董世辉 博士、教授、博士生导师 邮箱：dongsh@lzu.edu.cn 课题组主页：NaturalProductDong.cn

•教育背景、工作经历

2018-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授

2013-2018           伊利诺伊大学香槟分校 (导师: Satish K. Nair)，博士后

2011-2013           伊利诺伊大学芝加哥分校 (导师: Guido F Pauli/陈绍农)，博士后

2006-2011           中国科学院上海药物研究所 (导师: 岳建民) 天然药物化学，博士

2002-2006           武汉大学 药学院，药学，理学学士

•研究兴趣

•代表成果

1. Biosynthesis of the RiPP Trojan Horse Antibiotic Microcin C is Directed by the N-Formyl Peptide Substrate. Shihui Dong, Alexey Kulikovsky, Svetlana Dubiley, Konstantin Severinov*, and Satish K. Nair*. Chem. Sci. 2019,10, 2391-2395.

2. The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis. Wenjia Gu, Shihui Dong, Snigdha Sarkar, Satish K Nair*, Eric W Schmidt*. Method. Enzymol. 2018, 604, 113-163.

3. Enzymatic reconstitution of ribosomal peptide backbone thioamidation. Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K Nair*, and Douglas A Mitchell*. PNAS 2018, 12, 3030-3035.

4. Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.  Matthew C. O’Reilly, Shihui Dong, Francis M. Rossi, Kaleigh M. Karlen, Rohan S. Kumar, Satish K. Nair*, and Helen E. Blackwell*. Cell Chem. Biol. 2018, 20, 1128-1139.

5. Molecular basis for the substrate specificity of quorum signal synthases. Shihui Dong, Nicole Frane, Quin H. Christensen, E. Peter Greenberg, Rajesh Nagarajan, and Satish K. Nair*. PNAS 2017, 114, 9092-9097.

6. Prolyl isomerase Pin1 regulates the stability, transcriptional activity and oncogenic potential of Brd4.  XiangMing Hu, Shihui Dong, Jinjing Chen, Ruichuan Chen, Satish K Nair, Kun Ping Lu, and Linfeng Chen*. Oncogene 2017, 36 , 5177-5188.

7. The Pimeloyl-CoA Synthetase BioW Defines a New Fold for Adenylate-Forming Enzymes. Paola Estrada, Miglena Manandhar, Shihui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E. Cronan, and Satish K. Nair*. Nat. Chem. Biol. 2017, 13, 668-674.

8. The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold. Shihui Dong, Weixin Tang, Tiit Lukk, Satish K Nair, and Wilfred A van der Donk. eLife 2015, 4 , e07607.

9. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Weixin Tang, Shihui Dong, Lindsay M. Repka, Chang He, Satish K Nair*, and Wilfred A van der Donk*. Chem. Sci. 2015, 6, 6270-6279. 

10. Chemical constituents from Brucea Javanica. Shihui Dong, Jia Liu, Yingzi Ge, Lei Dong, Chenghui Xu, Jian Ding, Jianmin Yue*. Phytochemistry 2013, 85, 175-184. 

11. Lipophilized Steroid Saponins from Dioscorea villosa (Wild Yam). Shihui Dong, Geping Cai, Jose G. Napolitano, Dejan Nikolic, David C. Lankin, James B. McAlpine, Richard B. van Breemen, Djaja D. Soejarto, Guido F. Pauli, and Shaonong Chen*. Fitoterapia 2013, 91, 113-124. 

12. Triterpenoids from Melia Toosendan. Shihui Dong, Xiufeng He, Lei Dong, Yan Wu and Jianmin Yue*. Helv. Chim. Acta. 2012, 286-300. 

13. Diarylheptanoids from Dioscorea villosa (Wild Yam). Shihui Dong, Dejan Nikolic, Charlotte Simmler, Feng Qiu, Richard B. van Breemen, Djaja D. Soejarto, Guido F. Pauli, and Shaonong Chen*. J. Nat. Prod. 2012, 75, 2168-2177.

14. Constituents of Trigonostemon heterophyllus. Shihui Dong, Hongbing Liu, Chenghui Xu, Jian Ding, and Jianmin Yue*. J. Nat. Prod. 2011, 74, 2576-2581. 

15. Daphnane-Type Diterpenoids from Trigonostemon howii. Shihui Dong, Chuanrui Zhang, Chenghui Xu, Jian Ding, and Jianmin Yue*. J. Nat. Prod. 2011, 74, 1255-1261. 

16 Onoceranoid-Type Triterpenoids from Lansium domesticum. Shihui Dong, Chuanrui Zhang, Lei Dong, Yan Wu, and Jianmin Yue*. J. Nat. Prod. 2011, 74, 1042-1048. 

17. Mesendanins A-J, Limonoids from the Leaves and Twigs of Melia Toosendan. Shihui Dong, Chuanrui Zhang, Xiufeng He, Hongbing Liu, Yan Wu, and Jianmin Yue*. J. Nat. Prod. 2010, 73, 1344-1349.