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Xuegong She

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 Xuegong She

Ph. D., Professor 

Tel:+86-0931-8912276

E-mail: shexg@lzu.edu.cn

Mailing Address: Office 304, State Key Laboratory of Applied Organic Chemistry, Department of Chemistry, Lanzhou University, Lanzhou, 730000, P. R. China.

Education and Experience

2002 - Present       College of chemistry and Chemical Engineering, Lanzhou University, 

                               State Key Laboratory of Applied Organic Chemistry, Professor

2001-2002             University of Oregon, Postdoc

1999-2001             Colorado State University (Advisor: Yian Shi), Postdoc

1996-1999             Lanzhou University, Ph. D.

1993-1996             Northwest University, M. Sc.

Honors and Rewards

2017                      Guohua Eminent Scholar Fellowship (leading talents)

2016                      ACP Lectureship Award (by Korea)

2015                      Gansu Provincial Natural Science Award (1st Prize)

2012                      Outstanding Expert in Gansu Province

2011                      National Science Fund for Distinguished Young Scholars

2010                      WuXi AppTec Life Science and Chemistry Research Award

2007                      Thieme Chemistry Journal Award

Research Topics

Total Synthesis of Bioactive Natural Products , Development of Efficient Green Organic Methodology

Publications

1. Collective Total Syntheses of Five Lycopodium Alkaloids. Feifei He, Shangbiao Feng, Yulong Zhao, Hongliang Shi, Xiaoguang Duan, Huilin Li, Xingang Xie, and Xuegong She*, Angew. Chem. Int. Ed. 2022, 61, e202205439.

2. Ten-Step Total Synthesis of (-)-Andranginine. Yulong Zhao, Jiaxin Li, Ruize Ma, Feifei He, Hongliang Shi, Xiaoguang Duan, Huilin Li, Xingang Xie, and Xuegong She*, Org. Lett. 2022, 24, 6880.

3. De Novo Diastereoselective Synthesis of 1-Hydroxyl Allogibberic Methyl Ester en Route to Diverse Bioactive Molecules. Jinyan Chen, Yunxia Yang, Chuanhua Wu, Liang Huo, Xingang Xie, Huilin Li*, and Xuegong She*, Org. Lett. 2022, 24, 6402.

4. Construction of the Skeleton of Lucidumone. Shiqiang Ma, Zhen Li, Pengfei Yu, Hongliang Shi, Hesi Yang, Jiuzhou Yi, Zheng Zhang, Xiaoguang Duan, Xingang Xie, and Xuegong She*, Org. Lett2022, 24, 5541.

5. Enantioselective Pictet-Spengler Condensation to Access the Total Synthesis of (+)-Tabertinggine. Dan Long, Gaoyuan Zhao, Zhiqiang Liu, Peiqi Chen, Shiqiang Ma, Xingang Xie, and Xuegong She*, Eur. J. Org. Chem. 2022, 2022, e202200088.

6. Total Synthesis of (+)-Tabertinggine. Dan Long, Zhiqiang Liu, Liang Huo, Hesi Yang, Jiuzhou Yi, Xingang Xie, and Xuegong She*, Tetrahedron 2022, 115, 132781.

7. Brønsted Acid and Lewis Acid Co-promoted Cascade Cyclization Reaction and Application to the Total Synthesis of Erysotramidine. Xiaolin Ju, Xiaojun Hu, Hongliang Shi, Shiqiang Ma, Feifei He, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Chem. Front. 2021, 8, 4839-4844.

8.  Rapid Construction of the Tricyclic Core of Annotinine Hydrate. Hongliang Shi, Jinwei Huang, Shiqiang Ma, Xiaolin Ju, Jinbo Duan, Xingang Xie, Xiaolei Wang, and Xuegong  She*, Tetrahedron 202182, 131934 .

9. Recent Advances in Total Synthesis of Diquinane-Containing Natural Products. Huilin Li*, Jing Zhang, and Xuegong She*. Chem.-Eur. J2021, https://doi.org/10.1002/cjoc.202000522

10. Total Synthesis of (-)-Pepluanol B: Conformational Control of the Eight-Membered Ring System. Jing Zhang, Meng Liu, Chuanhua Wu, Gaoyuan Zhao, Peiqi Chen, Lin Zhou, Xingang Xie, Ran Fang, Huilin Li*, and Xuegong She*. Angew. Chem. Int. Ed202059, 3966-3970.

11. Total Synthesis of (−)-Gardmultimine A. Peiqi Chen, Hesi Yang, Hao Zhang, Wei Chen, Zheng Zhang, Jing Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Lett202022, 2022–2025.

12. A Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation. Hao Zhang, Peiqi Chen, Hesi Yang, Shiqiang Ma, Zemin Wang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem2020, 85, 3954–3962.

13. Synthesis of 2,3-disubstituted indoles via a tandem reaction. Shiqiang Ma, Dan Long, Peiqi Chen, Hongliang Shi, Huilin Li, Ran Fang, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front20207, 2689-2695.

14. A copper-catalyzed radical coupling/fragmentation reaction: efficient access to β-oxophosphine oxides. Shangbiao Feng, Jinlai Li, Feifei He, Tao Li, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. Org. Chem. Front. 2019, 6, 946-951.

