•教育背景、工作经历

       2017/3-至今              兰州大学化学化工学院、功能有机分子化学国家重点实验室，教授

       2015/4-2017/2          The Scripps Research Institute (合作导师: Chi-Huey Wong)，研究助理

       2011/7-2015/3          UT Southwestern Medical Center (合作导师: Chuo Chen)，博士后

       2006/9-2011/6          兰州大学化学系(导师：厍学功)，有机化学博士

       2002/9-2006/7          兰州大学化学基地班，学士学位

•研究兴趣

研究方向：功能性糖全合成、方法学及新型靶点抗生素、免疫抑制剂药物研发以及相关通路研究。

•代表成果

1. Bioinspired Total Synthesis of Complex Nucleoside Antibiotics A201A, A201D and A201E. Wang, J.; Gao, J.; Guo, T.; Huo, X.; Zhang, W.; Liu, J.; Wang, X.*Angew. Chem. Int. Ed., 2023, 62, e202213810.

2. Total Synthesis of Complex Peptidyl Nucleoside Antibiotics: Asymmetric De Novo Syntheses of Miharamycin B and Its Biosynthetic Precursor. Huang, W.; Fan, S.; Mao, J.; Luo, S.; Tang, S.; Liu, J.*; Wang, X.* Angew. Chem. Int. Ed., 2022, 61, e202204907.

3. Enzyme-like C–H Oxidation of Glucosides Promoted by Visible Light. Wu, M.; Jiang, Q.; Tian, Q.; Guo, T.; Cai, F.; Tang, S.; Liu, J. *; Wang, X.*CCS Chem. 2022, 4, 3599–3608.

4. Generation of Fused Seven-Membered Polycyclic Systems via Ring Expansion and Application to the Total Synthesis of Sesquiterpenoids.Xing, Z.; Fang, B.; Luo, S.; Xie, X.; Wang, X.* Org. Lett. 2022, 24, 4034–4039.

5. Site-Selective C–H Alkylation of Myo-Inositol via Organic Photoredox Catalysis.Cao, H.; Guo, T.; Deng, X.; Huo, X.; Tang, S.; Liu, J.*; Wang, X.* Chem. Commun., 2022, 58, 9934-9937.

6.  Nonenzymatic Asparagine Motif Synthesis by Photoredox-Catalyzed Carbamoylation of Dehydroalanine. Guo, T.; Wang, H.; Wang, C.; Tang, S.; Liu, J. *; Wang, X.*J. Org. Chem. 2022, 87, 6852–6859.

7. Stereodivergent Synthesis of C-Glycosamino Acids via Pd/Cu Dual Catalysis. Yan, X.; Feng, F.; Zhou, L.; Chen, L.; Tang, S.; Liu, J.; Cai, F.; Wang, X. *.Science China Chemistry. 2021, 64, 552-557.

8. Palladium Catalyzed Reductive Heck Coupling and its Application in Total Synthesis of (-)-17-nor-Excelsinidine. Yuan LS.; Chen LR.; Yan XX.; Gao K*.; Wang XL*, RSC Adv. 2021, 11, 757.

9. Enantioselective α Functionalization of 1,3-Dithianes by Iridium-Catalyzed Allylic Substitution. Wang, P.P.；Jiang, Q.; Zhao, R.B.; Xie, X.G.;* Tang, S.C*.; Wang, X.L*, J. Org. Chem. 2020, 85, 12456−12467.

10. Dithiane-Induced [3+2] Cycloaddition Tactic for the Convergent Synthesis of Dihydropyrrole and Pyrrole Derivatives. Jia, H.B.; Min, D.; Guo, T.Y.; Wu, M.Z.; Wang, X.L*.; Liu, J*.; Tang SC*. J. Org. Chem. 2020, 85, 14847−14857.

11. Visible-light Promoted Dithioacetalization of Aldehydes with Thiols under Aerobic and Photocatalyst-free Conditions. Xing, Z.; Yang, M.; Sun, H.; Wang, Z.; Chen, P.; Liu, L.; Wang, X. * Xie, X.*.; She, X., Green Chem. 2018, 20, 5117.

12. Asymmetric Syntheses of Sceptrin and Massadine and Evidence for Biosynthetic Enantiodivergence. Ma, Z.; Wang, X.; Wang, X.; Gao, S.; Tan, X.; Ma, Y.; Lynch, V. M.; Chen, C. Science (Co-first auhor,Highlighted in C&EN News) 2014, 346, 219.

13. The Development of Highly Potent Inhibitors for Porcupine. Wang, X.; Moon, J.; Dodge, M.; Pan, X.; Zhang, L.; Hanson, J.; Tuladhar, R.; Ma, Z.; Shi, H.; Williams, N.; Amatruda, J.; Carroll, T.; Lum, L.; Chen, C. J. Med. Chem. 2013, 56, 2700–2704.