Kun Gao Ph.D, Professor Tel：+86-13919481635 Fax：+86-931-8912582 E-mail： npchem@lzu.edu.cn Mailing Address: 222# South Tianshui Road, Lanzhou,                               Gansu, China

•Education and Experience

2002 - Present      State Key Laboratory of Applied Organic Chemistry, Professor 

2000-2002            Universite de Paris VII, Paris, France (Advisor: Botao Fan), Visiting scholar

1994-1997            Lanzhou University (Advisor: Zhong-Jian Jia), Ph.D.

1985-1989            Lanzhou University (Advisor: Yao-Zu Chen), M.Sc.

1979-1983            Lanzhou University, B.Sc.

•Honors and Awards

2009                    Second Prize for Teaching Achievements in Gansu Province (ranked first)

2008                    Baosteel Excellent Teacher Award of China

2007                    Model of Education Ethics of the University, Longji famous teacher

2005                    Second Prize of Natural Science of Ministry of Education (ranked second)

•Research Topics

Key Words: Natural Products, Chinese Medicines, Medicinal Plants, Drug-leading Compounds

Our group mainly focuses on the chemical research of natural products, including the discovery of new structures in traditional Chinese medicines and medicinal plants, the activity screening, structural modification and the discovery of drug-leading compounds. 

•Publications

1. Triterpenoids and Lignans from Schisandra Chinensis and Their Inhibition Activities of Cdc25A/B Phosphatases. Qian-Qian Zhao, Wen-Jun Wei, Ya Li, and Kun Gao*, Nat. Prod. Res. 2022, 36, 754.

2. Biochemical Reconstitution Reveals the Biosynthetic Timing and Substrate Specificity for Thioamitides. Jiang Xiong, Shangwen Luo*, Cheng-Xiao Qin, Jiao-Jiao Cui, Yu-Xia Ma, Meng-Xue Guo, Sha-Sha Zhang, Ya Li, Kun Gao, and Shi-Hui Dong*, Org. Lett. 2022, 24, 1518.

3. Jatrolignans C and D: New Neolignan Epimers from Jatropha curcas. Yi-Lin He, Pei-Zhi Huang, Hong-Ying Yang, Wei-Jiao Feng, Zhao-Cai Li, and Kun Gao*, Molecules 2022, 27, 3540.

4. Cardiac Glycosides from Digitalis lanata and Their Cytotoxic Activities. Hong-Ying Yang, Ya-Xiong Chen, Shangwen Luo, Yi-Lin He, Wei-Jiao Feng, Yue Sun, Jian-Jun Chen*, and Kun Gao*, RSC Adv. 2022, 12, 23240.

5. Cytotoxic Cardenolides from Calotropis Gigantea. Yi-Lin He, Hong-Ying Yang, Pei-Zhi Huang, Wei-Jiao Feng, and Kun Gao*, Phytochemistry, 2021, 192, 112951.

6. Cytochalasins from Xylaria sp. CFL5, an Endophytic Fungus of Cephalotaxus Fortunei. Kai‑Liang Ma, Shi‑Hui Dong, Hang‑Ying Li, Wen‑Jun Wei, Yong‑Qiang Tu, and Kun Gao*, Nat. Product. Bioprosp. 2021, 11, 87–98.

7. Inhibition of Thioredoxin Reductase by Santamarine Conferring Anticancer Effect in HeLa Cells. Junmin Zhang, Qianhe Xu, Hong-Ying Yang, Minghao Yang, Jianguo Fang and Kun Gao*, Front. Mol. Biosci. 2021, 8, 710676.

8. Construction of a Meroterpenoid-Like Compound Collection by Precursor-Assisted Biosynthesis. Panlong Ren, Xinyu Miao, Ting Tang, Yueting Wu, Jing Wang, Ying Zeng, Yun Li, Kun Gao*, and Yanlong Yang*. Org. Biomol. Chem. 2020, 18, 5850–5856.

