Bing Han Ph D., Professor  Tel：+86-931-8912500 E-mail： hanb@lzu.edu.cn Mailing Address: 222# South Tianshui Road, 730000, Lanzhou,                               Gansu, China

•Education and Experiences

2014- Present    College of Chemistry and Chemical Engineering, Lanzhou University, 

                            State Key Laboratory of Applied Organic Chemistry, Professor

2010-2014         College of Chemistry and Chemical Engineering, Lanzhou University, 

                            State Key Laboratory of Applied Organic Chemistry, Associate Professor

2008-2010         College of chemistry and Chemical Engineering, Lanzhou University，

                            State Key Laboratory of Applied Organic Chemistry, Assistant Professor

2006-2007         University of Huston (Advisor: Jay K. Kochi), Postdoc

2001-2006         Lanzhou University (Advisor: Zhong-Li Liu), Ph.D.

1996-2000         Northwestern Normal University, B.Sc.

•Honors and Awards 

2014                   The National Science Fund for Excellent Young Scholars

2013                   The MOE New Century Excellent Talents

•Research Topics

Radical reaction, Green synthetic methodology, Physical organic chemistry

1. Radical reaction: Develop new free radical reaction methodology research and promote free radical in the application of the organic synthesis, including the environmentally friendly initiation of free radicals, radical catalyzed reaction, and substituent-tuned electronic structure transformation of free radical and its mediated selective cyclization and addition reaction.  

2. Green synthetic methodology: Oxidation and oxygenation are fundamental reactions in organic synthesis. Dioxygen is not only an environmentally benign and abundant oxidant, but also an ideal oxygen source for the oxygenation of organic substrates. Due to its enormous importance in chemistry and biochemistry, we aim to develop novel autooxidation and catalytic oxidation (oxygenation) reactions for transformation of organic substrates. 

3. Physical organic chemistry: Stable organic radical synthesis, characterization and application, supramolecular assembly based on anion-π、cation-π、H-π and π-π interactions, study on charge-transfer and electron transfer complex.

•Publications

1. Regioselective Fluoroalkylphosphorylation of Unactivated Alkenes by Radical-Mediated Alkoxyphosphine Rearrangement. Dongtai Xie, Honglei Chen, Dian Wei, Bangyi Wei, Zhenghu Li, Jianwu Zhang, Wei Yu, and Bing Han*, Angew. Chem. Int. Ed. 2022, 61, e202203398.

2. Sequential Catalytic Annulations: Divergent Synthesis of Heterocycles through a Radical [1,4]-Oxygen Shift. Wen-Jun Han, Jian-Wu Zhang, Chao-Xian Yan, Jia-Wei Wang, Pan-Pan Zhou, and Bing Han*, Org. Lett. 2022, 24, 542.

3. Photocatalytic Anti-Markovnikov Radical Hydro- and Aminooxygenation of Unactivated Alkenes Tuned by Ketoxime Carbonates. Sheng-Qiang Lai^‡, Bang-Yi Wei^‡, Jia-Wei Wang, Wei Yu, and Bing Han*. Angew. Chem. Int. Ed. 2021, 60, 21997– 22003.

4. Radical 1,4/5-Amino Shift Enables Access to Fluoroalkyl-Containing Primary β(γ)-Aminoketones under Metal-Free Conditions, Dian Wei^‡, Tuming Liu^‡, Yiheng He, Bangyi Wei, Jiahao Pan, Jianwu Zhang, Ning Jiao, and Bing Han*. Angew. Chem. Int. Ed. 2021, 60, 26308–26313.

5. Electrochemically Tuned Oxidative [4+2] Annulation and Dioxygenation of Olefins with Hydroxamic Acids. Bangyi Wei^‡, Dongtai Xie^‡, Shengqiang Lai, Yu Jiang, Hong Fu, Dian Wei, and Bing Han*. Angew. Chem. Int. Ed. 2021, 60, 3182-3188.

6. Deconstructive Oxygenation of Unstrained Cycloalkanamines. Jianwu Zhang, Yuanrui Wang, Jiahao Pan, Yiheng He, Wei Yu, and Bing Han*. Angew. Chem. Int. Ed. 2020, 59, 3900-3904.

7. Decarboxylative Borylation of mCPBA-Activated Aliphatic Acids.Wei Dian, Liu Tuming, Zhou Bo, Han Bing*. Org. Lett. 2020, 22, 234-238.

8. 4-HO-TEMPO-Catalyzed Redox Annulation of Cyclopropanols with Oxime Acetates toward Pyridine Derivatives. Junlong Zhan, Mengwei Wu, Dian Wei, Bangyi Wei, Yu Jiang, Wei Yu, and Bing Han*. ACS Catal. 2019, 9, 4179-4188.

9. Silver-Catalyzed Site-Selective Ring-Opening and C–C Bond Functionalization of Cyclic Amines: Access to Distal Amino-Alkyl Side-Chain-Containing Quinones. Ruihua Liu, Yiheng He, Wei Yu, Bo Zhou, and Bing Han*. Org. Lett. 2019, 21, 4590−4594.

10. Theoretical study on the mechanism and chemoselectivity in gold(I)-catalyzed cycloisomerization of β,β-disubstituted ortho-(alkynyl)styrenes. Lin Zhou, Li Yang, Yanwen Zhang, Alexander M. Kirillov, Ran Fan*, and Bing Han*. Org. Chem. Front. 2019, 6, 2701-2712.

11. Cu-Catalyzed Radical Cascade Annulations of Alkyne-Tethered N-Alkoxyamides with Air: Facile Access to Isoxazolidine/1,2-Oxazinane-Fused Isoquinolin-1(2H)‑ones. Fei Chen, Shengqiang Lai, Feifei Zhu, Qiang Meng, Yu Jiang, Wei Yu, and Bing Han*. ACS Catal. 2018, 8, 8925-8931.

