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高 坤

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高坤

博士、教授

电话:+86-13919481635

传真:+86-931-8912582

邮箱: npchem@lzu.edu.cn

•教育背景、工作经历

2002-至今            兰州大学化学化工学院、功能有机分子化学国家重点实验室,教授

2000-2002           法国巴黎第七大学 (合作导师: 范波涛),访问学者

1994-1997           兰州大学 (导师: 贾忠建),理学博士

1985-1989           兰州大学 (导师: 陈耀祖),理学硕士

1979-1983           兰州大学,理学学士

•荣誉奖励

2009                    甘肃省教学成果二等奖(排名第一)

2008                    宝钢优秀教师奖

2007                    兰州大学“师德标兵”以及“隆基教学名师”

2005                    教育部自然科学二等奖(排名第二)

•研究兴趣

主要从事天然产物化学研究,包括:中药和药用植物中天然产物新结构的发现;天然产物活性筛选、结构修饰及药物先导化合物的发现。应用现代分离、分析技术,已从中药、民族药及药用植物中挖掘出了上百种结构新颖的化合物,并在药理实验的指导下,发现数种有意义的生物活性物质及药物先导化合物。近年来在973项目的支持下,从事牧草次生代谢物的研究,取得了较重要的研究结果。

•代表成果

1. Alstonlarsines A−D, Four Rearranged Indole Alkaloids from Alstonia scholaris, Xu-Xin Zhu, Yao-Yue Fan, Lei Xu, Qun-Fang Liu, Jiang-Ping Wu, Jing-Ya Li, Jia Li, Kun Gao*, Jian-Min Yue*, Org. Lett. 2019, 21, 1471−1474.

2. Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica, Zai-Qin Zheng, Wen-Jun Wei, Junmin Zhang, Hang-Ying Li, Kai Xu, Jiayuan Xu, Bencan Tang, Ya Li*, Kun Gao*. J. Org. Chem. 2019, 84, 4473−4477.

3. Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum, Yi Long, Ting Tang, Li Ying Wang, Bin He, Kun Gao*, J. Nat. Prod. 2019, 82, 2229−2237.

4. Labdane-Type Diterpenoids from Leonurus japonicus and Their Plant-Growth Regulatory Activity, Hang Ying Li, Xing Peng, Xiaojie Jin, Wen-Jun Wei, Kai-Liang Ma, Ya Li, Jian-Jun Chen*, Kun Gao*. J. Nat. Prod. 2019, 82, 2568−2579.

5. Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from Abies chensiensis and Their Antibacterial Activity, Wen-Jun Wei, Qiu- Yan Song, Jing-Chuan Ying, Hang-Ying Li, Kai-Liang Ma, Yida Li, Ya Li*, Kun Gao*. J. Nat. Prod. 2019, 82, 2859−2869.

6. Thiol-inducible and Quick-response DNA Cross-linking Agent, Yuanzhen Xu, Hongbo Wei, Jianjun Chen,Kun Gao*, Bioorg.  Med. Chem. Lett. 2019, 29(2), 281-283.

7. Anti-inflammatory Evaluation and Structure-Activity Relationships of Diterpenoids Isolated from Euphorbia hylonoma, Wen-Jun Wei, Wei-Yan Qi, Xin-Mei Gao, Ke-Na Feng, Kai-Liang Ma, Hang-Ying Li, Ya Li,* Kun Gao*, Bioorg. Chem. 2019, 93, 103256.

8. Meroterpenoids with diverse ring systems and dioxolanone-type secondary metabolites from Phyllosticta capitalensis and their phytotoxic activity, Kai-Liang Ma, Wen-Jun Wei, Hang Ying Li, Qiu Yan Song, Shi-Hui Dong, Kun Gao*, Tetrahedron, 2019, 75, 4611−4619.

9. Phytotoxic Diterpenoids from Plants and Microorganisms, Wen-Jun Wei, Ya Li, Hang Ying Li, Kai-Liang Ma, Liu-Di Wang, Kun Gao*. Chem. Biodivers, 2019, 16(11), e1900398.

10. Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong, Wei-Yi Zhang, Jin-Xin Zhao, Li Sheng, Yao-Yue Fan, Jing-Ya Li, Kun Gao* Jian-Min Yue*,Org.Lett., 2018, 20, 4040−4043

11. Quorumolides A-C, Three Cembranoids from Euphorbia antiquorum,Wei-Yan Qi, Jin-Xin Zhao, Wen-Jun Wei, Kun Gao*, Jian-Min Yue*, J. Org. Chem., 2018, 83(2), 1041-1045.

12. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity, Wei Bai, Hong-Ying Yang, Xing-Zhi Jiao, Ke-Na Feng, Jian-Jun Chen*, and Kun Gao*,J. Nat. Prod., 2018, 81, 1777−1785

13. Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma, Wen-Jun Wei, Qiu-Yan Song, Zai-Qin Zheng, Xiaojun Yao, Ya Li*, Kun Gao*,J. Nat. Prod., 2018, 81, 2381−2391

14. Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta, Hang-Ying Li, Zai-Qin Zheng, Wen-Jun Wei, Jian-Jun Chen*, Kun Gao*,Tetrahedron Letters, 2018, 59, 3461–3466

15. Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea europaea L.), Jianteng Wei, Shuxian Wang, Dong Pei, Liangjing Qu, Ya Li, Jianjun Chen, Duolong Di, Kun Gao*,Natural Product Research, 2018, 32(16), 1967–1970

16. “Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria”, Zeng, J.; Zhang, D.-B.; Zhou, P.-P.; Zhang, Q.-L.; Zhao, L.; Chen, J.-J.*; Gao, K.* Org. Lett. 2017, 19, 3998–4001. 

17. “Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri”, Gobu, F.-R.; Chen, J.-J.; Zeng, J.; Wei, W.-J.; Wang, W.-F.; Lin, C.-J.; Gao, K.* J. Nat. Prod., 2017, 80, 2263-2268.

18. “Diterpenoids from Salvia miltiorrhiza and Their Immune-Modulating Activity”, Wei, W.-J.; Zhou, P.-P.; Lin, C.-J.; Wang, W.-F.; Li, Y.*; Gao, K.* J. Agric. Food Chem. 2017, 65, 5985−5993.

19. “Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa, A new targeted cytosolic thioredoxin reductase anticancer agent”, Yang, M.-L.; Zhang, J.-M.; Li, Y.; Han, X.; Gao, K.*; Fang, J.-G.* Arch. Biochem. Biophys. 2016, 607, 20-26. 

20. “Spirochensilides A and B, Two New Rearranged Triterpenoids from Abies chensiensis”, Zhao, Q.-Q.; Song, Q.-Y.; Jiang, K.; Li, G.-D.; Wei, W.-J.; Li, Y.; Gao, K.* Org. Lett., 2015, 17, 2760−2763.

21. “Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents”, Xu, Y.-Z.; Gu, X.-Y.; Peng, S.-J.; Fang, J.-G.; Zhang, Y.-M.; Huang, D.-J.; Chen, J.-J.; Gao, K.* Eur. J. Med. Chem. 2015, 94, 284-297.

22. “Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy”, Xu, Y.-Z.; Chen, J.-J.; Peng, S.-J.; Gu, X.-Y.; Sun, M.; Gao, K.*; Fang, J.-G. Org. Biomol. Chem., 2015, 13, 2634–2639. 

23. “Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity”, Qi, W.-Y.; Zhang, W.-Y.; Shen, Y.; Leng, Y.; Gao, K.*; Yue, J.-M.* J. Nat. Prod., 2014, 77, 1452-1458. 

24. “An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris”, Zhang, L.; Zhang, C.-J.; Zhang, D.-B.; Wen, J.; Zhao, X.-W.; Li, Y.; Gao, K.* Tetrahedron Letters, 2014, 55(10), 1815–1817. 

25. “Synthesis and Structure−Activity Relationships of N-Methyl-5, 6, 7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents”, Zhao, D.-G.; Chen, J.-J.; Du, Y.-R.; Ma, Y.-Y.; Chen, Y.-X.; Gao, K.*; Hu, B.-R.* J. Med. Chem., 2013, 56, 1467−1477.

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