dai, F.; Li, X.-Z.; Bao, X.-Z.; Du, Y.-T.; Yuan, C.-H.; Wang, H.-B.; Ren, X.-R.; Liu, Q.; Jin, X.-L.; Zhou, B.*; Zhang, J.* Chem. Eur. J. 2014, 20, 8904-8908.

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