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杨尚东

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杨尚东

博士、教授、博士生导师

电话:+86-931-8912859

传真:+86-931-8912859

邮箱: yangshd@lzu.edu.cn

•教育背景、工作经历

2009-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2007-2009           芝加哥大学化学系 (导师: 何川),博士后

2006-2007           北京大学 (导师: 施章杰),博士后

2003-2006           兰州大学 (导师: 梁永民),理学博士

1997-2003           甘肃电力科学研究院工作,工程师

1993-1997           兰州大学,理学学士

•荣誉奖励

2015                    Thieme Chemistry Journal Award奖

2013                    中国百篇最具影响国际学术论文奖

2013                    国家自然科学二等奖(排名第四)

•研究兴趣

有机磷化学,不对称合成

•代表成果 

1. Palladium-Catalyzed Relay C-H Functionalization to Construct Novel Hybrid-Arylcyclophosphorus Ligand Precursors. Juan Wang, Peng-Bo Bai, and Shang-Dong Yang*, Chin. Chem. Lett. 2022, 33, 2397.

2. Lewis Acid-Catalyzed Pudovik Reaction-Phospha-Brook Rearrangement Sequence to Access Phosphoric Esters. Jin Yang, Dang-Wei Qian, and Shang-Dong Yang*, Beilstein J. Org. Chem. 2022, 18, 1188.

3. Temporary (PQO) directing group enabled carbazole ortho arylation via palladium catalysis, Zhi-Chao Qi, Qin-Xin Lou, Yuan Niu and Shang-Dong Yang*, Chem. Commun. 2021, 57, 2021-2024

4. Visible-light-facilitated P-center radical addition to CQX (X = C, N) bonds results in cyclizations. Chong Li, Juan Wang and Shangdong Yang*, Chem. Commun. 2021, 57, 7997-8002.

5. Heck Reaction Boosted Heterocycle Ring-Closing and Ring-Opening Rearrangement: A Strategy for the Synthesis of Indolyl-Type Ligands. Chong Li, Zhi-Chao Qi, Jing-Yu Li and Shangdong Yang*, J. Org. Chem. 2021, 86, 16977-16991.

6. The sequential C–H oxidation/asymmetric phosphonylation of primary alcohols to synthesize α-hydroxy phosphonates, Shifu Ying, Xiaoling Huang, Xinwei Guo and Shang-Dong Yang*, Green Synth. and Catal. 2021, 2, 315-319.

7. Enantioselective Cobalt-Catalyzed Reductive Cross-Coupling for theSynthesis of Axially Chiral Phosphine-Olefin Ligands, Xi Zhang, Juan Wang and Shang-Dong Yang*, ACS Catal.  2021, 11, 14008-14015.

8. New Staudinger Strategy Enabled N-Acyl Phosphinamidites Synthesis, Yuan-Yuan Zhu, Gang-Wei Wang, Jin Yang and Shang-Dong Yang*, CCS Chem., 2021, 3, 1702-1709.

9. Concise synthesis of N-phosphorylated amides through three-component reactions, Yuan-Yuan Zhu, Tao Zhang, Linlin Zhou and Shangdong Yang*, Green Chem. 2021, 23, 9417-9421.

10. Recent advances in the synthesis and applications of phosphoramides, Y Yuan-Yuan Zhu, Yuan Niu, Yan-Ning Niu and Shangdong Yang*, Org. Biomol. Chem. 2021, 19, 10296-10313.

11. Iridium(III)-Catalyzed C-H Functionalization of Triarylphosphine Oxides with Diazo Dicarbonyl Compounds: Synthesis of α-Aryl 1,3-Dicarbonyl Derivatives, Qin-Xin Lou, Jing-Yu Li and Shangdong Yang*, Synlett, 2021, 32, 1365-1370.

12. Recent advances in radical phosphorylation, Yuan Niu and Shangdong Yang*, Chem. Synth. 2021, 1, 12-14.

13. Ir(III)-Catalyzed C−H Functionalization of Triphenylphosphine Oxide toward 3‑Aryl Oxindoles. Qinxin Lou, Yuan Niu, Zhichao Qi, and Shangdong Yang*. J. Org. Chem. 202085, 14527-14536.

14. Copper-catalyzed arylation of polycyclic aromatic hydrocarbons by the P=O group. Yuan Niu, Zhichao Qi, Qinxin Lou, Pengbo Bai, and Shangdong Yang*. Chem. Commun202056, 14721-14724.

15. Diastereoselective Synthesis of P-Chirogenic and Atropisomeric 2,2'-Bisphosphino-1,1'-binaphthyls Enabled by Internal Phosphine Oxide Directing Groups. Chong Li, and Shangdong Yang*. Chinese J. Org. Chem202040, 2159-2160.

16. Bismuth(III)-Catalyzed Sequential Enamine-Imine Tautomerism/2-Aza-Cope Rearrangement of Stable β-Enaminophosphonates: One-Pot Synthesis of β-Aminophosphonates. Ming Jin, Shifu Yin, Shangdong Yang*. Org. Lett202022, 2811-2815.

17.Generation of a Key Synthon of Indole Alkaloid Synthesis by Palladium(II)-Catalyzed Indole 2-Methylenephosphorylation. Yuan Niu, Pengbo Bai, Qinxin Lou, and Shangdong Yang*. ChemCatChem  202012, 3644-3649.

18. Allylation of β-amino phosphonic acid precursor via palladium-NHC catalyzed allylic C-H activation. Wei Ren, Ming Jin, QianmingZuo, and Shangdong Yang*. Org. Chem. Front. 20207, 298-302.