12. Cu-Catalyzed Aminoacyloxylation of Unactivated Alkenes of Unsaturated Hydrazones with Manifold Carboxylic Acids toward Ester-Functionalized Pyrazolines. Ruihua Liu, Ziqing Wang, Bangyi Wei, Jianwu Zhang, Bo Zhou, and Bing Han*. Org. Lett. 2018, 20, 4183-4186.

13. Cu-Catalyzed Oxyalkynylation and Aminoalkynylation of Unactivated Alkenes: Synthesis of Alkynyl-Featured Isoxazolines and Cyclic Nitrones. Wenjun Han, Yuanrui Wang, Jianwu Zhang, Fei Chen, Bo Zhou, and Bing Han*. Org. Lett. 2018, 20, 2960-2963.

14. Synthesis of Halomethyl Isoxazoles/Cyclic Nitrones via Cascade Sequence: 1,2-Halogen Radical Shift as a Key Link, Honglei Chen, Dian Wei, Jianwu Zhang, Chenglin Li, Wei Yu, and Bing Han*. Org. Lett. 2018, 20, 2906-2910.

15. Dioxygen Activation via Cu-Catalyzed Cascade Radical Reaction: An Approach to Isoxazoline/Cyclic Nitrone-Featured α-Ketols. Peng X.-X.^†, Wei D.^†, Han W.-J.^†, Chen F., Yu W., Han B.* ACS Catal. 2017, 7, 7830-7834.

16. Copper-Catalyzed Cascade Cyclization of 1,7-Enynes toward Trifluoromethyl- Substituted 1’H‑Spiro[azirine-2,4-quinolin]-2’(3H)-ones. Qiang Meng, Fei Chen, Wei Yu*, and Bing Han*. Org. Lett. 2017, 19, 5186-5186.

17. Iminoxyl Radical-Promoted Oxycyanation and Aminocyanation of Unactivated Alkenes: Synthesis of Cyano-Featured Isoxazolines and Cyclic Nitrones. Fei Chen, Feifei Zhu, Man Zhang, Ruihua Liu, Wei Yu, and Bing Han*. Org. Lett. 2017, 19, 3255-3258.

18. Cu-catalyzed [3+3] annulation for the synthesis of pyrimidines via β-C(sp³)−H functionalization of saturated ketones. Junlong Zhan, Mengwei Wu, Fei Chen, and Bing Han*. J. Org. Chem. 2016, 81,11994-12000.

19. Copper-Catalyzed Oxidative Oxyamination/Diamination of Internal Alkenes of Unsaturated Oximes with Simple Amines. Ruihua Liu, Dian Wei, Bing Han*, and Wei Yu*. ACS Catal. 2016, 6, 6525-6530.

20. Tert-Butyl Hydroperoxide (TBHP)-Initiated Vicinal Sulfonamination of Alkynes: A Radical Annulation toward 3-Sulfonylindoles. Fei Chen, Qiang Meng, ShangQing Han, and Bing Han*. Org. Lett. 2016, 18, 3330-3333.

21. TEMPO-Mediated Aza-Diels–Alder Reaction: Synthesis of Tetrahydropyridazines Using Ketohydrazones and Olefins. XiuLong Yang, XieXue Peng, Fei Chen, and Bing Han*. Org. Lett. 2016, 18, 2070-2073.

22. Synthesis of Isoxazoline/Cyclic Nitrone-Featured Methylenes Using Unsaturated Ketoximes: A Dual Role of TEMPO. Fei Chen, XiuLong Yang, ZhiWei Wu, and Bing Han*. J. Org. Chem. 2016, 81, 3042-3050.

23. Hydrazonyl Radical-Participated Tandem Reaction: A Strategy for the Synthesis of Pyrazoline-Functionalized Oxindoles. XiaoYong Duan, XiuLong Yang, PanPan Jia, Man Zhang, and Bing Han*. Org. Lett. 2015, 17, 6022-6025.

24. Transition from π Radicals to σ Radicals: Substituent-Tuned Cyclization of Hydrazonyl Radicals. Xiaoyong Duan, Nengneng Zhou, Ran Fang, Xiulong Yang, Wei Yu, and Bing Han*. Angew. Chem. Int. Ed. 2014, 53, 3158-3162.

25. Iminoxyl Radical-Promoted Dichotomous Cyclizations: Efficient Oxyoximation and Aminooximation of Alkenes. Xiexue Peng, Yunjing Deng, Xiulong Yang, Lin Zhang, Wei Yu, and Bing Han*. Org. Lett. 2014, 16, 4650-4653.

26. Synthesis of Isoxazoline-Functionalized Phenanthridines via Iminoxyl Radical- Participated Cascade Sequence. Xiulong Yang, Fei Chen, Nengneng Zhou, Wei Yu, and Bing Han*. Org. Lett. 2014, 16, 6476-6479.

27. Hydrazone Radical Promoted Vicinal Difunctionalization of Alkenes and Trifunctionalization of Allyls: Synthesis of Pyrazolines and Tetrahydropyridazines. Xiaoyong Duan, Xiulong Yang, Ran Fang, Xiexue Peng, Wei Yu, and Bing Han*. J. Org. Chem. 2013, 78, 10692-10704.

28. Oxime Radical Promoted Dioxygenation, Oxyamination and Diamination of Alkenes: Synthesis of Isoxazolines and Cyclic Nitrones. Bing Han, Xiulong Yang, Ran Fang, Wei Yu, Chao Wang, Xiaoyong Duan, and Shuai Liu. Angew. Chem. Int. Ed. 2012, 51, 8816-8820.