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董世辉

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董世辉

博士、教授

邮箱:dongsh@lzu.edu.cn

课题组主页:NaturalProductDong.cn

教育背景、工作经历

2018-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2013-2018           伊利诺伊大学香槟分校 (导师: Satish K. Nair),博士后

2011-2013           伊利诺伊大学芝加哥分校 (导师: Guido F Pauli/陈绍农),博士后

2006-2011           中国科学院上海药物研究所 (导师: 岳建民) 天然药物化学,博士

2002-2006           武汉大学 药学院,药学,理学学士

•研究兴趣

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•代表成果

1.“Biosynthesis of the RiPP Trojan Horse Antibiotic Microcin C is Directed by the N-Formyl Peptide Substrate.” Shi-Hui Dong, Alexey Kulikovsky, Svetlana Dubiley, Konstantin Severinov*, and Satish K. Nair*. Chem. Sci. 2019 Just Accepted.

2.“The Biochemistry and Structural Biology of Cyanobactin Pathways: Enabling Combinatorial Biosynthesis.” Wenjia Gu, Shi-Hui Dong, Snigdha Sarkar, Satish K Nair*, Eric W Schmidt*. Methods in Enzymology, 2018, 604, 113-163.

3.“Enzymatic reconstitution of ribosomal peptide backbone thioamidation.” Nilkamal Mahanta, Andi Liu, Shihui Dong, Satish K Nair*, Douglas A Mitchell*. PNAS, 2018, 12, 3030-3035.

4.“Structural and Biochemical Studies of Non-native Agonists of the LasR Quorum-Sensing Receptor Reveal an L3 Loop "Out" Conformation for LasR.” Matthew C. O’Reilly,1 Shi-Hui Dong,1 Francis M. Rossi, Kaleigh M. Karlen, Rohan S. Kumar, Satish K. Nair*, and Helen E. Blackwell*. Cell Chem. Biol. 2018, 20, 1128-1139.

5.“Molecular basis for the substrate specificity of quorum signal synthases.”Shi-Hui Dong, Nicole Frane, Quin H. Christensen, E. Peter Greenberg, Rajesh Nagarajan, and Satish K. Nair*. PNAS, 2017, 114, 9092-9097.

6.“The enterococcal cytolysin synthetase has an unanticipated lipid kinase fold.” Shi-Hui Dong,1 Weixin Tang,1 Tiit Lukk, Satish K Nair, and Wilfred A van der Donk. eLife2015, DOI: 10.7554/eLife.07607.

7.“Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage.”Weixin Tang,1 Shi-Hui Dong,1 Lindsay M. Repka, Chang He, Satish K Nair*, and Wilfred A van der Donk*. Chem. Sci. 2015, 6, 6270-6279. 

8.“Prolyl isomerase Pin1 regulates the stability, transcriptional activity and oncogenic potential of Brd4.” XiangMing Hu, Shi-Hui Dong, Jinjing Chen, Ruichuan Chen, Satish K Nair, Kun Ping Lu, and Lin-Feng Chen*. Oncogene, 2017 doi:10.1038/onc.2017.137. 

9.“The Pimeloyl-CoA Synthetase BioW Defines a New Fold for Adenylate-Forming Enzymes.” Paola Estrada, Miglena Manandhar, Shi-Hui Dong, Jaigeeth Deveryshetty, Vinayak Agarwal, John E. Cronan, and Satish K. Nair*. Nat. Chem. Biol. 2017, 13, 668-674.

10.“Diarylheptanoids from Dioscorea villosa (Wild Yam).” Shi-Hui Dong, Dejan Nikolic, Charlotte Simmler, Feng Qiu, Richard B. van Breemen, Djaja D. Soejarto, Guido F. Pauli, and Shao-Nong Chen*. J. Nat. Prod. 2012, 75, 2168-2177.

11.“Constituents of Trigonostemon heterophyllus.” Shi-Hui Dong, Hong-Bing Liu, Cheng-Hui Xu, Jian Ding, and Jian-Min Yue*. J. Nat. Prod. 2011, 74, 2576-2581. 

12.“Daphnane-Type Diterpenoids from Trigonostemon howii.” Shi-Hui Dong, Chuan-Rui Zhang, Cheng-Hui Xu, Jian Ding, and Jian-Min Yue*. J. Nat. Prod. 2011, 74, 1255-1261. 

13.“Onoceranoid-Type Triterpenoids from Lansium domesticum.” Shi-Hui Dong, Chuan-Rui Zhang, Lei Dong, Yan Wu, and Jian-Min Yue*. J. Nat. Prod. 2011, 74, 1042-1048. 

14.“Mesendanins A–J, Limonoids from the Leaves and Twigs of Melia Toosendan.” Shi-Hui Dong, Chuan-Rui Zhang, Xiu-Feng He, Hong-Bing Liu, Yan Wu, and Jian-Min Yue*. J. Nat. Prod. 2010, 73, 1344-1349. 

15.“Chemical constituents from Brucea Javanica.” Shi-Hui Dong, Jia Liu, Ying-Zi Ge, Lei Dong, Cheng-Hui Xu, Jian Ding, Jian-Min Yue*. Phytochemistry, 2013, 85, 175-184. 

16.“Lipophilized Steroid Saponins from Dioscorea villosa (Wild Yam).” Shi-Hui Dong, Geping Cai, Jose G. Napolitano, Dejan Nikolic, David C. Lankin, James B. McAlpine, Richard B. van Breemen, Djaja D. Soejarto, Guido F. Pauli, and Shao-Nong Chen*. Fitoterapia, 2013, 91, 113-124. 

17.“Triterpenoids from Melia Toosendan.” Shi-Hui Dong, Xiu-Feng He, Lei Dong, Yan Wu and Jian-Min Yue*. Helv. Chim. Acta. 2012, 286-300. 


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