9. Alstonlarsines A−D, Four Rearranged Indole Alkaloids from Alstonia scholaris. XuXin Zhu, Yaoyue Fan, Lei Xu, QunfFang Liu, Jiangping Wu, Jingya Li, Jia Li, Kun Gao*, and Jianmin Yue*. Org. Lett. 2019, 21, 1471−1474.

10. Heliaquanoids A-E, Five Sesquiterpenoid Dimers from Inula helianthus-aquatica. Zaiqin Zheng, Wenjun Wei, Junmin Zhang, Hangying Li, Kai Xu, Jiayuan Xu, Bencan Tang, Ya Li*, and Kun Gao*. J. Org. Chem. 2019, 84, 4473−4477.

11. Absolute Configuration and Biological Activities of Meroterpenoids from an Endophytic Fungus of Lycium barbarum. Yi Long, Ting Tang, Li Ying Wang, Bin He,and Kun Gao*. J. Nat. Prod. 2019, 82, 2229−2237.

12. Labdane-Type Diterpenoids from Leonurus japonicus and Their Plant-Growth Regulatory Activity. Hang Ying Li, Xing Peng, Xiaojie Jin, WenJun Wei, KaiLiang Ma, Ya Li, Jianjun Chen*, and Kun Gao*. J. Nat. Prod. 2019, 82, 2568-2579.

13. Highly Oxygenated Triterpenoids and Rare Tetraterpenoids from Abies chensiensis and Their Antibacterial Activity. WenJun Wei, Qiuyan Song, Jingchuan Ying, Hangying Li, Kailiang Ma, Yida Li, Ya Li*, and Kun Gao*. J. Nat. Prod. 2019, 82, 2859−2869.

14. Thiol-inducible and Quick-response DNA Cross-linking Agent. Yuanzhen Xu, Hongbo Wei, Jianjun Chen,and Kun Gao*. Bioorg.  Med. Chem. Lett. 2019, 29, 281-283.

15. Anti-inflammatory Evaluation and Structure-Activity Relationships of Diterpenoids Isolated from Euphorbia hylonoma. Wenjun Wei, Weiyan Qi, Xinmei Gao, Kena Feng, Kailiang Ma, Hangying Li, Ya Li*, and Kun Gao*. Bioorg. Chem. 2019, 93, 103256.

16. Kense ring systems and dioxolanone-type secondary metabolites from Phyllosticta capitalensis and their phytotoxic activity. Kailiang Ma, Wenjun Wei, Hang Ying Li, Qiu Yan Song, Shihui Dong,and Kun Gao*. Tetrahedron  2019, 75, 4611-4619.

17. Phytotoxic Diterpenoids from Plants and Microorganisms. Wenjun Wei, Ya Li, Hang Ying Li, Kailiang Ma, Liudi Wang, Kun Gao*. Chem. Biodivers. 2019, 16, e1900398.

18. Mangelonoids A and B, Two Pairs of Macrocyclic Diterpenoid Enantiomers from Croton mangelong. Weiyi Zhang, Jinxin Zhao, Li Sheng, Yaoyue Fan, Jingya Li, Kun Gao*, and Jianmin Yue*. Org.Lett. 2018, 20, 4040−4043

19. Quorumolides A-C, Three Cembranoids from Euphorbia antiquorum. Weiyan Qi, Jinxin Zhao, WenjJun Wei, Kun Gao*, Jianmin Yue*. J. Org. Chem. 2018, 83, 1041-1045.

20. Structurally Diverse Highly Oxygenated Triterpenoids from the Roots of Ailanthus altissima and Their Cytotoxicity. Wei Bai, Hongying Yang, Xingzhi Jiao, Kena Feng, Jianjun Chen*, and Kun Gao*. J. Nat. Prod. 2018, 81, 1777−1785.

21. Phytotoxic ent-Isopimarane-Type Diterpenoids from Euphorbia hylonoma. Wenjun Wei, Qiuyan Song, Zaiqin Zheng, Xiaojun Yao, Ya Li*, Kun Gao*. J. Nat. Prod. 2018, 81, 2381-2391.