15. A concise approach to the tricyclic framework of longipinane- and ent-longipinane-type sesquiterpenoids. Min He, Jiuzhou Yi, Gaoyuan Zhao, Peiqi Chen, Dan Long, Xiaojun Hu, Huilin Li,Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Chem. Front. 20196, 383-387.

16. Total Synthesis of Aspidofractinine Alkaloid Paucidirinine. Weiwei Zhang, Shanhao Lin, Chenglong Du, Shangbiao Feng, Zaimin Liu, Jing Zhang, Xingang Xie, Xiaolei Wang, Huilin Li, and Xuegong She*. J. Org. Chem. 201984, 1111-1116.

17. Asymmetric Total Synthesis of (+)-Winchinine B. Zaimin Liu, Xiaolin Ju, Shiqiang Ma, Chenglong Du, Weiwei Zhang, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*. J. Org. Chem. 201984, 14994-15000.

18. Construction of the Tetracyclic Core of Calyciphylline B‑Type Daphniphyllum Alkaloids. Chenglong Du, Jing Fang, Jinyan Chen, Zaimin Liu, Huilin Li, Xiaolei Wang, Xingang Xie, and Xuegong She*, Org. Lett. 2019, 21, 8718−8721. 

19. Bioinspired total synthesis of (−)-gymnothelignan L. Peng Chen, Liang Huo, Huilin Li, Lin Liu, Ziyun Yuan, Hao Zhang, Shangbiao Feng, Xingang Xie, Xiaolei Wang,  and Xuegong She*. Org. Chem. Front. 20185, 1124.

20. Total synthesis of conosilane A via a site-selective C–H functionalization strategy. Ziyun Yuan, Xiaojun Hu, Hao Zhang, Lin Liu, Peng Chen, Min He, Xingang Xie, Xiaolei Wang, and Xuegong She*. Chem. Commun. 201854, 912-915.

21. Palladium-Promoted Neutral 1,4-Brook Rearrangement/Intra- molecular Allylic Cyclization Cascade Reaction: A Strategy for the Construction of Vinyl Cyclobutanols. Hao Zhang, Shiqiang Ma, Ziyun Yuan, Peng Chen, Xingang Xie, Xiaolei Wang, and Xuegong She*, Org. Lett. 201719, 3478-3481.

22. (3+2)-Annulation of p‑Quinamine and Aryne: A Strategy To Construct the Multisubstituted Hydrocarbazoles. Dengyu Xu, Yulong Zhao, Dengpeng Song, Zhuliang Zhong, Shangbiao Feng, Xingang Xie, Xiaolei Wang, and Xuegong She*. Org. Lett. 201719, 3600−3603.

23. Visible-light-mediated radical insertion/cyclization cascade reaction: synthesis of phenanthridines and isoquinolines from isocyanides. Shangbiao Feng, Tao Li, Chenglong Du, Peng Chen, Dengpeng Song, Jinlai Li, Xingang Xie, and Xuegong She*. Chem. Commun. 201753, 4585-4588.

24. Bioinspired Collective Syntheses of Iboga-Type Indole Alkaloids. Gaoyuan Zhao, Xingang Xie, Haiyu Sun, Ziyun Yuan, Zhuliang Zhong, Shouchu Tang, and Xuegong She*. Org. Lett. 201618, 2447-2450.

25. Short and Scalable Total Synthesis of Myrioneuron Alkaloids (±)-α,β-Myrifabral A and B. Dengpeng Song, Zhengshen Wang, Ruoming Mei, Weiwei Zhang, Donghui Ma, Dengyu Xu, Xingang Xie, and Xuegong She*. Org. Lett201618, 669-671.

26. Protecting-Group-Free Total Synthesis of (−)-Lycopodine via Phosphoric Acid Promoted Alkyne Aza-Prins Cyclization. Donghui Ma, Zhuliang Zhong, Zaimin Liu, Mingjie Zhang, Shiyan Xu, Dengyu Xu, Dengpeng Song, Xingang Xie, and Xuegong She*. Org. Lett. 201618, 4328−4331.

27. Gold-Catalyzed 1, 2-Acyloxy Migration/Intramolecular [3+2] 1, 3-Dipolar Cycloaddtion Cascade Reaction: An Efficient Strategy for Syntheses of Medium-Sized-Ring Ethers and Amines. Changgui Zhao, Xingang Xie, Shuangshuang Duan, Huilin Li, Ran Fang, and Xuegong She*. Angew. Chem. Int. Ed. 201453, 10789-10793.

28. N‑Heterocyclic Carbene-Catalyzed Formal [3+2] Annulation of Alkynyl Aldehydes with Nitrosobenzenes: A Highly Regioselective Umpolung Strategy. Runfeng Han, Jing Qi, Jixiang Gu, Donghui Ma, Xingang Xie, and Xuegong She*. ACS Catal. 20133, 2705-2709.

29. Pt-Catalyzed Tandem 1, 2-Acyloxy Migration/Intramolecular [3+2] Cycloaddition of Enynyl Esters. Huaiji Zheng, Jiyue Zheng, Binxun Yu, Qiang Chen, Xiaolei Wang, Yongping He, Zhen Yang, and Xuegong She*. J. Am. Chem. Soc2010132, 1788–1789.


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