19. Photo-induced phosphorus radical involved semipinacol rearrangement reaction: Highly synthesis of γ-oxo-phosphonates. Chunhai Wang, Xiaoling Huang, Xueting Liu, Suqian Gao, Bin Zhao, and Shangdong Yang*. Chinese  Chem. Lett. 202031, 677-680.

20. Pd-Catalyzed Heck-Type Reaction: Synthesizing Highly Diastereoselective and Multiple Aryl-Substituted P‑Ligands. Chong Li, Xiaoyue Qiang, Zhichao Qi, Bin Cao, Jingyu Li, and Shangdong Yang*. Org. Lett. 201921, 7138-7142.

21. Visible photocatalysis of novel oxime phosphonates: synthesis of β-aminophosphonates. Yonghong Li, Chunhai Wang, Suqian Gao, Fengming Qi, and Shangdong Yang*. Chem. Commun201955, 11888-11891.

22. Palladium-NHC-Catalyzed Allylic Alkylation of Pronucleophiles with Alkynes. Wei Ren, Qianming Zuo, Yanning Niu, and Shangdong Yang*. Org. Lett. 201921, 7956-7960.

23. Applications of transition metal catalyzed P-radical for synthesis of organophosphorus compounds. Wei Ren, Qiang Yang, and Shangdong Yang*. Pure Appl. Chem. 201991, 87-94.

24. NHCs-Catalyzed the Synthesis of Benzazole-Phoshpine Ligands under Air Condition. Wei Ren, Qianming Zuo, and Shangdong Yang*. Synlett  201930, 1719-1724. 

25. Visible-light-induced tandem phosphorylation cyclization of vinyl azides under mild conditions. Yonghong Li, Yuanyuan Zhu , and Shangdong Yang*. Org. Chem. Front. 20185, 822-826.

26. Rh(III)-Catalyzed Phosphine Oxide Migration Reactions: Selective Synthesis of 3-Phosphinoylindoles. Chunhai Wang, and Shangdong Yang*. Chem-Asian J. 201813, 2401-2404.

27. Autoxidation Photoredox Catalysis for the Synthesis of 2‑Phosphinoylindoles. Chunhai Wang, Yonghong Li, and Shangdong Yang*. Org. Lett. 2018, 20, 2382-2385.

28. Visible-Light-Catalyzed Phosphonation-Annulation: An Efficient Strategyto Synthesize β-Phosphonopyrrolidines and β-Phosphonolactones. Chong Li, Zhichao Qi, Qiang Yang, Xiaoyue Qiang, and Shangdong Yang*. Chinese J. Chem. 201836, 1052-1058.

29. Direct Allylic C(sp3)‑H Alkylation with 2‑Naphthols via Cooperative Palladium and Copper Catalysis: Construction of Cyclohexadienones with Quaternary Carbon Centers. Ming Jin, Wei Ren, Dangwei Qian, and Shangdong Yang*. Org. Lett. 201820, 7015-7019.

30. Photocatalyzed Intermolecular Aminodifluoromethylphosphonation of Alkenes: Facile Synthesis of a,a-Difluoro-g-aminophosphonates. Qiang Yang, Chong Li, Zhichao Qi, Xiaoyue Qiang, and Shangdong Yang*, Chem.-Eur. J. 201824, 14363-14367.

31. New Approaches for Biaryl-Based Phosphine Ligand Synthesis via P=O Directed C−H Functionalizations. Yanna Ma, Shixia Li, and Shangdong Yang*. Acc. Chem. Res. 201750, 1480-1492.

32. Highly Efficient and Divergent Construction of Chiral γ‑Phosphono-α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated C(sp3)−H Bonds. Qiang Yang, and Shangdong Yang*. ACS Catal. 20177, 5220-5224.

33. Direct Allylic C−H Bond Activation To Synthesize [Pd(η3‑cin)(IPr)Cl] Complex: Application in the Allylation of Oxindoles. Rongbin Hu, Chunhai Wang, Wei Ren, Zhong Liu, and Shangdong Yang*. ACS Catal. 20177, 7400-7404.

34. Diastereoselective Radical Oxidative C−H Aminations toward Chiral Atropoisomeric (P,N) Ligand Precursors. Yanna Ma, Mingxing Cheng, and Shangdong Yang*. Org. Lett. 201719, 600-603.

35. Palladium-Catalyzed Migratory Insertion of Isocyanides for Synthesis of C‑Phosphonoketenimines. Qiang Yang, Chong Li, Mingxing Cheng, and Shangdong Yang*. ACS Catal. 20166, 4715-4719.

36. Enantioselective synthesis of arylglycine derivatives by direct C–H oxidative cross-coupling. Xiaohong Wei, Gangwei Wang,  and Shangdong Yang*. Chem. Commun. 201551, 832-835.

37. A unique Copper-catalyzed Cross-coupling Reaction by Hydrogen (H2) Removal for the Stereoselective Synthesis of 3-phosphoindoles. Anxi Zhou, Liuliang Mao, Gangwei Wang, and Shangdong Yang*. Chem. Commun. 201450, 8529-8532.

38. Regio- and Stereoselective Allylic C−H Arylation with Electron-Deficient Arenes by 1, 1′-Bi-2-naphthol−Palladium Cooperation. Gangwei Wang, Anxi Zhou, Shixia Li, and Shangdong Yang*. Org. Lett. 201416, 3118-3121.

39.  Direct Annulations toward Phosphorylated Oxindoles by Silver-Catalyzed Carbon-phosphorus Functionalization of Alkenes. Yamin Li,  Meng Sun,  Hongli Wang,  Qiuping Tian, and Shangdong Yang*. Angew. Chem. Int. Ed. 201352, 3972-3976.

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