22. Ligusaginoids A–D, four eremophilane-type sesquiterpenoid dimers and trimers from Ligularia sagitta. Hangying Li, Zaiqin Zheng, Wenjun Wei, Jianjun Chen*, Kun Gao*.Tetrahedron Lett. 2018, 59, 3461–3466

23. Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea europaea L.). Jianteng Wei, Shuxian Wang, Dong Pei, Liangjing Qu, Ya Li, Jianjun Chen, Duolong Di, Kun Gao*. Nat. Prod. Res. 2018, 32, 1967-1970.

24. Rauvomines A and B, Two Monoterpenoid Indole Alkaloids from Rauvolfia vomitoria. Jun Zeng, Dongbo Zhang, Panpan Zhou, Qili Zhang, Lei Zhao, Jianjun Chen*, and Kun Gao*. Org. Lett. 2017, 19, 3998–4001. 

25. Isolation, Structure Elucidition, and Immunosuppressive Activity of Diterpenoids from Ligularia fischeri. Fekadu-Roge Gobu, Jianjun Chen*, Jun Zeng, Wenjun Wei, Weifeng Wang, Changjun Lin, and Kun Gao*. J. Nat. Prod. 2017, 80, 2263-2268.

26. Diterpenoids from Salvia miltiorrhiza and Their Immune-Modulating Activity. Wenjun Wei, Panpan Zhou, Changjun Lin, Weifeng Wang, Ya Li*, and Kun Gao*. J. Agr. Food Chem. 2017, 65, 5985−5993.

27. Bioassay-guided isolation of dehydrocostus lactone from Saussurea lappa, A new targeted cytosolic thioredoxin reductase anticancer agent. Meili Yang, Junmin Zhang, Ya Li, Xiao Han, Kun Gao*, and Jianguo Fang*. Arch. Biochem. Biophys. 2016, 607, 20-26. 

28. Spirochensilides A and B, Two New Rearranged Triterpenoids from Abies chensiensis. Qianqian Zhao, Qiuyan Song, Kan Jiang, Guangda Li, Wenjun Wei, Ya Li*, and Kun Gao*. Org. Lett. 2015, 17, 2760−2763.

29. Design, synthesis and biological evaluation of novel sesquiterpene mustards as potential anticancer agents. Yuanzhen Xua, XueyanGu, Shoujiao Peng, Jianguo Fang, Yingmei Zhang, Dejun Huang, Jianjun Chen*, and Kun Gao*. Eur. J. Med. Chem. 2015, 94, 284-297.

30. Synthesis and biological studies of the thiols-triggered anticancer prodrug for a more effective cancer therapy. Yuanzhen Xu, Jianjun Chen, Ya Li, Shoujiao Peng, Xueyan Gu, Meng Sun, Kun Gao*, and  Jianguo Fang*. Org. Biomol. Chem. 2015, 13, 2634–2639. 

31. Ingol-Type Diterpenes from Euphorbia antiquorum with Mouse 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Activity. Weiyan Qi, Weiyi Zhang, Yu Shen, Ying Leng, Kun Gao*, and Jianmin Yue*. J. Nat. Prod. 2014, 77, 1452-1458. 

32. An unusual indole alkaloid with anti-adenovirus and anti-HSV activities from Alstonia scholaris. Li Zhang, ChunjiangZhang, Dongbo Zhang, Juan Wen, Xiaowei Zhao, Ya Li*, and Kun Gao*.Tetrahedron Lett. 2014, 55, 1815–1817. 

33. Synthesis and Structure-Activity Relationships of N-Methyl-5, 6, 7-trimethoxylindoles as Novel Antimitotic and Vascular Disrupting Agents. Denggao Zhao, JianJun Chen, Yarong Du, Yanyan Ma, Yaxiong Chen, Kun Gao*, and Burong Hu*. J. Med. Chem. 2013, 56, 1467−1477.